ID   TAP26_BOVIN             Reviewed;         241 AA.
AC   A5PJN1; Q32KL6;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-JUL-2007, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Thyroid transcription factor 1-associated protein 26;
DE            Short=TTF-1-associated protein 26;
DE   AltName: Full=Coiled-coil domain-containing protein 59;
GN   Name=CCDC59; Synonyms=TAP26;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus, and Hereford; TISSUE=Hippocampus, and Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the transcription complexes of the pulmonary
CC       surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances
CC       homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with NKX2-1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the TAP26 family. {ECO:0000305}.
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DR   EMBL; BC110033; AAI10034.1; -; mRNA.
DR   EMBL; BC142178; AAI42179.1; -; mRNA.
DR   RefSeq; NP_001092860.1; NM_001099390.1.
DR   AlphaFoldDB; A5PJN1; -.
DR   STRING; 9913.ENSBTAP00000047439; -.
DR   PaxDb; A5PJN1; -.
DR   PRIDE; A5PJN1; -.
DR   Ensembl; ENSBTAT00000050784; ENSBTAP00000047439; ENSBTAG00000036282.
DR   GeneID; 615189; -.
DR   KEGG; bta:615189; -.
DR   CTD; 29080; -.
DR   VEuPathDB; HostDB:ENSBTAG00000036282; -.
DR   VGNC; VGNC:26903; CCDC59.
DR   eggNOG; KOG3777; Eukaryota.
DR   eggNOG; KOG4819; Eukaryota.
DR   GeneTree; ENSGT00390000006546; -.
DR   HOGENOM; CLU_101023_0_0_1; -.
DR   InParanoid; A5PJN1; -.
DR   OMA; PNLNVQM; -.
DR   OrthoDB; 1634203at2759; -.
DR   TreeFam; TF324429; -.
DR   Reactome; R-BTA-5683826; Surfactant metabolism.
DR   Proteomes; UP000009136; Chromosome 5.
DR   Bgee; ENSBTAG00000036282; Expressed in spermatid and 104 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR013730; Fyv7/TAP26.
DR   PANTHER; PTHR15657; PTHR15657; 1.
DR   Pfam; PF08524; rRNA_processing; 1.
DR   PRINTS; PR01854; BR22PROTEIN.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..241
FT                   /note="Thyroid transcription factor 1-associated protein
FT                   26"
FT                   /id="PRO_0000298940"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          107..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        149..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        163
FT                   /note="N -> K (in Ref. 1; AAI10034)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   241 AA;  28339 MW;  B5ED36EA5E1BC995 CRC64;
     MAPVWPAARG RTGGLGTRGR VSPVEFRNKN VKRKTWRPNH LQAFAGSVRE GQGFAFRRKL
     KIQQTYKKLL RREKKSQTPS ESPFTDWYPD HLKHLYLAEE ERLKKQLRKA DQPLSEEQVD
     QPLPEDQGSS DQALSEERCS IEQPQPAEPC SIRINSINIP KKNKKKTSNQ KAQEEYEQIQ
     AKRAAKKQEF ERRKQEREEA QRLYKKKKME VFKILSKKTK KGQPNLNLQM EYLLKKIQEN
     N