TAP26_HUMAN
ID TAP26_HUMAN Reviewed; 241 AA.
AC Q9P031; Q9H2V5; Q9NW62;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Thyroid transcription factor 1-associated protein 26;
DE Short=TTF-1-associated protein 26;
DE AltName: Full=Coiled-coil domain-containing protein 59;
DE AltName: Full=TTF-1-associated protein BR2;
GN Name=CCDC59; Synonyms=BR22, TAP26; ORFNames=HSPC128;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND INTERACTION WITH
RP NKX2-1.
RX PubMed=11152647; DOI=10.1165/ajrcmb.24.1.4050;
RA Yang Y.-S., Yang M.-C., Wang B., Weissler J.C.;
RT "BR22, a novel protein, interacts with thyroid transcription factor-1 and
RT activates the human surfactant protein B promoter.";
RL Am. J. Respir. Cell Mol. Biol. 24:30-37(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-160.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP FUNCTION.
RX PubMed=12882447; DOI=10.1183/09031936.03.00117702;
RA Yang M.-C., Wang B., Weissler J.C., Margraf L.R., Yang Y.-S.;
RT "BR22, a 26 kDa thyroid transcription factor-1 associated protein (TAP26),
RT is expressed in human lung cells.";
RL Eur. Respir. J. 22:28-34(2003).
RN [6]
RP FUNCTION.
RX PubMed=16630564; DOI=10.1016/j.bbrc.2006.03.158;
RA Yang M.-C., Guo Y., Liu C.-C., Weissler J.C., Yang Y.-S.;
RT "The TTF-1/TAP26 complex differentially modulates surfactant protein-B
RT (SFTPB) and -C (SFTPBC) promoters in lung cells.";
RL Biochem. Biophys. Res. Commun. 344:484-490(2006).
CC -!- FUNCTION: Component of the transcription complexes of the pulmonary
CC surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances
CC homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities.
CC {ECO:0000269|PubMed:12882447, ECO:0000269|PubMed:16630564}.
CC -!- SUBUNIT: Interacts with NKX2-1. {ECO:0000269|PubMed:11152647}.
CC -!- INTERACTION:
CC Q9P031; P43361: MAGEA8; NbExp=3; IntAct=EBI-1047110, EBI-10182930;
CC Q9P031; P43699: NKX2-1; NbExp=4; IntAct=EBI-1047110, EBI-1391923;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Ubiquitously expressed. In lung, expression is
CC restricted to the alveolar epithelial cells.
CC {ECO:0000269|PubMed:11152647}.
CC -!- SIMILARITY: Belongs to the TAP26 family. {ECO:0000305}.
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DR EMBL; AF213377; AAG43569.1; -; mRNA.
DR EMBL; AF161477; AAF29092.1; -; mRNA.
DR EMBL; BC020647; AAH20647.1; -; mRNA.
DR EMBL; AK001156; BAA91524.1; -; mRNA.
DR CCDS; CCDS9023.1; -.
DR RefSeq; NP_054886.2; NM_014167.4.
DR AlphaFoldDB; Q9P031; -.
DR SMR; Q9P031; -.
DR BioGRID; 118850; 120.
DR IntAct; Q9P031; 52.
DR MINT; Q9P031; -.
DR STRING; 9606.ENSP00000256151; -.
DR iPTMnet; Q9P031; -.
DR PhosphoSitePlus; Q9P031; -.
DR BioMuta; CCDC59; -.
DR DMDM; 156633647; -.
DR EPD; Q9P031; -.
DR jPOST; Q9P031; -.
DR MassIVE; Q9P031; -.
DR MaxQB; Q9P031; -.
DR PaxDb; Q9P031; -.
DR PeptideAtlas; Q9P031; -.
DR PRIDE; Q9P031; -.
DR ProteomicsDB; 83538; -.
DR Antibodypedia; 29834; 76 antibodies from 17 providers.
DR DNASU; 29080; -.
DR Ensembl; ENST00000256151.8; ENSP00000256151.7; ENSG00000133773.12.
DR GeneID; 29080; -.
DR KEGG; hsa:29080; -.
DR MANE-Select; ENST00000256151.8; ENSP00000256151.7; NM_014167.5; NP_054886.2.
DR UCSC; uc001szp.5; human.
DR CTD; 29080; -.
DR DisGeNET; 29080; -.
DR GeneCards; CCDC59; -.
DR HGNC; HGNC:25005; CCDC59.
DR HPA; ENSG00000133773; Low tissue specificity.
DR MIM; 619280; gene.
DR neXtProt; NX_Q9P031; -.
DR OpenTargets; ENSG00000133773; -.
DR PharmGKB; PA143485412; -.
DR VEuPathDB; HostDB:ENSG00000133773; -.
DR eggNOG; KOG3777; Eukaryota.
DR eggNOG; KOG4819; Eukaryota.
DR GeneTree; ENSGT00390000006546; -.
DR HOGENOM; CLU_101023_0_0_1; -.
DR InParanoid; Q9P031; -.
DR OMA; PNLNVQM; -.
DR OrthoDB; 1634203at2759; -.
DR PhylomeDB; Q9P031; -.
DR TreeFam; TF324429; -.
DR PathwayCommons; Q9P031; -.
DR Reactome; R-HSA-5683826; Surfactant metabolism.
DR SignaLink; Q9P031; -.
DR BioGRID-ORCS; 29080; 641 hits in 1049 CRISPR screens.
DR ChiTaRS; CCDC59; human.
DR GenomeRNAi; 29080; -.
DR Pharos; Q9P031; Tbio.
DR PRO; PR:Q9P031; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q9P031; protein.
DR Bgee; ENSG00000133773; Expressed in secondary oocyte and 201 other tissues.
DR ExpressionAtlas; Q9P031; baseline and differential.
DR Genevisible; Q9P031; HS.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR013730; Fyv7/TAP26.
DR PANTHER; PTHR15657; PTHR15657; 1.
DR Pfam; PF08524; rRNA_processing; 1.
DR PRINTS; PR01854; BR22PROTEIN.
PE 1: Evidence at protein level;
KW Nucleus; Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..241
FT /note="Thyroid transcription factor 1-associated protein
FT 26"
FT /id="PRO_0000298941"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 182..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 136
FT /note="E -> G (in Ref. 4; BAA91524)"
FT /evidence="ECO:0000305"
FT CONFLICT 160
FT /note="P -> S (in Ref. 2; AAF29092)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 241 AA; 28670 MW; A9012048D32A87AE CRC64;
MAPVRRSAKW RPGGIEARGE GVSTVGYRNK NVRQKTWRPN HPQAFVGSVR EGQGFAFRRK
LKIQQSYKKL LRKEKKAQTS LESQFTDRYP DNLKHLYLAE EERHRKQARK VDHPLSEQVH
QPLLEEQCSI DEPLFEDQCS FDQPQPEEQC IKTVNSFTIP KKNKKKTSNQ KAQEEYEQIQ
AKRAAKKQEF ERRKQEREEA QRQYKKKKME VFKILNKKTK KGQPNLNVQM EYLLQKIQEK
C
