TAP26_MOUSE
ID TAP26_MOUSE Reviewed; 240 AA.
AC Q8R2N0; Q8BZ86; Q9CR69; Q9CV91;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 2.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Thyroid transcription factor 1-associated protein 26;
DE Short=TTF-1-associated protein 26;
DE AltName: Full=Coiled-coil domain-containing protein 59;
GN Name=Ccdc59; Synonyms=D10Ertd718e, Tap26;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, Muellerian duct, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the transcription complexes of the pulmonary
CC surfactant-associated protein-B (SFTPB) and -C (SFTPC). Enhances
CC homeobox protein Nkx-2.1-activated SFTPB and SFTPC promoter activities
CC (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with NKX2-1. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8R2N0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R2N0-2; Sequence=VSP_027489, VSP_027490;
CC -!- SIMILARITY: Belongs to the TAP26 family. {ECO:0000305}.
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DR EMBL; AK009028; BAB26036.1; -; mRNA.
DR EMBL; AK012917; BAB28548.1; -; mRNA.
DR EMBL; AK019970; BAB31941.1; -; mRNA.
DR EMBL; AK036330; BAC29386.1; -; mRNA.
DR EMBL; AK135550; BAE22578.1; -; mRNA.
DR EMBL; BC027401; AAH27401.1; -; mRNA.
DR CCDS; CCDS24158.1; -. [Q8R2N0-1]
DR RefSeq; NP_079878.1; NM_025602.3. [Q8R2N0-1]
DR AlphaFoldDB; Q8R2N0; -.
DR BioGRID; 206751; 5.
DR STRING; 10090.ENSMUSP00000020049; -.
DR PhosphoSitePlus; Q8R2N0; -.
DR EPD; Q8R2N0; -.
DR MaxQB; Q8R2N0; -.
DR PaxDb; Q8R2N0; -.
DR PeptideAtlas; Q8R2N0; -.
DR PRIDE; Q8R2N0; -.
DR ProteomicsDB; 263125; -. [Q8R2N0-1]
DR ProteomicsDB; 263126; -. [Q8R2N0-2]
DR Antibodypedia; 29834; 76 antibodies from 17 providers.
DR Ensembl; ENSMUST00000020049; ENSMUSP00000020049; ENSMUSG00000019897. [Q8R2N0-1]
DR GeneID; 52713; -.
DR KEGG; mmu:52713; -.
DR UCSC; uc007gyp.1; mouse. [Q8R2N0-1]
DR CTD; 29080; -.
DR MGI; MGI:1289302; Ccdc59.
DR VEuPathDB; HostDB:ENSMUSG00000019897; -.
DR eggNOG; KOG3777; Eukaryota.
DR eggNOG; KOG4819; Eukaryota.
DR GeneTree; ENSGT00390000006546; -.
DR HOGENOM; CLU_101023_0_0_1; -.
DR InParanoid; Q8R2N0; -.
DR OMA; PNLNVQM; -.
DR OrthoDB; 1634203at2759; -.
DR PhylomeDB; Q8R2N0; -.
DR TreeFam; TF324429; -.
DR Reactome; R-MMU-5683826; Surfactant metabolism.
DR BioGRID-ORCS; 52713; 10 hits in 76 CRISPR screens.
DR PRO; PR:Q8R2N0; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q8R2N0; protein.
DR Bgee; ENSMUSG00000019897; Expressed in epithelium of small intestine and 250 other tissues.
DR Genevisible; Q8R2N0; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR InterPro; IPR013730; Fyv7/TAP26.
DR PANTHER; PTHR15657; PTHR15657; 1.
DR Pfam; PF08524; rRNA_processing; 1.
DR PRINTS; PR01854; BR22PROTEIN.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..240
FT /note="Thyroid transcription factor 1-associated protein
FT 26"
FT /id="PRO_0000298942"
FT REGION 104..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 104..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 134..162
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 154
FT /note="S -> R (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027489"
FT VAR_SEQ 155..240
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_027490"
FT CONFLICT 105
FT /note="R -> S (in Ref. 2; AAH27401)"
FT /evidence="ECO:0000305"
FT CONFLICT 118
FT /note="Missing (in Ref. 2; AAH27401)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 28034 MW; 17DCB43406E5A909 CRC64;
MAPSRPSSKW RTGGFAARGE GISQVRFGNQ NGKRRTWRPN PQQAFRGSVR KGQGFAFRRK
LKIQQNYKKL LWKVKEAPAS QESQFTDRYP EHLKHLYLAE EERLRKQQRK AGLALSEEQV
DRPLPEEEGS TEQTSSEEPP GGHQPQPEEL NTGSSVTFPK NKKKKTSNQK AQEEYERVQA
KRAAKKFEFE MRKQEREEAQ RLYKKKKMEA FKILSKKTKK GQPNLNLQME YLLQKIQENS
