ID   TAP46_NICBE             Reviewed;         403 AA.
AC   D2K8N5;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 19.
DE   RecName: Full=PP2A regulatory subunit TAP46 {ECO:0000303|PubMed:21216945};
DE            Short=NbTAP46 {ECO:0000303|PubMed:21216945};
GN   Name=TAP46 {ECO:0000312|EMBL:ACZ65511.1};
OS   Nicotiana benthamiana.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4100;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pai H.-S.;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DISRUPTION PHENOTYPE, INTERACTION WITH NPP4 AND NPP5, SUBCELLULAR LOCATION,
RP   AND FUNCTION.
RX   PubMed=21216945; DOI=10.1105/tpc.110.074005;
RA   Ahn C.S., Han J.-A., Lee H.-S., Lee S., Pai H.-S.;
RT   "The PP2A regulatory subunit Tap46, a component of the TOR signaling
RT   pathway, modulates growth and metabolism in plants.";
RL   Plant Cell 23:185-209(2011).
RN   [3]
RP   ADDENDUM.
RX   PubMed=21597327; DOI=10.4161/psb.6.7.15651;
RA   Ahn C.S., Lee H.S., Pai H.S.;
RT   "Molecular functions of the PP2A regulatory subunit Tap46 in plants.";
RL   Plant Signal. Behav. 6:1067-1068(2011).
CC   -!- FUNCTION: Involved in the regulation of the TOR signaling pathway.
CC       Seems to act as a regulator of PP2A catalytic activity.
CC       {ECO:0000269|PubMed:21216945}.
CC   -!- SUBUNIT: Interacts with NPP4 and NPP5, two catalytic subunits (subunit
CC       C) of PP2A.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:21216945}. Nucleus
CC       {ECO:0000269|PubMed:21216945}.
CC   -!- DISRUPTION PHENOTYPE: RNAi plants show severe growth retardation, the
CC       formation of spontaneous disease-like nectrotic lesions leading to
CC       premature cell death. The defective plants also display a strong
CC       reduction in protein synthesis, the induction of autophagy and nitrogen
CC       mobilization. {ECO:0000269|PubMed:21216945}.
CC   -!- SIMILARITY: Belongs to the IGBP1/TAP42 family. {ECO:0000305}.
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DR   EMBL; GU189242; ACZ65511.1; -; mRNA.
DR   AlphaFoldDB; D2K8N5; -.
DR   SMR; D2K8N5; -.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   GO; GO:0031929; P:TOR signaling; IMP:UniProtKB.
DR   Gene3D; 1.25.40.540; -; 1.
DR   InterPro; IPR038511; TAP42/TAP46-like_sf.
DR   InterPro; IPR007304; TAP46-like.
DR   PANTHER; PTHR10933; PTHR10933; 1.
DR   Pfam; PF04177; TAP42; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus.
FT   CHAIN           1..403
FT                   /note="PP2A regulatory subunit TAP46"
FT                   /id="PRO_0000440566"
FT   REGION          158..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  45535 MW;  7E6A4941A0385A1C CRC64;
     MGELSMQEMP LPALFEQGSK IHASAESSVD QDTVRKGCEI LRQCEEMIGK LGLFSVNETK
     EDISTANLKY ILVPYYLAEL TEKVADNDRI KVLKASQAKL KEFISFCETM ELVPEEEIET
     STQGGANSSV DRRAKKIARF KRQRAAESKL LEIKERKERR GRSTKAAALS SPVETEEDDV
     LDDDGEEERE AWLTTISLGL CKAFDLLEML KKEEEILSAV KEKQLQNGEK EFSQAILDER
     TKKVETWHRD AAARAHYTKP AAPITCATFA QDVIEGRAKV SQAHEHKHQP LIFGPASLVG
     RNPTTEREKI AAQVFQPHYR LPTMSIEEAG LTEMNMMNEW QERNVKLMEE ANSSWYKDAP
     KSRPGEDDEE DDDDAAQDKA RAWDDWKDDN PRGAGNKKLT PCG