ID   TAP46_ORYSJ             Reviewed;         418 AA.
AC   Q2QY04; A3CES3; Q84PC7;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=PP2A regulatory subunit TAP46 {ECO:0000303|PubMed:21216945};
GN   Name=TAP46 {ECO:0000303|PubMed:21216945};
GN   OrderedLocusNames=LOC_Os12g04290 {ECO:0000312|EMBL:ABA95766.1},
GN   Os12g0137500 {ECO:0000312|EMBL:BAF29128.1};
GN   ORFNames=OsJ_35163 {ECO:0000312|EMBL:EAZ19586.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12684538; DOI=10.1073/pnas.0737574100;
RA   Cooper B., Clarke J.D., Budworth P., Kreps J., Hutchison D., Park S.,
RA   Guimil S., Dunn M., Luginbuehl P., Ellero C., Goff S.A., Glazebrook J.;
RT   "A network of rice genes associated with stress response and seed
RT   development.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4945-4950(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16188032; DOI=10.1186/1741-7007-3-20;
RG   The rice chromosomes 11 and 12 sequencing consortia;
RT   "The sequence of rice chromosomes 11 and 12, rich in disease resistance
RT   genes and recent gene duplications.";
RL   BMC Biol. 3:20-20(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [5]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=15685292; DOI=10.1371/journal.pbio.0030038;
RA   Yu J., Wang J., Lin W., Li S., Li H., Zhou J., Ni P., Dong W., Hu S.,
RA   Zeng C., Zhang J., Zhang Y., Li R., Xu Z., Li S., Li X., Zheng H., Cong L.,
RA   Lin L., Yin J., Geng J., Li G., Shi J., Liu J., Lv H., Li J., Wang J.,
RA   Deng Y., Ran L., Shi X., Wang X., Wu Q., Li C., Ren X., Wang J., Wang X.,
RA   Li D., Liu D., Zhang X., Ji Z., Zhao W., Sun Y., Zhang Z., Bao J., Han Y.,
RA   Dong L., Ji J., Chen P., Wu S., Liu J., Xiao Y., Bu D., Tan J., Yang L.,
RA   Ye C., Zhang J., Xu J., Zhou Y., Yu Y., Zhang B., Zhuang S., Wei H.,
RA   Liu B., Lei M., Yu H., Li Y., Xu H., Wei S., He X., Fang L., Zhang Z.,
RA   Zhang Y., Huang X., Su Z., Tong W., Li J., Tong Z., Li S., Ye J., Wang L.,
RA   Fang L., Lei T., Chen C.-S., Chen H.-C., Xu Z., Li H., Huang H., Zhang F.,
RA   Xu H., Li N., Zhao C., Li S., Dong L., Huang Y., Li L., Xi Y., Qi Q.,
RA   Li W., Zhang B., Hu W., Zhang Y., Tian X., Jiao Y., Liang X., Jin J.,
RA   Gao L., Zheng W., Hao B., Liu S.-M., Wang W., Yuan L., Cao M.,
RA   McDermott J., Samudrala R., Wang J., Wong G.K.-S., Yang H.;
RT   "The genomes of Oryza sativa: a history of duplications.";
RL   PLoS Biol. 3:266-281(2005).
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=cv. Nipponbare; TISSUE=Pistil {ECO:0000312|EMBL:BAH01312.1};
RG   The rice full-length cDNA consortium;
RT   "Oryza sativa full length cDNA.";
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [8]
RP   IDENTIFICATION.
RX   PubMed=21216945; DOI=10.1105/tpc.110.074005;
RA   Ahn C.S., Han J.-A., Lee H.-S., Lee S., Pai H.-S.;
RT   "The PP2A regulatory subunit Tap46, a component of the TOR signaling
RT   pathway, modulates growth and metabolism in plants.";
RL   Plant Cell 23:185-209(2011).
RN   [9]
RP   ADDENDUM.
RX   PubMed=21597327; DOI=10.4161/psb.6.7.15651;
RA   Ahn C.S., Lee H.S., Pai H.S.;
RT   "Molecular functions of the PP2A regulatory subunit Tap46 in plants.";
RL   Plant Signal. Behav. 6:1067-1068(2011).
CC   -!- FUNCTION: Involved in the regulation of the TOR signaling pathway.
CC       Seems to act as a regulator of PP2A catalytic activity.
CC       {ECO:0000250|UniProtKB:D2K8N5}.
CC   -!- SIMILARITY: Belongs to the IGBP1/TAP42 family. {ECO:0000305}.
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DR   EMBL; AY224436; AAO72555.1; -; mRNA.
DR   EMBL; DP000011; ABA95766.1; -; Genomic_DNA.
DR   EMBL; AP008218; BAF29128.1; -; Genomic_DNA.
DR   EMBL; AP014968; BAT15809.1; -; Genomic_DNA.
DR   EMBL; CM000149; EAZ19586.1; -; Genomic_DNA.
DR   EMBL; AK242643; BAH01312.1; -; mRNA.
DR   RefSeq; XP_015620759.1; XM_015765273.1.
DR   AlphaFoldDB; Q2QY04; -.
DR   SMR; Q2QY04; -.
DR   IntAct; Q2QY04; 2.
DR   STRING; 4530.OS12T0137500-01; -.
DR   PaxDb; Q2QY04; -.
DR   PRIDE; Q2QY04; -.
DR   EnsemblPlants; Os12t0137500-01; Os12t0137500-01; Os12g0137500.
DR   GeneID; 4351453; -.
DR   Gramene; Os12t0137500-01; Os12t0137500-01; Os12g0137500.
DR   KEGG; osa:4351453; -.
DR   eggNOG; KOG2830; Eukaryota.
DR   HOGENOM; CLU_041824_0_0_1; -.
DR   InParanoid; Q2QY04; -.
DR   OMA; WAREYFI; -.
DR   OrthoDB; 1348942at2759; -.
DR   Proteomes; UP000000763; Chromosome 12.
DR   Proteomes; UP000007752; Chromosome 12.
DR   Proteomes; UP000059680; Chromosome 12.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR   GO; GO:0035303; P:regulation of dephosphorylation; IBA:GO_Central.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.40.540; -; 1.
DR   InterPro; IPR038511; TAP42/TAP46-like_sf.
DR   InterPro; IPR007304; TAP46-like.
DR   PANTHER; PTHR10933; PTHR10933; 1.
DR   Pfam; PF04177; TAP42; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..418
FT                   /note="PP2A regulatory subunit TAP46"
FT                   /id="PRO_0000440567"
FT   REGION          367..418
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        380..409
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        159
FT                   /note="V -> A (in Ref. 1; AAO72555)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        273
FT                   /note="A -> G (in Ref. 6; EAZ19586)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  47220 MW;  E05CD1C962131ADB CRC64;
     MVEVEEVSNK MQAQMRLHPA AAAEEEDADL PLPALFDKAS HLHSLASSSS LDQEGIRKGV
     DLLRRCDEMV SKLGLFSSNE TKDDVSTANL KYLLVPYYLG EMTERVAQED RIPVLKASQD
     HLKEFISICE ALELISEDEL ELSRQKQPDT MANRRAQKVA RFKRQKAAET KLLEIKERKE
     RRRRSLRAAA LSAPIEAGEE DAFEDDGEEE REAWLATISL ALCKAFDLLD MLKKEEEMLL
     AVKERQAKDG NAFAREMLDE RTKKAEAWHH NAANRAPYSK PADPITCATF AQDVIEGRAS
     VSQAHEHKHQ PLIFGPASLV GGGLTSERER MAAQVFQPSY RLPTMSIEEA GLREMKMMEK
     WQERTAKMIQ ESNSAWHKDG SRSAQEDEDA EEEKARAWDD WKDDNPRGAG NKKLTPCG