ID   TAP46_TOBAC             Reviewed;         403 AA.
AC   A0A1S4D1D3;
DT   07-JUN-2017, integrated into UniProtKB/Swiss-Prot.
DT   12-APR-2017, sequence version 1.
DT   25-MAY-2022, entry version 20.
DE   RecName: Full=PP2A regulatory subunit TAP46 {ECO:0000303|PubMed:21216945};
GN   Name=TAP46 {ECO:0000303|PubMed:21216945};
OS   Nicotiana tabacum (Common tobacco).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae;
OC   Nicotiana.
OX   NCBI_TaxID=4097;
RN   [1]
RP   IDENTIFICATION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21216945; DOI=10.1105/tpc.110.074005;
RA   Ahn C.S., Han J.-A., Lee H.-S., Lee S., Pai H.-S.;
RT   "The PP2A regulatory subunit Tap46, a component of the TOR signaling
RT   pathway, modulates growth and metabolism in plants.";
RL   Plant Cell 23:185-209(2011).
RN   [2]
RP   ADDENDUM.
RX   PubMed=21597327; DOI=10.4161/psb.6.7.15651;
RA   Ahn C.S., Lee H.S., Pai H.S.;
RT   "Molecular functions of the PP2A regulatory subunit Tap46 in plants.";
RL   Plant Signal. Behav. 6:1067-1068(2011).
CC   -!- FUNCTION: Involved in the regulation of the TOR signaling pathway.
CC       Seems to act as a regulator of PP2A catalytic activity.
CC       {ECO:0000250|UniProtKB:D2K8N5}.
CC   -!- DISRUPTION PHENOTYPE: RNAi plants show severe growth retardation, the
CC       formation of spontaneous disease-like nectrotic lesions leading to
CC       premature cell death. The defective plants also display a strong
CC       reduction in protein synthesis, and chromatin bridge formation at
CC       anaphase. {ECO:0000269|PubMed:21216945}.
CC   -!- SIMILARITY: Belongs to the IGBP1/TAP42 family. {ECO:0000305}.
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DR   RefSeq; XP_016507074.1; XM_016651588.1.
DR   AlphaFoldDB; A0A1S4D1D3; -.
DR   SMR; A0A1S4D1D3; -.
DR   STRING; 4097.A0A1S4D1D3; -.
DR   GeneID; 107824781; -.
DR   KEGG; nta:107824781; -.
DR   OMA; CESKMED; -.
DR   OrthoDB; 1348942at2759; -.
DR   Proteomes; UP000084051; Unplaced.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0051721; F:protein phosphatase 2A binding; IBA:GO_Central.
DR   GO; GO:0035303; P:regulation of dephosphorylation; IBA:GO_Central.
DR   GO; GO:0009966; P:regulation of signal transduction; IEA:InterPro.
DR   Gene3D; 1.25.40.540; -; 1.
DR   InterPro; IPR038511; TAP42/TAP46-like_sf.
DR   InterPro; IPR007304; TAP46-like.
DR   PANTHER; PTHR10933; PTHR10933; 1.
DR   Pfam; PF04177; TAP42; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..403
FT                   /note="PP2A regulatory subunit TAP46"
FT                   /id="PRO_0000440568"
FT   REGION          158..184
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..403
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        376..394
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   403 AA;  45568 MW;  B59FE6D54654DDD2 CRC64;
     MGELSMQEMP LPALFEQGSK IHASAESSVD QDTVRKGCEI LRQCEEMIGK LGLFSVNETK
     EDISTANLKY ILVPYYLAEL TEKVADNDRI KVLKASQAKL KEFISFCETM ELVPEEEIET
     STQGGANSSV DRRAKKIARF KRQRAAESKL LEIKERKERR GRSTKAAALS SPVETEEDDV
     LDDDGEEERE AWLTTISLGL CKAFDLLEML KKEEEILSAV KEKQLQDGER EFSQAILDER
     TKKVETWHRD AAARAHHTKP AAPITCATFA QDVIEGRAKV SQAHEHKHQP LIFGPASLVG
     RNPTTEREKI AAQVFQPHYR LPTMSIEEAG LTEMNMMNEW QERNVKLMEE ANSSWYKDTP
     KSRPGEDDEE DDDDAAQDKA RAWDDWKDDN PRGAGNKKLT PCG