ID   BPPXA_PHAJA             Reviewed;          10 AA.
AC   P86643;
DT   08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   26-FEB-2020, entry version 10.
DE   RecName: Full=Bradykinin-potentiating peptide Phypo Xa {ECO:0000303|PubMed:20932854};
DE            Short=BPP;
OS   Phasmahyla jandaia (Jandaia leaf frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Phasmahyla.
OX   NCBI_TaxID=762504;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:20932854};
RX   PubMed=20932854; DOI=10.1016/j.toxicon.2010.09.010;
RA   Rates B., Silva L.P., Ireno I.C., Leite F.S., Borges M.H., Bloch C. Jr.,
RA   De Lima M.E., Pimenta A.M.;
RT   "Peptidomic dissection of the skin secretion of Phasmahyla jandaia
RT   (Bokermann and Sazima, 1978) (Anura, Hylidae, Phyllomedusinae).";
RL   Toxicon 57:35-52(2011).
CC   -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC       converting enzyme and enhances the action of bradykinin by inhibiting
CC       the peptidases that inactivate it. It acts as an indirect hypotensive
CC       agent (By similarity). {ECO:0000250|UniProtKB:P85165}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:20932854}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:20932854}.
CC   -!- MASS SPECTROMETRY: Mass=1214.9; Method=MALDI;
CC       Evidence={ECO:0000269|PubMed:20932854};
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..10
FT                   /note="Bradykinin-potentiating peptide Phypo Xa"
FT                   /evidence="ECO:0000269|PubMed:20932854"
FT                   /id="PRO_0000404637"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:20932854"
FT   UNSURE          8
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:20932854"
SQ   SEQUENCE   10 AA;  1232 MW;  7BED3546CB45A774 CRC64;
     QFRPSYQIPP