TAPR1_DANRE
ID TAPR1_DANRE Reviewed; 265 AA.
AC A2BE76; Q6P014; Q7ZU95;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Telomere attrition and p53 response 1 protein {ECO:0000250|UniProtKB:Q14CZ0};
GN Name=tapr1 {ECO:0000250|UniProtKB:Q14CZ0};
GN ORFNames=si:dkey-20i6.3, zgc:77849;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions as a negative regulator of TP53/P53 in the cellular
CC response to telomere erosion and probably also DNA damage.
CC {ECO:0000250|UniProtKB:Q14CZ0}.
CC -!- SIMILARITY: Belongs to the TAPR1 family. {ECO:0000305}.
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DR EMBL; BX005261; CAM13034.1; -; Genomic_DNA.
DR EMBL; BC050493; AAH50493.1; -; mRNA.
DR EMBL; BC065877; AAH65877.1; -; mRNA.
DR RefSeq; NP_955896.2; NM_199602.2.
DR AlphaFoldDB; A2BE76; -.
DR STRING; 7955.ENSDARP00000011098; -.
DR PaxDb; A2BE76; -.
DR GeneID; 322387; -.
DR KEGG; dre:322387; -.
DR ZFIN; ZDB-GENE-030131-1107; zgc:77849.
DR eggNOG; ENOG502QPPE; Eukaryota.
DR InParanoid; A2BE76; -.
DR OrthoDB; 1126238at2759; -.
DR PhylomeDB; A2BE76; -.
DR TreeFam; TF323292; -.
DR PRO; PR:A2BE76; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Unplaced.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IDA:ZFIN.
DR GO; GO:1901797; P:negative regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR InterPro; IPR040308; TAPR1.
DR InterPro; IPR029196; TAPR1-like.
DR PANTHER; PTHR31624; PTHR31624; 1.
DR Pfam; PF15251; DUF4588; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..265
FT /note="Telomere attrition and p53 response 1 protein"
FT /id="PRO_0000297629"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 194..219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..173
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..215
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 66
FT /note="D -> G (in Ref. 2; AAH50493)"
FT /evidence="ECO:0000305"
FT CONFLICT 162
FT /note="S -> P (in Ref. 2; AAH50493/AAH65877)"
FT /evidence="ECO:0000305"
FT CONFLICT 240
FT /note="G -> R (in Ref. 2; AAH50493)"
FT /evidence="ECO:0000305"
FT CONFLICT 260
FT /note="K -> E (in Ref. 2; AAH50493)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 265 AA; 29877 MW; 27407767E6EFC079 CRC64;
MEEKKEEGEA EIQEHGPEHW FSKWERQCLA EAEQEEPAEE ETDQSQQKLW HLFQNSATAV
AQLYKDRVCQ QQQGLSLWVP FQNAATAVTN LYKESVDAHQ RSYELGIQIG HQRRNKDVLA
WVKKRRRTIR REDLISFLCG KAPPPRSSRA PPRLAMVSPS RSTPSETSSS VETDLQPFRE
AIALHGLSGA MASISMRSGA PGSPTHLSAS SAPSRRRNGL HDVDLNTFIA EEMALHLDNG
TRKRSSAQCN DVITDSPTHK RNRMI
