ID   BPPXA_PITHY             Reviewed;          10 AA.
AC   P85165;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-JUN-2007, sequence version 1.
DT   02-DEC-2020, entry version 18.
DE   RecName: Full=Bradykinin-potentiating peptide Phypo Xa;
DE            Short=BPP;
OS   Pithecopus hypochondrialis (Orange-legged leaf frog) (Phyllomedusa
OS   hypochondrialis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Phyllomedusinae;
OC   Pithecopus.
OX   NCBI_TaxID=317381;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS
RP   SPECTROMETRY, AND PYROGLUTAMATE FORMATION AT GLN-1.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:17098329};
RX   PubMed=17098329; DOI=10.1016/j.peptides.2006.10.002;
RA   Conceicao K., Konno K., de Melo R.L., Antoniazzi M.M., Jared C.,
RA   Sciani J.M., Conceicao I.M., Prezoto B.C., de Camargo A.C.M., Pimenta D.C.;
RT   "Isolation and characterization of a novel bradykinin potentiating peptide
RT   (BPP) from the skin secretion of Phyllomedusa hypochondrialis.";
RL   Peptides 28:515-523(2007).
CC   -!- FUNCTION: This peptide both inhibits the activity of the angiotensin-
CC       converting enzyme and enhances the action of bradykinin by inhibiting
CC       the peptidases that inactivate it. It acts as an indirect hypotensive
CC       agent. {ECO:0000269|PubMed:17098329}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:17098329}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000269|PubMed:17098329}.
CC   -!- MASS SPECTROMETRY: Mass=1214.62; Mass_error=0.05; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17098329};
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Pyrrolidone carboxylic acid;
KW   Secreted; Toxin.
FT   PEPTIDE         1..10
FT                   /note="Bradykinin-potentiating peptide Phypo Xa"
FT                   /evidence="ECO:0000269|PubMed:17098329"
FT                   /id="PRO_0000291534"
FT   MOD_RES         1
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:17098329"
SQ   SEQUENCE   10 AA;  1232 MW;  7BED3546CB45A774 CRC64;
     QFRPSYQIPP