ID   TAPR1_XENLA             Reviewed;         265 AA.
AC   Q6PAX8;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 38.
DE   RecName: Full=Telomere attrition and p53 response 1 protein {ECO:0000250|UniProtKB:Q14CZ0};
GN   Name=tapr1 {ECO:0000250|UniProtKB:Q14CZ0};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a negative regulator of TP53/P53 in the cellular
CC       response to telomere erosion and probably also DNA damage.
CC       {ECO:0000250|UniProtKB:Q14CZ0}.
CC   -!- SIMILARITY: Belongs to the TAPR1 family. {ECO:0000305}.
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DR   EMBL; BC060006; AAH60006.1; -; mRNA.
DR   RefSeq; NP_001083200.1; NM_001089731.1.
DR   AlphaFoldDB; Q6PAX8; -.
DR   DNASU; 398798; -.
DR   GeneID; 398798; -.
DR   KEGG; xla:398798; -.
DR   CTD; 398798; -.
DR   Xenbase; XB-GENE-957514; c16orf72.S.
DR   OMA; GARPEHC; -.
DR   OrthoDB; 1126238at2759; -.
DR   Proteomes; UP000186698; Chromosome 9_10S.
DR   Bgee; 398798; Expressed in testis and 19 other tissues.
DR   GO; GO:1901797; P:negative regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   InterPro; IPR040308; TAPR1.
DR   InterPro; IPR029196; TAPR1-like.
DR   PANTHER; PTHR31624; PTHR31624; 1.
DR   Pfam; PF15251; DUF4588; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Telomere attrition and p53 response 1 protein"
FT                   /id="PRO_0000297630"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29855 MW;  8078301A998CB115 CRC64;
     MEDKKEEGES EIQEHGPEHW FSKWERQCLA EAEQEDQPEE EAEQSQQKLW HLFQNSATAV
     AQLYKDRVCQ QQGLSLWVPF QNAATAVTNL YKESVDAHQR SFDLGIQIGY QRRNKDVLAW
     VKKRRRTIRR EDLISFLCGK VPPPRNSRAP PRLTVVSPNR ATPTETGSSV ETDLQPFREA
     IALHGLSGAM ASISVRSSTP GSPTHVSGSS NTGRRRNGLH DVDLNTFISE EMALHLDNGG
     TRKRSSAQCG DVITDSPTHK RNRMI