ID   TAPR1_XENTR             Reviewed;         265 AA.
AC   Q28HY5;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Telomere attrition and p53 response 1 protein {ECO:0000250|UniProtKB:Q14CZ0};
GN   Name=tapr1 {ECO:0000250|UniProtKB:Q14CZ0}; ORFNames=TEgg029f10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Functions as a negative regulator of TP53/P53 in the cellular
CC       response to telomere erosion and probably also DNA damage.
CC       {ECO:0000250|UniProtKB:Q14CZ0}.
CC   -!- SIMILARITY: Belongs to the TAPR1 family. {ECO:0000305}.
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DR   EMBL; CR760682; CAJ82206.1; -; mRNA.
DR   RefSeq; NP_001016564.1; NM_001016564.2.
DR   RefSeq; XP_017952597.1; XM_018097108.1.
DR   AlphaFoldDB; Q28HY5; -.
DR   STRING; 8364.ENSXETP00000019036; -.
DR   PaxDb; Q28HY5; -.
DR   DNASU; 549318; -.
DR   Ensembl; ENSXETT00000019036; ENSXETP00000019036; ENSXETG00000008699.
DR   GeneID; 549318; -.
DR   KEGG; xtr:549318; -.
DR   CTD; 29035; -.
DR   Xenbase; XB-GENE-957508; c16orf72.
DR   eggNOG; ENOG502QPPE; Eukaryota.
DR   HOGENOM; CLU_081329_0_0_1; -.
DR   InParanoid; Q28HY5; -.
DR   OMA; GARPEHC; -.
DR   OrthoDB; 1126238at2759; -.
DR   PhylomeDB; Q28HY5; -.
DR   TreeFam; TF323292; -.
DR   Proteomes; UP000008143; Chromosome 9.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000008699; Expressed in blastula and 15 other tissues.
DR   GO; GO:1901797; P:negative regulation of signal transduction by p53 class mediator; ISS:UniProtKB.
DR   InterPro; IPR040308; TAPR1.
DR   InterPro; IPR029196; TAPR1-like.
DR   PANTHER; PTHR31624; PTHR31624; 1.
DR   Pfam; PF15251; DUF4588; 1.
PE   2: Evidence at transcript level;
KW   Reference proteome.
FT   CHAIN           1..265
FT                   /note="Telomere attrition and p53 response 1 protein"
FT                   /id="PRO_0000297631"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          145..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          195..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          240..265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        195..215
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        241..255
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   265 AA;  29869 MW;  8078301A9C8CE115 CRC64;
     MEDKKEEGES EIQEHGPEHW FSKWERQCLA EAEQEDQPEE EAEQSQQKLW HLFQNSATAV
     AQLYKDRVCQ QQGLSLWVPF QNAATAVTNL YKESVDAHQR SFDLGIQIGY QRRNKDVLAW
     VKKRRRTIRR EDLISFLCGK VPPPRNSRAP PRLTVVSPNR ATPTETGSSV ETDLQPFREA
     IALHGLSGAM ASISVRSSTP GSPTHVSGSS NTGRRRNGLH DVDLNTFISE EMALHLDNGG
     TRKRTSAQCG DVITDSPTHK RNRMI