ID   TAPT1_CHICK             Reviewed;         581 AA.
AC   Q5ZLG8;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 2.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transmembrane anterior posterior transformation protein 1 homolog;
GN   Name=TAPT1; ORFNames=RCJMB04_6d24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Plays a role in primary cilia formation. May act as a
CC       downstream effector of HOXC8 during development. May be involved in
CC       cartilage and bone development. May play a role in the differentiation
CC       of cranial neural crest cells. {ECO:0000250|UniProtKB:A2BIE7,
CC       ECO:0000250|UniProtKB:Q4VBD2, ECO:0000250|UniProtKB:Q6NXT6}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q6NXT6}. Cytoplasm,
CC       cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:Q6NXT6}.
CC       Membrane {ECO:0000250|UniProtKB:Q6NXT6}; Multi-pass membrane protein
CC       {ECO:0000250|UniProtKB:Q6NXT6}.
CC   -!- SIMILARITY: Belongs to the TAPT1 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAG31425.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AJ719766; CAG31425.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001026332.2; NM_001031161.2.
DR   AlphaFoldDB; Q5ZLG8; -.
DR   SMR; Q5ZLG8; -.
DR   STRING; 9031.ENSGALP00000036511; -.
DR   PaxDb; Q5ZLG8; -.
DR   GeneID; 422824; -.
DR   KEGG; gga:422824; -.
DR   CTD; 202018; -.
DR   VEuPathDB; HostDB:geneid_422824; -.
DR   eggNOG; KOG2490; Eukaryota.
DR   HOGENOM; CLU_003655_3_0_1; -.
DR   InParanoid; Q5ZLG8; -.
DR   OrthoDB; 572763at2759; -.
DR   PhylomeDB; Q5ZLG8; -.
DR   PRO; PR:Q5ZLG8; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005813; C:centrosome; ISS:UniProtKB.
DR   GO; GO:0036064; C:ciliary basal body; ISS:UniProtKB.
DR   GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IEA:UniProtKB-KW.
DR   GO; GO:0030030; P:cell projection organization; IEA:UniProtKB-KW.
DR   GO; GO:0035437; P:maintenance of protein localization in endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0014032; P:neural crest cell development; ISS:UniProtKB.
DR   GO; GO:0001503; P:ossification; IEA:UniProtKB-KW.
DR   GO; GO:1903012; P:positive regulation of bone development; ISS:UniProtKB.
DR   GO; GO:0061036; P:positive regulation of cartilage development; ISS:UniProtKB.
DR   GO; GO:0045724; P:positive regulation of cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR008010; Tatp1.
DR   PANTHER; PTHR13317; PTHR13317; 1.
DR   Pfam; PF05346; DUF747; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Chondrogenesis; Cilium; Cilium biogenesis/degradation;
KW   Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Membrane;
KW   Osteogenesis; Reference proteome; Transmembrane; Transmembrane helix.
FT   CHAIN           1..581
FT                   /note="Transmembrane anterior posterior transformation
FT                   protein 1 homolog"
FT                   /id="PRO_0000328874"
FT   TRANSMEM        125..145
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        182..202
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        250..270
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        417..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        439..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          484..563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        501..542
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        543..563
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  65775 MW;  743014E11B8CCCC5 CRC64;
     MAGVSDAAAP GSGGEGRRGG GGSPEQLQQD GCRGEPKTLW GSSELRPPPA GPGQPSPHQR
     TETLGFYESD RGRKKKRGLS DLSLLRFISA ELTRGYFLEH NEAKYTERRE RVYTCMRIPK
     ELEKLMFFGI FLCLDAFLYI FTLLPLRVFL AMFRFITLPC YGLRDRRLLQ PAQVCDILKG
     VILVICYFMM HYVDYSMMYH LIRGQSVIKL YIIYNMLEVA DRLFSSFGQD ILDALYWTAT
     EPKERKRAHI GVIPHFFMAV LYVFLHAILI MVQATTLNVA FNSHNKSLLT IMMSNNFVEI
     KGSVFKKFEK NNLFQMSNSD IKERFTNYVL LLIVCLRNME QFSWNPDHLW VLFPDVCMVV
     ASEIAVDIVK HAFITKFNDI TADVYSEYRA SLAFDLVSSR QKNAYTDYSD SVSRRMGFIP
     LPLAVLLMRV VTSSIKVQGV LAYVCVVLFY CGLISLKVLN SIVLLGKSCQ YVKEAKMEEK
     LFNPVPSASA GKPAGKPQSM FKSTHGFSTD ENGSTSVTNQ PVHQKDSPPS LLVTSNSDQF
     LTTPDGEEKD ISQDSSELKH RSSKKDLLEI DRFTICGNRI D