TAPT1_DROME
ID TAPT1_DROME Reviewed; 676 AA.
AC Q9VED0;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Protein TAPT1 homolog;
GN ORFNames=CG7218;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the TAPT1 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014297; AAF55495.2; -; Genomic_DNA.
DR EMBL; AY058285; AAL13514.1; -; mRNA.
DR RefSeq; NP_001287385.1; NM_001300456.1.
DR RefSeq; NP_650678.1; NM_142421.4.
DR AlphaFoldDB; Q9VED0; -.
DR SMR; Q9VED0; -.
DR IntAct; Q9VED0; 3.
DR STRING; 7227.FBpp0083043; -.
DR PaxDb; Q9VED0; -.
DR PRIDE; Q9VED0; -.
DR DNASU; 42165; -.
DR EnsemblMetazoa; FBtr0083623; FBpp0083043; FBgn0038569.
DR EnsemblMetazoa; FBtr0344646; FBpp0310956; FBgn0038569.
DR GeneID; 42165; -.
DR KEGG; dme:Dmel_CG7218; -.
DR UCSC; CG7218-RA; d. melanogaster.
DR FlyBase; FBgn0038569; CG7218.
DR VEuPathDB; VectorBase:FBgn0038569; -.
DR eggNOG; KOG2490; Eukaryota.
DR GeneTree; ENSGT00390000010628; -.
DR HOGENOM; CLU_003655_3_1_1; -.
DR InParanoid; Q9VED0; -.
DR OMA; YDMTQTR; -.
DR OrthoDB; 572763at2759; -.
DR PhylomeDB; Q9VED0; -.
DR BioGRID-ORCS; 42165; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 42165; -.
DR PRO; PR:Q9VED0; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038569; Expressed in testis and 28 other tissues.
DR ExpressionAtlas; Q9VED0; baseline and differential.
DR Genevisible; Q9VED0; DM.
DR GO; GO:0036064; C:ciliary basal body; IBA:GO_Central.
DR GO; GO:0030176; C:integral component of endoplasmic reticulum membrane; IBA:GO_Central.
DR GO; GO:0035437; P:maintenance of protein localization in endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0045724; P:positive regulation of cilium assembly; IBA:GO_Central.
DR InterPro; IPR008010; Tatp1.
DR PANTHER; PTHR13317; PTHR13317; 1.
DR Pfam; PF05346; DUF747; 1.
PE 2: Evidence at transcript level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix.
FT CHAIN 1..676
FT /note="Protein TAPT1 homolog"
FT /id="PRO_0000328878"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 414..434
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 437..457
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 17..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 75566 MW; 2627B9B2711971D6 CRC64;
MNATLNSAGG KRQLRFRGDV TGSRVEELHH QQQEEQKQKA PLAQDDVAAT PTATPAAGSA
QQRLQSGTAE TCTNTFYDFF KVEMTRGYML EHDEERYSAR RQKIYSFMRI PRDLERFMVY
GIMQCADSFL YIHTFLPVRF VMAVWALVSR TVARIFRLRS SGQRLLSPAE ICDLLKGVIW
MTVTLIMLLV DTNRVYHIIK SQSIIKLYIF YNMLEVGDRL LSAFGQDTID ALFWTATEPK
NSKREHFGVL THVLFTLIYV FLHSGLIMFQ ATCLNVAVNS NNKGLLTIMI SNNFVELKGS
VFKKFDKNNL FQLTCSDVRE RFHLSVLLFI VVIQTMKEFD WSITQFCVML PDCFAVLFTE
ILIDWVKHAF ITRFNELPES IYREYTTSLA YDMTQTRQKH AFSDHSDLVA RRMGFIPFPL
AVVLIKAIYT AVSFENLAAW LLFLLAYLFA MGLRICLTIC ALGKACKLMK EHQTERNSST
PSSMTNVPVI GAAAPVSAAA TGGQNHNNNN NNNNNSISIG SKPAQVTTLL TPPSAGHLDV
SKNFSRTSIA STSTPKKAVS EQELDVTNSL ELGATALFSN SDVDLDDVCL NEQVTNTNTS
SAVQEVYQEQ DLVRSQPDLM LLNNSGDGVT SAKAKKATQR LPKRTHKRSE SEPGMPSMVE
KGGAAGIAGG NQTTQL
