ID   BPP_BITRH               Reviewed;          12 AA.
AC   P0DV80;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   25-MAY-2022, sequence version 1.
DT   03-AUG-2022, entry version 2.
DE   RecName: Full=Bradykinin-potentiating peptide 10 g-AP {ECO:0000305|PubMed:28670326};
DE            Short=BPP-10 g-AP {ECO:0000303|PubMed:28670326};
OS   Bitis rhinoceros (West African gaboon viper) (Vipera rhinoceros).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Serpentes; Colubroidea; Viperidae; Viperinae; Bitis.
OX   NCBI_TaxID=715877;
RN   [1]
RP   PROTEIN SEQUENCE, FUNCTION, IDENTIFICATION BY MASS SPECTROMETRY,
RP   SUBCELLULAR LOCATION, AND SYNTHESIS.
RC   TISSUE=Venom;
RX   PubMed=28670326; DOI=10.1186/s40409-017-0124-9;
RA   Fucase T.M., Sciani J.M., Cavalcante I., Viala V.L., Chagas B.B.,
RA   Pimenta D.C., Spencer P.J.;
RT   "Isolation and biochemical characterization of bradykinin-potentiating
RT   peptides from Bitis gabonica rhinoceros.";
RL   J. Venom. Anim. Toxins Incl. Trop. Dis. 23:33-33(2017).
CC   -!- FUNCTION: Bradykinin-potentiating peptide (PubMed:28670326). Shows poor
CC       inhibition over ACE (Ki=1 mM) (PubMed:28670326). In vivo, potentiates
CC       bradykinin activity by increasing its edema-inducing activity in rat
CC       paw (PubMed:28670326). May also potentiate the hypotensive effects of
CC       bradykinin (Probable). {ECO:0000269|PubMed:28670326,
CC       ECO:0000305|PubMed:28670326}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:28670326}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000305|PubMed:28670326}.
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Secreted; Toxin.
FT   PEPTIDE         1..12
FT                   /note="Bradykinin-potentiating peptide 10 g-AP"
FT                   /evidence="ECO:0000269|PubMed:28670326"
FT                   /id="PRO_0000455655"
SQ   SEQUENCE   12 AA;  1287 MW;  7822701B02776864 CRC64;
     APQERGPPEI PP