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TAP_BPMU
ID   TAP_BPMU                Reviewed;         144 AA.
AC   P79680;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   23-FEB-2022, entry version 69.
DE   RecName: Full=Probable tail assembly protein gp41;
DE   AltName: Full=Gene product 41;
DE            Short=gp41;
DE   AltName: Full=Tail assembly chaperone;
GN   OrderedLocusNames=Mup41;
OS   Escherichia phage Mu (Bacteriophage Mu).
OC   Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC   Caudovirales; Myoviridae; Muvirus.
OX   NCBI_TaxID=10677;
OH   NCBI_TaxID=543; Enterobacteriaceae.
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9714755; DOI=10.1016/s0167-4781(98)00102-x;
RA   Takeda S., Sasaki T., Ritani A., Howe M.M., Arisaka F.;
RT   "Discovery of the tail tube gene of bacteriophage Mu and sequence analysis
RT   of the sheath and tube genes.";
RL   Biochim. Biophys. Acta 1399:88-92(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
RA   Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
RT   "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like
RT   prophages in Haemophilus, Neisseria and Deinococcus.";
RL   J. Mol. Biol. 317:337-359(2002).
RN   [3]
RP   INDUCTION.
RX   PubMed=8293968; DOI=10.1093/genetics/135.3.619;
RA   Chiang L.W., Howe M.M.;
RT   "Mutational analysis of a C-dependent late promoter of bacteriophage Mu.";
RL   Genetics 135:619-629(1993).
RN   [4]
RP   RIBOSOMAL FRAMESHIFT.
RX   PubMed=15469818; DOI=10.1016/j.molcel.2004.09.006;
RA   Xu J., Hendrix R.W., Duda R.L.;
RT   "Conserved translational frameshift in dsDNA bacteriophage tail assembly
RT   genes.";
RL   Mol. Cell 16:11-21(2004).
CC   -!- FUNCTION: Required for tail assembly (Probable). Together with FS-gp41,
CC       may act as a chaperone mediating the interaction between the tape
CC       measure protein (TMP) and the tail tube protein (TTP) thereby directing
CC       the polymerization of TTP to form a tail of the correct length
CC       (Potential). {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=Tail assembly chaperone gp41;
CC         IsoId=P79680-1; Sequence=Displayed;
CC       Name=Tail assembly chaperone FS-gp41;
CC         IsoId=P0DJY4-1; Sequence=External;
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       Expression of late genes is activated by the viral late transcription
CC       activator C. {ECO:0000269|PubMed:8293968}.
CC   -!- MISCELLANEOUS: [Isoform Tail assembly chaperone gp41]: Produced by
CC       conventional translation.
CC   -!- SIMILARITY: Belongs to the mulikevirus tail assembly protein family.
CC       {ECO:0000305}.
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DR   EMBL; AB000833; BAA19197.1; -; Genomic_DNA.
DR   EMBL; AF083977; AAF01119.1; -; Genomic_DNA.
DR   RefSeq; NP_050645.1; NC_000929.1.
DR   GeneID; 2636287; -.
DR   KEGG; vg:2636287; -.
DR   Proteomes; UP000002611; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR   InterPro; IPR019289; Phage_tail_Gp41_put.
DR   Pfam; PF10109; Phage_TAC_7; 1.
PE   2: Evidence at transcript level;
KW   Host cytoplasm; Late protein; Reference proteome; Ribosomal frameshifting;
KW   Viral release from host cell; Viral tail assembly.
FT   CHAIN           1..144
FT                   /note="Probable tail assembly protein gp41"
FT                   /id="PRO_0000077834"
SQ   SEQUENCE   144 AA;  15584 MW;  1C54C05E8E11C2F2 CRC64;
     MDEMNLGPEA QELHDSIVAE IQSGVLKLKD GLPFGTGDET EMQYDVTLRE LTAGDMIDAQ
     AAAEKLVMSK EGPVLVSSPS RMGLEMLRRQ IASVGCIKGP LSMALIRKLS VDDFQRLSLA
     TEMYDMAVAA SLTQERGRVA AVPE
 
 
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