TAP_BPMU
ID TAP_BPMU Reviewed; 144 AA.
AC P79680;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 23-FEB-2022, entry version 69.
DE RecName: Full=Probable tail assembly protein gp41;
DE AltName: Full=Gene product 41;
DE Short=gp41;
DE AltName: Full=Tail assembly chaperone;
GN OrderedLocusNames=Mup41;
OS Escherichia phage Mu (Bacteriophage Mu).
OC Viruses; Duplodnaviria; Heunggongvirae; Uroviricota; Caudoviricetes;
OC Caudovirales; Myoviridae; Muvirus.
OX NCBI_TaxID=10677;
OH NCBI_TaxID=543; Enterobacteriaceae.
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9714755; DOI=10.1016/s0167-4781(98)00102-x;
RA Takeda S., Sasaki T., Ritani A., Howe M.M., Arisaka F.;
RT "Discovery of the tail tube gene of bacteriophage Mu and sequence analysis
RT of the sheath and tube genes.";
RL Biochim. Biophys. Acta 1399:88-92(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11922669; DOI=10.1006/jmbi.2002.5437;
RA Morgan G.J., Hatfull G.F., Casjens S., Hendrix R.W.;
RT "Bacteriophage Mu genome sequence: analysis and comparison with Mu-like
RT prophages in Haemophilus, Neisseria and Deinococcus.";
RL J. Mol. Biol. 317:337-359(2002).
RN [3]
RP INDUCTION.
RX PubMed=8293968; DOI=10.1093/genetics/135.3.619;
RA Chiang L.W., Howe M.M.;
RT "Mutational analysis of a C-dependent late promoter of bacteriophage Mu.";
RL Genetics 135:619-629(1993).
RN [4]
RP RIBOSOMAL FRAMESHIFT.
RX PubMed=15469818; DOI=10.1016/j.molcel.2004.09.006;
RA Xu J., Hendrix R.W., Duda R.L.;
RT "Conserved translational frameshift in dsDNA bacteriophage tail assembly
RT genes.";
RL Mol. Cell 16:11-21(2004).
CC -!- FUNCTION: Required for tail assembly (Probable). Together with FS-gp41,
CC may act as a chaperone mediating the interaction between the tape
CC measure protein (TMP) and the tail tube protein (TTP) thereby directing
CC the polymerization of TTP to form a tail of the correct length
CC (Potential). {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Ribosomal frameshifting; Named isoforms=2;
CC Name=Tail assembly chaperone gp41;
CC IsoId=P79680-1; Sequence=Displayed;
CC Name=Tail assembly chaperone FS-gp41;
CC IsoId=P0DJY4-1; Sequence=External;
CC -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC Expression of late genes is activated by the viral late transcription
CC activator C. {ECO:0000269|PubMed:8293968}.
CC -!- MISCELLANEOUS: [Isoform Tail assembly chaperone gp41]: Produced by
CC conventional translation.
CC -!- SIMILARITY: Belongs to the mulikevirus tail assembly protein family.
CC {ECO:0000305}.
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DR EMBL; AB000833; BAA19197.1; -; Genomic_DNA.
DR EMBL; AF083977; AAF01119.1; -; Genomic_DNA.
DR RefSeq; NP_050645.1; NC_000929.1.
DR GeneID; 2636287; -.
DR KEGG; vg:2636287; -.
DR Proteomes; UP000002611; Genome.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0098003; P:viral tail assembly; IEA:UniProtKB-KW.
DR InterPro; IPR019289; Phage_tail_Gp41_put.
DR Pfam; PF10109; Phage_TAC_7; 1.
PE 2: Evidence at transcript level;
KW Host cytoplasm; Late protein; Reference proteome; Ribosomal frameshifting;
KW Viral release from host cell; Viral tail assembly.
FT CHAIN 1..144
FT /note="Probable tail assembly protein gp41"
FT /id="PRO_0000077834"
SQ SEQUENCE 144 AA; 15584 MW; 1C54C05E8E11C2F2 CRC64;
MDEMNLGPEA QELHDSIVAE IQSGVLKLKD GLPFGTGDET EMQYDVTLRE LTAGDMIDAQ
AAAEKLVMSK EGPVLVSSPS RMGLEMLRRQ IASVGCIKGP LSMALIRKLS VDDFQRLSLA
TEMYDMAVAA SLTQERGRVA AVPE