TAP_DROME
ID TAP_DROME Reviewed; 398 AA.
AC O16867; P91640; Q9VVF9;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1999, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Basic helix-loop-helix neural transcription factor TAP;
DE AltName: Full=Protein biparous;
DE AltName: Full=Target of Poxn protein;
GN Name=tap; Synonyms=bps; ORFNames=CG7659;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=8954743; DOI=10.1006/dbio.1996.0344;
RA Bush A.B., Hiromi Y.H., Cole M.D.;
RT "Biparous: a novel bHLH gene expressed in neuronal and glial precursors in
RT Drosophila.";
RL Dev. Biol. 180:759-772(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R;
RX PubMed=9210583; DOI=10.1016/s0378-1119(97)00021-8;
RA Gautier P., Ledent V., Massaer M., Dambly-Chaudiere C., Ghysen A.;
RT "tap, a Drosophila bHLH gene expressed in chemosensory organs.";
RL Gene 191:15-21(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Oregon-R;
RX PubMed=9551861;
RA Ledent V., Gaillard F., Gautier P., Ghysen A., Dambly-Chaudiere C.;
RT "Expression and function of tap in the gustatory and olfactory organs of
RT Drosophila.";
RL Int. J. Dev. Biol. 42:163-170(1998).
CC -!- FUNCTION: May play a role in the specification of the sugar-sensitive
CC adult gustatory neuron and affect the response to sugar and salt.
CC Regulated by POXN. {ECO:0000269|PubMed:8954743,
CC ECO:0000269|PubMed:9210583, ECO:0000269|PubMed:9551861}.
CC -!- INTERACTION:
CC O16867; Q01069: E(spl)mbeta-HLH; NbExp=3; IntAct=EBI-102737, EBI-94554;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
CC -!- TISSUE SPECIFICITY: Expressed in neuronal and glial precursors during
CC differentiation. In the peripheral nervous system, expression is
CC exclusively in one of the neurons that innervate each larval
CC chemosensory organ. Expressed at a late stage in the development of one
CC type of adult chemosensory organ, the gustatory bristles of the leg,
CC wing and proboscis. Expressed very early in the development of a second
CC type of chemosensory receptors, the olfactory organs of the antenna.
CC {ECO:0000269|PubMed:8954743, ECO:0000269|PubMed:9210583,
CC ECO:0000269|PubMed:9551861}.
CC -!- DEVELOPMENTAL STAGE: Expressed in embryos, expression continues to the
CC final stages of neurogenesis. {ECO:0000269|PubMed:8954743}.
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DR EMBL; AF022883; AAC80572.1; -; mRNA.
DR EMBL; X95845; CAA65103.1; -; mRNA.
DR EMBL; AE014296; AAF49352.1; -; Genomic_DNA.
DR EMBL; AY119146; AAM51006.1; -; mRNA.
DR RefSeq; NP_524124.1; NM_079400.3.
DR AlphaFoldDB; O16867; -.
DR SMR; O16867; -.
DR BioGRID; 65225; 15.
DR DIP; DIP-21817N; -.
DR IntAct; O16867; 11.
DR STRING; 7227.FBpp0074978; -.
DR PaxDb; O16867; -.
DR DNASU; 39935; -.
DR EnsemblMetazoa; FBtr0075216; FBpp0074978; FBgn0015550.
DR GeneID; 39935; -.
DR KEGG; dme:Dmel_CG7659; -.
DR CTD; 39935; -.
DR FlyBase; FBgn0015550; tap.
DR VEuPathDB; VectorBase:FBgn0015550; -.
DR eggNOG; KOG3898; Eukaryota.
DR GeneTree; ENSGT00940000169303; -.
DR HOGENOM; CLU_693114_0_0_1; -.
DR InParanoid; O16867; -.
DR OMA; KRKYAVG; -.
DR OrthoDB; 1442051at2759; -.
DR PhylomeDB; O16867; -.
DR BioGRID-ORCS; 39935; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 39935; -.
DR PRO; PR:O16867; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0015550; Expressed in anlage in statu nascendi and 31 other tissues.
DR Genevisible; O16867; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IMP:FlyBase.
DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase.
DR GO; GO:0048843; P:negative regulation of axon extension involved in axon guidance; IMP:FlyBase.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007423; P:sensory organ development; TAS:FlyBase.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR032666; TAP-like.
DR PANTHER; PTHR19290:SF134; PTHR19290:SF134; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..398
FT /note="Basic helix-loop-helix neural transcription factor
FT TAP"
FT /id="PRO_0000127459"
FT DOMAIN 154..206
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 35..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 102..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 303..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 398 AA; 44851 MW; 54FF558483B18258 CRC64;
MAACYNAYSA GSQSFEFDED DDDASFDSGY EKSFETEAQL SSRRRLDFGT PPTPAIPQPY
SGGTWDAVPL SSPPAGFVGL LDTSSNHSTR SGRTLVEHLN SRATNGVFDP PLTSTPVKSP
EDPNAPRPKR KYAVGKNRVT RSRSPTQVVK IKRFRRMKAN DRERNRMHNL NDALEKLRVT
LPSLPEETKL TKIEILRFAH NYIFALEQVL ESGGSINLDL EKLQNFTLSG ERITKELFDA
LFVNPQPYPL FGRMFPYGQG MAPLAQHQTA PASHAEQPPA MGGFQHGMDY PQQPPGFDFT
GSMRFYHQQQ QQPHQPHHLQ PNPQQESSPQ QFSQEKYDLF RGSFDAAANL HSTNLDSGIH
QQSSFYSQTP PWKDYPEDQA HVHPVPHQHS YKNFAPQV
