ID   BPP_CHIQU               Reviewed;          10 AA.
AC   P0DQQ8;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   29-SEP-2021, sequence version 1.
DT   23-FEB-2022, entry version 2.
DE   RecName: Full=Angiotensin-converting enzyme inhibitory peptide {ECO:0000303|PubMed:27163886};
DE            Short=ACE inhibitory peptide {ECO:0000303|PubMed:27163886};
OS   Chiropsoides quadrigatus (Box jellyfish) (Chiropsalmus quadrigatus).
OC   Eukaryota; Metazoa; Cnidaria; Cubozoa; Chirodropida; Chiropsalmidae;
OC   Chiropsoides.
OX   NCBI_TaxID=130731;
RN   [1]
RP   PROTEIN SEQUENCE, MASS SPECTROMETRY, SUBCELLULAR LOCATION, AND FUNCTION.
RC   TISSUE=Tentacle;
RX   PubMed=27163886; DOI=10.1016/j.toxicon.2016.04.050;
RA   So P.B., Rubio P., Lirio S., Macabeo A.P., Huang H.Y., Corpuz M.J.,
RA   Villaflores O.B.;
RT   "In vitro angiotensin I converting enzyme inhibition by a peptide isolated
RT   from Chiropsalmus quadrigatus Haeckel (box jellyfish) venom hydrolysate.";
RL   Toxicon 119:77-83(2016).
CC   -!- FUNCTION: Inhibits the angiotensin-converting enzyme (ACE) (IC(50)=2.03
CC       uM) (PubMed:27163886). May act as an indirect hypotensive agent
CC       (Probable). In vivo, is not toxic and does not induce lesions and
CC       microscopic abnormalitie in rat liver (PubMed:27163886).
CC       {ECO:0000269|PubMed:27163886, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:27163886}.
CC       Nematocyst {ECO:0000269|PubMed:27163886}.
CC   -!- MASS SPECTROMETRY: Mass=966.099; Method=MALDI; Note=Average mass.;
CC       Evidence={ECO:0000269|PubMed:27163886};
CC   -!- SIMILARITY: Belongs to the bradykinin-potentiating peptide family.
CC       {ECO:0000305}.
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DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042151; C:nematocyst; IEA:UniProtKB-SubCell.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Hypotensive agent; Nematocyst; Secreted.
FT   PEPTIDE         1..10
FT                   /note="Angiotensin-converting enzyme inhibitory peptide"
FT                   /evidence="ECO:0000269|PubMed:27163886"
FT                   /id="PRO_0000453747"
SQ   SEQUENCE   10 AA;  965 MW;  25AB0D6764576867 CRC64;
     ACPGPNPGRP