ID   TARA_BACSH              Reviewed;         257 AA.
AC   Q8RKI7; B7ZDK9; E0U4X5;
DT   16-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase {ECO:0000255|HAMAP-Rule:MF_02070};
DE            EC=2.4.1.187 {ECO:0000250|UniProtKB:P27620, ECO:0000255|HAMAP-Rule:MF_02070};
DE   AltName: Full=N-acetylmannosaminyltransferase {ECO:0000255|HAMAP-Rule:MF_02070};
DE   AltName: Full=UDP-N-acetylmannosamine transferase {ECO:0000255|HAMAP-Rule:MF_02070};
DE   AltName: Full=UDP-N-acetylmannosamine:N-acetylglucosaminyl pyrophosphorylundecaprenol N-acetylmannosaminyltransferase {ECO:0000255|HAMAP-Rule:MF_02070};
GN   Name=tarA {ECO:0000303|PubMed:11882717}; OrderedLocusNames=BSUW23_17555;
OS   Bacillus spizizenii (strain ATCC 23059 / NRRL B-14472 / W23) (Bacillus
OS   subtilis subsp. spizizenii).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX   NCBI_TaxID=655816;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PUTATIVE FUNCTION.
RC   STRAIN=ATCC 23059 / NRRL B-14472 / W23;
RX   PubMed=11882717; DOI=10.1099/00221287-148-3-815;
RA   Lazarevic V., Abellan F.-X., Beggah Moeller S., Karamata D., Maueel C.;
RT   "Comparison of ribitol and glycerol teichoic acid genes in Bacillus
RT   subtilis W23 and 168: identical function, similar divergent organization,
RT   but different regulation.";
RL   Microbiology 148:815-824(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 23059 / NRRL B-14472 / W23;
RA   Soldo B., Freymond P.P., Karamata D., Lazarevic V.;
RT   "Minor teichoic acid of Bacillus subtilis W23.";
RL   Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 23059 / NRRL B-14472 / W23;
RX   PubMed=21527469; DOI=10.1099/mic.0.048520-0;
RA   Zeigler D.R.;
RT   "The genome sequence of Bacillus subtilis subsp. spizizenii W23: insights
RT   into speciation within the B. subtilis complex and into the history of B.
RT   subtilis genetics.";
RL   Microbiology 157:2033-2041(2011).
CC   -!- FUNCTION: Catalyzes the conversion of GlcNAc-PP-undecaprenol into
CC       ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate
CC       in the de novo synthesis of teichoic acid. {ECO:0000255|HAMAP-
CC       Rule:MF_02070}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=N-acetyl-alpha-D-glucosaminyl-di-trans,octa-cis-undecaprenyl
CC         diphosphate + UDP-N-acetyl-alpha-D-mannosamine = H(+) + N-acetyl-
CC         beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-
CC         trans,octa-cis-undecaprenyl diphosphate + UDP; Xref=Rhea:RHEA:16053,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58223, ChEBI:CHEBI:62959,
CC         ChEBI:CHEBI:68623, ChEBI:CHEBI:132210; EC=2.4.1.187;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_02070};
CC   -!- PATHWAY: Cell wall biogenesis; poly(ribitol phosphate) teichoic acid
CC       biosynthesis. {ECO:0000305|PubMed:11882717}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 26 family. TagA/TarA
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_02070}.
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DR   EMBL; AJ313428; CAC86111.1; -; Genomic_DNA.
DR   EMBL; AM260209; CAJ97398.1; -; Genomic_DNA.
DR   EMBL; CP002183; ADM39546.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8RKI7; -.
DR   SMR; Q8RKI7; -.
DR   CAZy; GT26; Glycosyltransferase Family 26.
DR   PRIDE; Q8RKI7; -.
DR   EnsemblBacteria; ADM39546; ADM39546; BSUW23_17555.
DR   KEGG; bss:BSUW23_17555; -.
DR   HOGENOM; CLU_063203_3_1_9; -.
DR   OMA; PWRWRRM; -.
DR   BioCyc; MetaCyc:MON-19961; -.
DR   UniPathway; UPA00790; -.
DR   Proteomes; UP000002233; Chromosome.
DR   GO; GO:0047244; F:N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-beta-D-mannosaminyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0019350; P:teichoic acid biosynthetic process; IEA:UniProtKB-UniRule.
DR   CDD; cd06533; Glyco_transf_WecG_TagA; 1.
DR   HAMAP; MF_02070; TagA_TarA; 1.
DR   InterPro; IPR034714; TagA_TarA.
DR   InterPro; IPR004629; WecG_TagA_CpsF.
DR   PANTHER; PTHR34136; PTHR34136; 1.
DR   Pfam; PF03808; Glyco_tran_WecG; 1.
DR   TIGRFAMs; TIGR00696; wecG_tagA_cpsF; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Glycosyltransferase;
KW   Teichoic acid biosynthesis; Transferase.
FT   CHAIN           1..257
FT                   /note="N-acetylglucosaminyldiphosphoundecaprenol N-acetyl-
FT                   beta-D-mannosaminyltransferase"
FT                   /id="PRO_0000208439"
SQ   SEQUENCE   257 AA;  29140 MW;  C10CE10C0337A56F CRC64;
     MQTKPINQLD FVDSELTSFV SHLETTYLDQ NKGAFIVTAN PEIGFEAMQN PRYEAVLSSA
     DFILPDGIGV VMVSKLIGKP LQSRIAGYDL FTSLLDKADQ KKKRVFFYGA AKHVIAETIE
     RVKRDFPGIE IAGYSDGYVK DQREVADKIA ASTPDMVFVA LGYPNQEFFI HKYRHLFPQA
     VAVGLGGSFD VFSGNVKRAP SFFIRFHLEW MYRLLTNPAR WRRMLSIPKY VTAVLKHERA
     SAKPHYTGQV KDQSRHL