ID   TARG1_XENTR             Reviewed;         179 AA.
AC   Q6DFT4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Trafficking regulator of GLUT4 1;
DE   AltName: Full=Dispanin subfamily B member 1;
DE            Short=DSPB1;
DE   AltName: Full=Tumor suppressor candidate 5 homolog;
GN   Name=trarg1; Synonyms=tusc5;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   GENE FAMILY.
RX   PubMed=22363774; DOI=10.1371/journal.pone.0031961;
RA   Sallman Almen M., Bringeland N., Fredriksson R., Schioth H.B.;
RT   "The dispanins: a novel gene family of ancient origin that contains 14
RT   human members.";
RL   PLoS ONE 7:E31961-E31961(2012).
CC   -!- FUNCTION: Regulates insulin-mediated adipose tissue glucose uptake and
CC       transport by modulation of SLC2A4 recycling.
CC       {ECO:0000250|UniProtKB:Q8C838}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q8C838};
CC       Single-pass membrane protein {ECO:0000250|UniProtKB:Q8C838}.
CC       Endomembrane system {ECO:0000250|UniProtKB:Q8C838}; Single-pass
CC       membrane protein {ECO:0000250|UniProtKB:Q8C838}. Cytoplasm, perinuclear
CC       region {ECO:0000250|UniProtKB:Q8C838}. Note=Shifts from low-density
CC       microsome vesicles to the cell membrane upon insulin stimulation.
CC       {ECO:0000250|UniProtKB:Q8C838}.
CC   -!- SIMILARITY: Belongs to the CD225/Dispanin family. {ECO:0000305}.
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DR   EMBL; BC076649; AAH76649.1; -; mRNA.
DR   RefSeq; NP_001005003.1; NM_001005003.1.
DR   AlphaFoldDB; Q6DFT4; -.
DR   STRING; 8364.ENSXETP00000054392; -.
DR   PaxDb; Q6DFT4; -.
DR   DNASU; 448489; -.
DR   Ensembl; ENSXETT00000054392; ENSXETP00000054392; ENSXETG00000025552.
DR   GeneID; 448489; -.
DR   KEGG; xtr:448489; -.
DR   CTD; 286753; -.
DR   Xenbase; XB-GENE-5890856; trarg1.
DR   eggNOG; ENOG502RY44; Eukaryota.
DR   HOGENOM; CLU_103195_0_0_1; -.
DR   InParanoid; Q6DFT4; -.
DR   OMA; SCFFPVW; -.
DR   OrthoDB; 1467259at2759; -.
DR   PhylomeDB; Q6DFT4; -.
DR   TreeFam; TF333012; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025552; Expressed in neurula embryo and 3 other tissues.
DR   GO; GO:0030659; C:cytoplasmic vesicle membrane; ISS:UniProtKB.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; ISS:UniProtKB.
DR   GO; GO:0099638; P:endosome to plasma membrane protein transport; ISS:UniProtKB.
DR   GO; GO:0044381; P:glucose import in response to insulin stimulus; ISS:UniProtKB.
DR   GO; GO:0072659; P:protein localization to plasma membrane; ISS:UniProtKB.
DR   InterPro; IPR007593; CD225/Dispanin_fam.
DR   Pfam; PF04505; CD225; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Cytoplasm; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..179
FT                   /note="Trafficking regulator of GLUT4 1"
FT                   /id="PRO_0000263642"
FT   TOPO_DOM        1..109
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8C838"
FT   INTRAMEM        110..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        131..157
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000250|UniProtKB:Q8C838"
FT   TRANSMEM        158..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        179
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000250|UniProtKB:Q8C838"
FT   REGION          1..47
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..43
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   179 AA;  19253 MW;  1EC1CF625D4AE673 CRC64;
     MAINTDTQYE KALGGSGNPL PADSHETEKL LTNASENKEE NGMKKSFSVT MSSEKSMGDL
     EQNGHNLPYK SVSAGQLESA PLSPSRVSLA RASSTATTAQ EQGRPTDYLV LAIFSCFCPV
     WPVNIVALVF SIMSRNSLQQ GDLDGARRLG RLARLLSVVS ILLGLVIIVL CILSLTIFH