TARM1_MOUSE
ID TARM1_MOUSE Reviewed; 288 AA.
AC B6A8R8;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=T-cell-interacting, activating receptor on myeloid cells protein 1;
DE AltName: Full=OSCAR-like transcript-2 protein;
DE Short=OLT-2;
DE Flags: Precursor;
GN Name=Tarm1; Synonyms=Gm9904;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J;
RA Barrow A.D., de Bono B., Trowsdale J.;
RT "Mus musculus OSCAR-like transcript-2 (OLT-2) mRNA.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=26311901; DOI=10.4049/jimmunol.1401847;
RA Radjabova V., Mastroeni P., Skjoedt K., Zaccone P., de Bono B.,
RA Goodall J.C., Chilvers E.R., Juss J.K., Jones D.C., Trowsdale J.,
RA Barrow A.D.;
RT "TARM1 is a novel leukocyte receptor complex-encoded ITAM receptor that
RT costimulates proinflammatory cytokine secretion by macrophages and
RT neutrophils.";
RL J. Immunol. 195:3149-3159(2015).
CC -!- FUNCTION: May act as receptor. Negatively regulates TCR-mediated CD4(+)
CC T cell proliferation and activation, possibly by binding an unknown
CC ligand on the T cell surface. Enhances Toll-like receptor-mediated
CC production of pro-inflammatory cytokines by macrophages and
CC neutrophils. {ECO:0000269|PubMed:26311901}.
CC -!- SUBUNIT: Interacts with Fc receptor gamma chain FCER1G.
CC {ECO:0000250|UniProtKB:B6A8C7}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26311901};
CC Single-pass type I membrane protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in lung, uterus, lymph nodes, spleen,
CC thymus and bone marrow. Expressed in bone marrow CD11b(+)Gr-1(+)
CC granulocyte precursors and mature neutrophils.
CC {ECO:0000269|PubMed:26311901}.
CC -!- INDUCTION: Up-regulated in CD11b(+)Ly6G(+) and CD11b(+)Ly6C(+)
CC neutrophils upon S.typhimurium bacterial infection. Up-regulated in
CC CD11b(+)Ly6C(intermediate)Ly6G(high)MHCI(-) neutrophils and
CC CD11b(+)Ly6C(high)Ly6G(low)MHCII(+) inflammatory monocytes in response
CC to TLR4 ligand lipopolysaccharide (LPS) stimulation. Up-regulated in
CC cultured macrophages and dendritic cells by TLR4 ligand LPS, TLR2-TLR6
CC ligand MALP-2 (a bacterial lipopeptide from M.fermentans), TLR1-TLR2
CC ligand Pam3CSK4 (a synthetic bacterial lipopeptide), TLR3 ligand
CC polyinosinic:polycytidylic acid (poly(I:C), a double-stranded RNA
CC synthetic analog) and TLR7 synthetic ligand imiquimod (R-837).
CC {ECO:0000269|PubMed:26311901}.
CC -!- PTM: N-glycosylated. {ECO:0000250|UniProtKB:B6A8C7}.
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DR EMBL; DQ973493; ABI79461.1; -; mRNA.
DR CCDS; CCDS39727.1; -.
DR RefSeq; NP_796337.1; NM_177363.3.
DR AlphaFoldDB; B6A8R8; -.
DR SMR; B6A8R8; -.
DR STRING; 10090.ENSMUSP00000069745; -.
DR GlyGen; B6A8R8; 2 sites.
DR PhosphoSitePlus; B6A8R8; -.
DR PaxDb; B6A8R8; -.
DR PRIDE; B6A8R8; -.
DR Antibodypedia; 65161; 80 antibodies from 15 providers.
DR DNASU; 245126; -.
DR Ensembl; ENSMUST00000203821; ENSMUSP00000145491; ENSMUSG00000053338.
DR GeneID; 245126; -.
DR KEGG; mmu:245126; -.
DR UCSC; uc009euz.1; mouse.
DR CTD; 441864; -.
DR MGI; MGI:2442280; Tarm1.
DR VEuPathDB; HostDB:ENSMUSG00000053338; -.
DR eggNOG; ENOG502RYEX; Eukaryota.
DR GeneTree; ENSGT01050000244944; -.
DR HOGENOM; CLU_021100_1_0_1; -.
DR InParanoid; B6A8R8; -.
DR PhylomeDB; B6A8R8; -.
DR TreeFam; TF336644; -.
DR Reactome; R-MMU-6798695; Neutrophil degranulation.
DR BioGRID-ORCS; 245126; 7 hits in 73 CRISPR screens.
DR ChiTaRS; Tarm1; mouse.
DR PRO; PR:B6A8R8; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; B6A8R8; protein.
DR Bgee; ENSMUSG00000053338; Expressed in granulocyte and 24 other tissues.
DR ExpressionAtlas; B6A8R8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0034987; F:immunoglobulin receptor binding; ISO:MGI.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:2000515; P:negative regulation of CD4-positive, alpha-beta T cell activation; ISO:MGI.
DR GO; GO:2000562; P:negative regulation of CD4-positive, alpha-beta T cell proliferation; IDA:UniProtKB.
DR GO; GO:1900017; P:positive regulation of cytokine production involved in inflammatory response; IDA:UniProtKB.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR Pfam; PF13895; Ig_2; 1.
DR SMART; SM00409; IG; 2.
DR SUPFAM; SSF48726; SSF48726; 2.
DR PROSITE; PS50835; IG_LIKE; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity; Cell membrane; Disulfide bond; Glycoprotein; Immunity;
KW Immunoglobulin domain; Innate immunity; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..16
FT /evidence="ECO:0000255"
FT CHAIN 17..288
FT /note="T-cell-interacting, activating receptor on myeloid
FT cells protein 1"
FT /id="PRO_0000394232"
FT TOPO_DOM 17..258
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 259..279
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 280..288
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DOMAIN 27..113
FT /note="Ig-like C2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DOMAIN 124..217
FT /note="Ig-like C2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 49..97
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 146..196
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 288 AA; 31392 MW; 6BD290E4856D0659 CRC64;
MISRLLSLLC LRLCVGQTDI PENGSPPKPS LSAWPSTVLP TKSHVTMQCK SPTPSKYFIL
KKEGFALNSV KPYNLTEETA DFHFTDLRQN DGGHYTCEYY SKWPHDTPSH PSNALFLLVT
GYLPQPSFQA HHRGTVTAGS KVTLQCQKAG SVLGPVKFAL LKVGHSTPVQ TRSSTGMVSD
FSLQNVTARD SGEYSCVYYQ AKAPYRASGP SNLLEISVID NHLPQDLAAS TFPPQLTATS
PKTPGTMTEG YTVDNLIRVG VAAAILLIVG GFLVEAWHSE RLSPNKPW
