TARSH_HUMAN
ID TARSH_HUMAN Reviewed; 1068 AA.
AC Q7Z7G0; B3KSL4; Q6ZW20; Q6ZW22; Q9C082; Q9UFI6;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Target of Nesh-SH3 {ECO:0000305};
DE Short=Tarsh;
DE AltName: Full=ABI gene family member 3-binding protein;
DE AltName: Full=Nesh-binding protein;
DE Short=NeshBP;
DE Flags: Precursor;
GN Name=ABI3BP {ECO:0000312|HGNC:HGNC:17265}; Synonyms=NESHBP, TARSH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), AND TISSUE SPECIFICITY.
RC TISSUE=Placenta;
RX PubMed=11501947; DOI=10.1007/s100380170049;
RA Matsuda S., Iriyama C., Yokozaki S., Ichigotani Y., Shirafuji N.,
RA Yamaki K., Hayakawa T., Hamaguchi M.;
RT "Cloning and sequencing of a novel human gene that encodes a putative
RT target protein of Nesh-SH3.";
RL J. Hum. Genet. 46:483-486(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3 AND 4).
RC TISSUE=Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 699-1068.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [7]
RP GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37.
RC TISSUE=Liver;
RX PubMed=19159218; DOI=10.1021/pr8008012;
RA Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.;
RT "Glycoproteomics analysis of human liver tissue by combination of multiple
RT enzyme digestion and hydrazide chemistry.";
RL J. Proteome Res. 8:651-661(2009).
RN [8]
RP VARIANT GLY-663.
RX PubMed=28493397; DOI=10.1002/humu.23246;
RG UK10K;
RA Rainger J., Williamson K.A., Soares D.C., Truch J., Kurian D.,
RA Gillessen-Kaesbach G., Seawright A., Prendergast J., Halachev M.,
RA Wheeler A., McTeir L., Gill A.C., van Heyningen V., Davey M.G.,
RA FitzPatrick D.R.;
RT "A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma.";
RL Hum. Mutat. 38:942-946(2017).
CC -!- SUBUNIT: Probably interacts with ABI3.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q7Z7G0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7Z7G0-2; Sequence=VSP_010860, VSP_010861;
CC Name=3;
CC IsoId=Q7Z7G0-3; Sequence=VSP_061186, VSP_010861;
CC Name=4;
CC IsoId=Q7Z7G0-4; Sequence=VSP_061187, VSP_010861;
CC -!- TISSUE SPECIFICITY: Expressed in brain, heart, lung, liver, pancreas
CC kidney and placenta. {ECO:0000269|PubMed:11501947}.
CC -!- DISEASE: Note=Defects in ABI3BP has been found in a patient with
CC isolated coloboma, a defect of the eye characterized by the absence of
CC ocular structures due to abnormal morphogenesis of the optic cup and
CC stalk, and the fusion of the fetal fissure (optic fissure). Isolated
CC colobomas may be associated with an abnormally small eye
CC (microphthalmia) or small cornea. {ECO:0000269|PubMed:28493397}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH30221.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB56034.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB056106; BAB32867.1; -; mRNA.
DR EMBL; AK093861; BAG52776.1; -; mRNA.
DR EMBL; AK123737; BAC85685.1; -; mRNA.
DR EMBL; AK123748; BAC85687.1; -; mRNA.
DR EMBL; AC068763; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC069223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC080014; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093009; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC106721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471052; EAW79811.1; -; Genomic_DNA.
DR EMBL; BC030221; AAH30221.1; ALT_INIT; mRNA.
DR EMBL; AL117664; CAB56034.1; ALT_INIT; mRNA.
DR CCDS; CCDS46880.1; -. [Q7Z7G0-1]
DR PIR; T17344; T17344.
DR RefSeq; NP_056244.2; NM_015429.3. [Q7Z7G0-1]
DR AlphaFoldDB; Q7Z7G0; -.
DR SMR; Q7Z7G0; -.
DR BioGRID; 117399; 9.
DR IntAct; Q7Z7G0; 7.
DR STRING; 9606.ENSP00000284322; -.
DR GlyConnect; 1785; 25 N-Linked glycans (6 sites).
DR GlyGen; Q7Z7G0; 6 sites, 24 N-linked glycans (6 sites).
DR iPTMnet; Q7Z7G0; -.
DR PhosphoSitePlus; Q7Z7G0; -.
DR BioMuta; ABI3BP; -.
DR DMDM; 50401533; -.
DR EPD; Q7Z7G0; -.
DR jPOST; Q7Z7G0; -.
DR MassIVE; Q7Z7G0; -.
DR MaxQB; Q7Z7G0; -.
DR PaxDb; Q7Z7G0; -.
DR PeptideAtlas; Q7Z7G0; -.
DR PRIDE; Q7Z7G0; -.
DR ProteomicsDB; 69533; -. [Q7Z7G0-1]
DR ProteomicsDB; 69534; -. [Q7Z7G0-2]
DR ProteomicsDB; 69535; -. [Q7Z7G0-3]
DR ProteomicsDB; 69536; -. [Q7Z7G0-4]
DR Antibodypedia; 32245; 230 antibodies from 26 providers.
DR DNASU; 25890; -.
DR Ensembl; ENST00000284322.10; ENSP00000284322.6; ENSG00000154175.18. [Q7Z7G0-1]
DR GeneID; 25890; -.
DR KEGG; hsa:25890; -.
DR UCSC; uc003dun.4; human. [Q7Z7G0-1]
DR CTD; 25890; -.
DR DisGeNET; 25890; -.
DR GeneCards; ABI3BP; -.
DR HGNC; HGNC:17265; ABI3BP.
DR HPA; ENSG00000154175; Low tissue specificity.
DR MIM; 606279; gene.
DR neXtProt; NX_Q7Z7G0; -.
DR OpenTargets; ENSG00000154175; -.
DR PharmGKB; PA134977769; -.
DR VEuPathDB; HostDB:ENSG00000154175; -.
DR eggNOG; ENOG502QRV7; Eukaryota.
DR GeneTree; ENSGT00530000063558; -.
DR HOGENOM; CLU_004059_0_0_1; -.
DR InParanoid; Q7Z7G0; -.
DR OrthoDB; 46073at2759; -.
DR PhylomeDB; Q7Z7G0; -.
DR TreeFam; TF331037; -.
DR PathwayCommons; Q7Z7G0; -.
DR SignaLink; Q7Z7G0; -.
DR BioGRID-ORCS; 25890; 11 hits in 1066 CRISPR screens.
DR ChiTaRS; ABI3BP; human.
DR GenomeRNAi; 25890; -.
DR Pharos; Q7Z7G0; Tbio.
DR PRO; PR:Q7Z7G0; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7Z7G0; protein.
DR Bgee; ENSG00000154175; Expressed in decidua and 170 other tissues.
DR ExpressionAtlas; Q7Z7G0; baseline and differential.
DR Genevisible; Q7Z7G0; HS.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR GO; GO:0005576; C:extracellular region; HDA:BHF-UCL.
DR GO; GO:0005615; C:extracellular space; HDA:BHF-UCL.
DR GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR GO; GO:0010811; P:positive regulation of cell-substrate adhesion; IBA:GO_Central.
DR CDD; cd00063; FN3; 2.
DR Gene3D; 2.60.40.10; -; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR Pfam; PF00041; fn3; 1.
DR SMART; SM00060; FN3; 2.
DR SUPFAM; SSF49265; SSF49265; 2.
DR PROSITE; PS50853; FN3; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Disease variant; Glycoprotein; Reference proteome;
KW Repeat; Secreted; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..1068
FT /note="Target of Nesh-SH3"
FT /id="PRO_0000022472"
FT DOMAIN 116..214
FT /note="Fibronectin type-III 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT DOMAIN 833..926
FT /note="Fibronectin type-III 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00316"
FT REGION 315..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 384..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..351
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..425
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..463
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..505
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 528..550
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 612..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 696..713
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 723..737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 37
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000269|PubMed:19159218"
FT VAR_SEQ 1..607
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:11501947,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_010860"
FT VAR_SEQ 1..524
FT /note="MLSSLGCLLLCGSITLALGNAQKLPKGKRPNLKVHINTTSDSILLKFLRPSP
FT NVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIVDAEPKYLIVVRPAPPPSQKKSCSGK
FT TRSRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKKWI
FT FQICPATETIVENLKPNTVYEFGVKDNVEGGIWSKIFNHKTVVGSKKVNGKIQSTYDQD
FT HTVPAYVPRKLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKLP
FT ASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSAL
FT DVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDR
FT ILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKR
FT RPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHTK
FT -> MTESLPVSDVLESVTLSTESPKETIAPAKTDYVYPTAKAPLWPEEPKTEVVESITY
FT VSEPPETTLETSPLPSQSITLPSPDEPQTE (in isoform 3)"
FT /id="VSP_061186"
FT VAR_SEQ 1..523
FT /note="MLSSLGCLLLCGSITLALGNAQKLPKGKRPNLKVHINTTSDSILLKFLRPSP
FT NVKLEGLLLGYGSNVSPNQYFPLPAEGKFTEAIVDAEPKYLIVVRPAPPPSQKKSCSGK
FT TRSRKPLQLVVGTLTPSSVFLSWGFLINPHHDWTLPSHCPNDRFYTIRYREKDKEKKWI
FT FQICPATETIVENLKPNTVYEFGVKDNVEGGIWSKIFNHKTVVGSKKVNGKIQSTYDQD
FT HTVPAYVPRKLIPITIIKQVIQNVTHKDSAKSPEKAPLGGVILVHLIIPGLNETTVKLP
FT ASLMFEISDALKTQLAKNETLALPAESKTPEVEKISARPTTVTPETVPRSTKPTTSSAL
FT DVSETTLASSEKPWIVPTAKISEDSKVLQPQTATYDVFSSPTTSDEPEISDSYTATSDR
FT ILDSIPPKTSRTLEQPRATLAPSETPFVPQKLEIFTSPEMQPTTPAPQQTTSIPSTPKR
FT RPRPKPPRTKPERTTSAGTITPKISKSPEPTWTTPAPGKTQFISLKPKIPLSPEVTHT
FT -> MTIVPTTDIEPVTVRTEATVTTLAPKTSQRTRTRRPRPKHKTTPRPETLQTKLDFG
FT PITPGTSSAPTTTTKRTRRPHPKPKTTPHPEVPQTKLAPKVPQRTHRPHPKPKTTLSPE
FT ELQTELVPVTDLGPVTFRTEIPATTLATKTSKRTRPPRPRPKTTPSPQAPETKPVPATV
FT LEPVTLRPEASTTLASKTSQRTRRPRLRTKTTPRPEAPES (in isoform 4)"
FT /id="VSP_061187"
FT VAR_SEQ 669
FT /note="P -> PVLNRTTTRPTRPKPSGMPSGNGVGT (in isoform 2,
FT isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:11501947,
FT ECO:0000303|PubMed:14702039"
FT /id="VSP_010861"
FT VARIANT 663
FT /note="D -> G (found in a patient with isolated coloboma;
FT unknown pathological significance)"
FT /evidence="ECO:0000269|PubMed:28493397"
FT /id="VAR_079855"
SQ SEQUENCE 1068 AA; 117895 MW; E37ABB9F1EBCC0C5 CRC64;
MLSSLGCLLL CGSITLALGN AQKLPKGKRP NLKVHINTTS DSILLKFLRP SPNVKLEGLL
LGYGSNVSPN QYFPLPAEGK FTEAIVDAEP KYLIVVRPAP PPSQKKSCSG KTRSRKPLQL
VVGTLTPSSV FLSWGFLINP HHDWTLPSHC PNDRFYTIRY REKDKEKKWI FQICPATETI
VENLKPNTVY EFGVKDNVEG GIWSKIFNHK TVVGSKKVNG KIQSTYDQDH TVPAYVPRKL
IPITIIKQVI QNVTHKDSAK SPEKAPLGGV ILVHLIIPGL NETTVKLPAS LMFEISDALK
TQLAKNETLA LPAESKTPEV EKISARPTTV TPETVPRSTK PTTSSALDVS ETTLASSEKP
WIVPTAKISE DSKVLQPQTA TYDVFSSPTT SDEPEISDSY TATSDRILDS IPPKTSRTLE
QPRATLAPSE TPFVPQKLEI FTSPEMQPTT PAPQQTTSIP STPKRRPRPK PPRTKPERTT
SAGTITPKIS KSPEPTWTTP APGKTQFISL KPKIPLSPEV THTKPAPKQT PRAPPKPKTS
PRPRIPQTQP VPKVPQRVTA KPKTSPSPEV SYTTPAPKDV LLPHKPYPEV SQSEPAPLET
RGIPFIPMIS PSPSQEELQT TLEETDQSTQ EPFTTKIPRT TELAKTTQAP HRFYTTVRPR
TSDKPHIRPG VKQAPRPSGA DRNVSVDSTH PTKKPGTRRP PLPPRPTHPR RKPLPPNNVT
GKPGSAGIIS SGPITTPPLR STPRPTGTPL ERIETDIKQP TVPASGEELE NITDFSSSPT
RETDPLGKPR FKGPHVRYIQ KPDNSPCSIT DSVKRFPKEE ATEGNATSPP QNPPTNLTVV
TVEGCPSFVI LDWEKPLNDT VTEYEVISRE NGSFSGKNKS IQMTNQTFST VENLKPNTSY
EFQVKPKNPL GEGPVSNTVA FSTESADPRV SEPVSAGRDA IWTERPFNSD SYSECKGKQY
VKRTWYKKFV GVQLCNSLRY KIYLSDSLTG KFYNIGDQRG HGEDHCQFVD SFLDGRTGQQ
LTSDQLPIKE GYFRAVRQEP VQFGEIGGHT QINYVQWYEC GTTIPGKW
