ID   TAS2_MAGO7              Reviewed;         771 AA.
AC   G4N134;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   14-DEC-2011, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Transcription factor TAS2 {ECO:0000303|PubMed:28820236};
DE   AltName: Full=Tenuazonic acid biosynthesis cluster protein 2 {ECO:0000303|PubMed:28820236};
GN   Name=TAS2 {ECO:0000303|PubMed:28820236}; ORFNames=MGG_07800;
OS   Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958) (Rice blast
OS   fungus) (Pyricularia oryzae).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Magnaporthales; Pyriculariaceae; Pyricularia.
OX   NCBI_TaxID=242507;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=70-15 / ATCC MYA-4617 / FGSC 8958;
RX   PubMed=15846337; DOI=10.1038/nature03449;
RA   Dean R.A., Talbot N.J., Ebbole D.J., Farman M.L., Mitchell T.K.,
RA   Orbach M.J., Thon M.R., Kulkarni R., Xu J.-R., Pan H., Read N.D.,
RA   Lee Y.-H., Carbone I., Brown D., Oh Y.Y., Donofrio N., Jeong J.S.,
RA   Soanes D.M., Djonovic S., Kolomiets E., Rehmeyer C., Li W., Harding M.,
RA   Kim S., Lebrun M.-H., Bohnert H., Coughlan S., Butler J., Calvo S.E.,
RA   Ma L.-J., Nicol R., Purcell S., Nusbaum C., Galagan J.E., Birren B.W.;
RT   "The genome sequence of the rice blast fungus Magnaporthe grisea.";
RL   Nature 434:980-986(2005).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=28820236; DOI=10.1021/acschembio.7b00353;
RA   Yun C.S., Motoyama T., Osada H.;
RT   "Regulatory mechanism of mycotoxin tenuazonic acid production in
RT   Pyricularia oryzae.";
RL   ACS Chem. Biol. 12:2270-2274(2017).
RN   [3]
RP   FUNCTION, AND INDUCTION.
RX   PubMed=32765467; DOI=10.3389/fmicb.2020.01641;
RA   Ninomiya A., Urayama S.I., Suo R., Itoi S., Fuji S.I., Moriyama H.,
RA   Hagiwara D.;
RT   "Mycovirus-induced tenuazonic acid production in a rice blast fungus
RT   Magnaporthe oryzae.";
RL   Front. Microbiol. 11:1641-1641(2020).
CC   -!- FUNCTION: Transcription factor; part of the gene cluster that mediates
CC       the biosynthesis of the toxin tenuazonic acid (TeA), an inhibitor of
CC       protein biosynthesis on ribosomes by suppressing the release of new
CC       protein (PubMed:28820236, PubMed:32765467). Directly regulates the
CC       expression of the hybrid PKS-NRPS synthetase TAS1 and the susequent
CC       production of TeA (PubMed:32765467). {ECO:0000269|PubMed:28820236,
CC       ECO:0000269|PubMed:32765467}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
CC   -!- INDUCTION: Expression is induced by the presence of dimethylsulphoxide
CC       (DMSO) or by the deletion of OSM1, a HOG1-related mitogen-activated
CC       protein kinase (PubMed:28820236). Expression is positively regulated by
CC       the secondary metabolism regulator LAE1 (PubMed:28820236). Infection by
CC       the totivirus induces the transcription of TAS2 (PubMed:32765467).
CC       {ECO:0000269|PubMed:28820236, ECO:0000269|PubMed:32765467}.
CC   -!- DISRUPTION PHENOTYPE: Impairs the ability to produce TeA under the
CC       DMSO-added, TeA-inducing culture conditions.
CC       {ECO:0000269|PubMed:28820236}.
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DR   EMBL; CM001233; EHA53210.1; -; Genomic_DNA.
DR   RefSeq; XP_003713017.1; XM_003712969.1.
DR   AlphaFoldDB; G4N134; -.
DR   EnsemblFungi; MGG_07800T0; MGG_07800T0; MGG_07800.
DR   GeneID; 2683727; -.
DR   KEGG; mgr:MGG_07800; -.
DR   VEuPathDB; FungiDB:MGG_07800; -.
DR   eggNOG; ENOG502SJ9D; Eukaryota.
DR   HOGENOM; CLU_013260_2_0_1; -.
DR   InParanoid; G4N134; -.
DR   OMA; RCSRQFP; -.
DR   OrthoDB; 1056082at2759; -.
DR   PHI-base; PHI:5606; -.
DR   Proteomes; UP000009058; Chromosome 3.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Virulence; Zinc.
FT   CHAIN           1..771
FT                   /note="Transcription factor TAS2"
FT                   /id="PRO_0000452834"
FT   DNA_BIND        54..80
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT   REGION          33..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          125..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   771 AA;  83821 MW;  DF82D245EB6AAC53 CRC64;
     MRQNSDYPSL GPFFFAGKIK LSIATESFSA MKRSRAESAS GPQQPSRRQP QTSCDLCRSR
     KIKCDRGTPC GNCRTRGLAC SIMSPSSAPS PGASSAESAG HGRLDTAILA RLAALEQAVF
     RSTSAVGGSG NAENGAHGDA TPRVPLSGLE REGRQTANFL DKAYDRCSSA STRSGYRPLD
     IRVAESCRDS FATGAPDPVW LMPQKDAVAM VHDFVENIYH LMPIVHIGST VSVIDNVYPA
     LQAGNINHVD PAQVALILGI CAACAFFWDG GVPCQHRFET EGEATSASLI WKTSALYAFE
     EAQRRGSRSL EGAQACAILA YLTYNMDGPS TRFYRLHTCS VTACRELGIH LVDSRGCEST
     DSTARRELKR RLWWHVAATD WMLGLNGGPL DGTYTVHPRQ ARVALPRNLN DSDLAIDSEI
     LTMPPHVPTQ ASCFLQVIRL AEICRMVVDS QSPDDSIADT AYNERVLASD ELFKKAIESM
     PPPLVLTSPI PEGAPRFLCL QRASLHLGFH SRRARLLRPF LLYKDSDGRQ GTTYRRSREL
     CVRSAQTVLE ISTSLLEHSL RIRSPEPFRR QILHHPGHHS CPASPIHRLG VVVNHLFCAC
     AILAFECSLR KNSSVHPRQQ HRGAGGEDDL DGMLVHAYRL LAAAGEECTV AADLVCAMRG
     VFAKYRVDGD LATVDGRGGQ NQIVGSSRSA MASVQTSAGG ACNEQQQIGP AAWPGMRGAI
     PDENQPMGEG SLETGKAWDG FDKDLDDLFV ANDTYCSWDQ IFARLGSYCG P