ID   TASL_BOVIN              Reviewed;         300 AA.
AC   Q32LD7;
DT   03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=TLR adapter interacting with SLC15A4 on the lysosome {ECO:0000250|UniProtKB:Q9HAI6};
GN   Name=TASL {ECO:0000250|UniProtKB:Q9HAI6};
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Crossbred X Angus; TISSUE=Liver;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Innate immune adapter that mediates the recruitment and
CC       activation of IRF5 downstream of endolysosomal toll-like receptors
CC       TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4
CC       downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5
CC       transcription factor via its pLxIS motif, leading to IRF5 activation
CC       and subsequent expression of type I interferons. Plays a role in the
CC       regulation of endolysosomal pH in immune cells such as B-cells,
CC       dendritic cells and monocytes. {ECO:0000250|UniProtKB:Q9HAI6}.
CC   -!- SUBUNIT: Interacts (via pLxIS motif) with IRF5; leading to IRF5
CC       activation. Interacts with SLC15A4; leading to its recruitment to
CC       endolysosome. {ECO:0000250|UniProtKB:Q9HAI6}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9HAI6}.
CC       Endosome membrane {ECO:0000250|UniProtKB:Q9HAI6}. Nucleus
CC       {ECO:0000250|UniProtKB:Q9HAI6}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9HAI6}. Note=Recruited to endolysosome
CC       following interaction with SLC15A4. May colocalize with TLR7 in the
CC       endosomal pathway. {ECO:0000250|UniProtKB:Q9HAI6}.
CC   -!- DOMAIN: The pLxIS motif constitutes an IRF5-binding motif: following
CC       phosphorylation, the phosphorylated pLxIS motif of TASL recruits IRF5.
CC       {ECO:0000250|UniProtKB:Q9HAI6}.
CC   -!- PTM: The phosphorylated pLxIS motif constitutes an IRF5-binding motif,
CC       leading to recruitment of the transcription factor IRF5 to induce type-
CC       I interferons and other cytokines. {ECO:0000250|UniProtKB:Q9HAI6}.
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DR   EMBL; BC109631; AAI09632.1; -; mRNA.
DR   RefSeq; NP_001033626.1; NM_001038537.2.
DR   AlphaFoldDB; Q32LD7; -.
DR   PaxDb; Q32LD7; -.
DR   PRIDE; Q32LD7; -.
DR   GeneID; 513911; -.
DR   KEGG; bta:513911; -.
DR   CTD; 80231; -.
DR   eggNOG; ENOG502QTA8; Eukaryota.
DR   OrthoDB; 980536at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0036020; C:endolysosome membrane; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0045089; P:positive regulation of innate immune response; ISS:UniProtKB.
DR   GO; GO:0034157; P:positive regulation of toll-like receptor 7 signaling pathway; ISS:UniProtKB.
DR   GO; GO:0034161; P:positive regulation of toll-like receptor 8 signaling pathway; ISS:UniProtKB.
DR   GO; GO:0035751; P:regulation of lysosomal lumen pH; ISS:UniProtKB.
DR   InterPro; IPR027869; TASL.
DR   PANTHER; PTHR14889; PTHR14889; 1.
DR   Pfam; PF15133; TASL; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Immunity; Innate immunity; Lysosome; Membrane;
KW   Nucleus; Phosphoprotein; Reference proteome.
FT   CHAIN           1..300
FT                   /note="TLR adapter interacting with SLC15A4 on the
FT                   lysosome"
FT                   /id="PRO_0000251251"
FT   MOTIF           289..293
FT                   /note="pLxIS motif"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HAI6"
FT   MOD_RES         293
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9HAI6"
SQ   SEQUENCE   300 AA;  33758 MW;  A282D28DC50EA2C7 CRC64;
     MLSEGYLSGL AYRNDIQWSY PSSNEQVAEE KEEEMEATAA ASLSYSSVDE TQVQNLYVSC
     KSSGKVISSV YSRESQHSRN PRITVLQTNP NPVYESPNLA AVELYRDTSR ETYLVPPSCK
     SICKNYNDLQ IAGGQVMAIN SATTDFPSEG SFQYGPLLKS SEIPLSMEDS MFTQPSDLPP
     TPIQRYSSYW RITSIKEKNS LQMQKPISNA VLNEYLEQKL VELYKQYFMD TGFHDSSPTQ
     ILASELIMTN VDQISIQVSI EKNLEISKAR DIVINRLLQY GSTEISTQSL HISQYSNVNP