TASL_MOUSE
ID TASL_MOUSE Reviewed; 298 AA.
AC Q9D3J9;
DT 03-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=TLR adapter interacting with SLC15A4 on the lysosome {ECO:0000250|UniProtKB:Q9HAI6};
GN Name=Tasl {ECO:0000250|UniProtKB:Q9HAI6};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Dendritic cell, and Head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Innate immune adapter that mediates the recruitment and
CC activation of IRF5 downstream of endolysosomal toll-like receptors
CC TLR7, TLR8 and TLR9. Following recruitment to endolysosome by SLC15A4
CC downstream of TLR7, TLR8 and TLR9, specifically recruits IRF5
CC transcription factor via its pLxIS motif, leading to IRF5 activation
CC and subsequent expression of type I interferons. Plays a role in the
CC regulation of endolysosomal pH in immune cells such as B-cells,
CC dendritic cells and monocytes. {ECO:0000250|UniProtKB:Q9HAI6}.
CC -!- SUBUNIT: Interacts (via pLxIS motif) with IRF5; leading to IRF5
CC activation. Interacts with SLC15A4; leading to its recruitment to
CC endolysosome. {ECO:0000250|UniProtKB:Q9HAI6}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q9HAI6}.
CC Endosome membrane {ECO:0000250|UniProtKB:Q9HAI6}. Nucleus
CC {ECO:0000250|UniProtKB:Q9HAI6}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9HAI6}. Note=Recruited to endolysosome
CC following interaction with SLC15A4. May colocalize with TLR7 in the
CC endosomal pathway. {ECO:0000250|UniProtKB:Q9HAI6}.
CC -!- DOMAIN: The pLxIS motif constitutes an IRF5-binding motif: following
CC phosphorylation, the phosphorylated pLxIS motif of TASL recruits IRF5.
CC {ECO:0000250|UniProtKB:Q9HAI6}.
CC -!- PTM: The phosphorylated pLxIS motif constitutes an IRF5-binding motif,
CC leading to recruitment of the transcription factor IRF5 to induce type-
CC I interferons and other cytokines. {ECO:0000250|UniProtKB:Q9HAI6}.
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DR EMBL; AK017351; BAB30703.1; -; mRNA.
DR EMBL; AK155591; BAE33338.1; -; mRNA.
DR EMBL; BC115577; AAI15578.1; -; mRNA.
DR CCDS; CCDS53127.1; -.
DR RefSeq; NP_001157011.1; NM_001163539.1.
DR RefSeq; XP_011245984.1; XM_011247682.2.
DR RefSeq; XP_017174109.1; XM_017318620.1.
DR AlphaFoldDB; Q9D3J9; -.
DR STRING; 10090.ENSMUSP00000109609; -.
DR iPTMnet; Q9D3J9; -.
DR PhosphoSitePlus; Q9D3J9; -.
DR MaxQB; Q9D3J9; -.
DR PaxDb; Q9D3J9; -.
DR PRIDE; Q9D3J9; -.
DR Antibodypedia; 379; 86 antibodies from 13 providers.
DR Ensembl; ENSMUST00000113976; ENSMUSP00000109609; ENSMUSG00000025058.
DR GeneID; 71398; -.
DR KEGG; mmu:71398; -.
DR UCSC; uc009trz.2; mouse.
DR CTD; 80231; -.
DR MGI; MGI:1918648; Tasl.
DR VEuPathDB; HostDB:ENSMUSG00000025058; -.
DR eggNOG; ENOG502QTA8; Eukaryota.
DR GeneTree; ENSGT00390000011425; -.
DR HOGENOM; CLU_081014_0_0_1; -.
DR InParanoid; Q9D3J9; -.
DR OMA; LAYWNDI; -.
DR OrthoDB; 980536at2759; -.
DR PhylomeDB; Q9D3J9; -.
DR TreeFam; TF335550; -.
DR BioGRID-ORCS; 71398; 2 hits in 70 CRISPR screens.
DR PRO; PR:Q9D3J9; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; Q9D3J9; protein.
DR Bgee; ENSMUSG00000025058; Expressed in granulocyte and 25 other tissues.
DR ExpressionAtlas; Q9D3J9; baseline and differential.
DR Genevisible; Q9D3J9; MM.
DR GO; GO:0036020; C:endolysosome membrane; ISS:UniProtKB.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0045089; P:positive regulation of innate immune response; ISS:UniProtKB.
DR GO; GO:0034157; P:positive regulation of toll-like receptor 7 signaling pathway; ISS:UniProtKB.
DR GO; GO:0034161; P:positive regulation of toll-like receptor 8 signaling pathway; ISS:UniProtKB.
DR GO; GO:0035751; P:regulation of lysosomal lumen pH; ISS:UniProtKB.
DR InterPro; IPR027869; TASL.
DR PANTHER; PTHR14889; PTHR14889; 1.
DR Pfam; PF15133; TASL; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endosome; Immunity; Innate immunity; Lysosome; Membrane;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..298
FT /note="TLR adapter interacting with SLC15A4 on the
FT lysosome"
FT /id="PRO_0000251253"
FT MOTIF 287..291
FT /note="pLxIS motif"
FT /evidence="ECO:0000250|UniProtKB:Q9HAI6"
FT MOD_RES 291
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9HAI6"
SQ SEQUENCE 298 AA; 33057 MW; 4D4E47B146022BFB CRC64;
MLSEGYLSGL TYWNDIHWNC ASYNEPVAGD QGKETSSVAA LSYSSVDETQ VQSLYVSCKS
SGKFISSVHA RASQHSRSQS RTVLQANSNP VFESPTLAAV GICRDVIRET YLVPPSCKSI
CKNYNDLHIA GGQVMAINSV MANFPSESSF EDGPLLKSSE ISLSMEDSTS TQLTELPLKP
IQRYSSYWRI TSIKEKSSLQ MQKPISNAVL NEYLEQKVVE LYKQYIMDTV FHDSSPTQIL
ASEFIMTNVD QISLQVSKEK NLDTSKVKDI VISHLLQLVS SEISTPSLHI SQYSNITP
