TASO2_HUMAN
ID TASO2_HUMAN Reviewed; 2430 AA.
AC Q5VWN6; Q2YD91; Q5VWN5; Q6ZRQ8; Q8IVG4; Q9BUZ7; Q9H5J9; Q9H7A4; Q9H996;
AC Q9NXA1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 140.
DE RecName: Full=Protein TASOR 2 {ECO:0000305};
GN Name=TASOR2 {ECO:0000312|HGNC:HGNC:23484};
GN Synonyms=C10orf18, FAM208B, KIAA2006;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 259-2430 (ISOFORM 2), AND
RP VARIANTS PRO-1075; ALA-1679 AND ASN-2404.
RC TISSUE=Brain;
RA Nagase T., Kikuno R., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 701-2430, AND VARIANTS ALA-1679
RP AND ASN-2404.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1662-2430, AND VARIANTS ALA-1679
RP AND ASN-2404.
RC TISSUE=Blood, and Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-384 AND SER-2037, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19413330; DOI=10.1021/ac9004309;
RA Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.;
RT "Lys-N and trypsin cover complementary parts of the phosphoproteome in a
RT refined SCX-based approach.";
RL Anal. Chem. 81:4493-4501(2009).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19; SER-1087 AND SER-2009,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [9]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [10]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-219; SER-685; SER-1087;
RP SER-1172; SER-1541; SER-1848; SER-2009; SER-2037 AND SER-2066, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [11]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1025, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [12]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-2007, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q5VWN6; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-745958, EBI-742909;
CC Q5VWN6; Q6PI77: BHLHB9; NbExp=3; IntAct=EBI-745958, EBI-11519926;
CC Q5VWN6; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-745958, EBI-8643161;
CC Q5VWN6; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-745958, EBI-11530605;
CC Q5VWN6; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-745958, EBI-749051;
CC Q5VWN6; P10606: COX5B; NbExp=4; IntAct=EBI-745958, EBI-1053725;
CC Q5VWN6; Q9UI47-2: CTNNA3; NbExp=3; IntAct=EBI-745958, EBI-11962928;
CC Q5VWN6; G5E9A7: DMWD; NbExp=3; IntAct=EBI-745958, EBI-10976677;
CC Q5VWN6; P84090: ERH; NbExp=6; IntAct=EBI-745958, EBI-711389;
CC Q5VWN6; P14136: GFAP; NbExp=3; IntAct=EBI-745958, EBI-744302;
CC Q5VWN6; Q86YR5-3: GPSM1; NbExp=3; IntAct=EBI-745958, EBI-10261098;
CC Q5VWN6; P28799: GRN; NbExp=3; IntAct=EBI-745958, EBI-747754;
CC Q5VWN6; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-745958, EBI-16429135;
CC Q5VWN6; O75031: HSF2BP; NbExp=3; IntAct=EBI-745958, EBI-7116203;
CC Q5VWN6; P04792: HSPB1; NbExp=3; IntAct=EBI-745958, EBI-352682;
CC Q5VWN6; O43464: HTRA2; NbExp=3; IntAct=EBI-745958, EBI-517086;
CC Q5VWN6; P42858: HTT; NbExp=12; IntAct=EBI-745958, EBI-466029;
CC Q5VWN6; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-745958, EBI-1055254;
CC Q5VWN6; Q7L273: KCTD9; NbExp=3; IntAct=EBI-745958, EBI-4397613;
CC Q5VWN6; O60333-2: KIF1B; NbExp=3; IntAct=EBI-745958, EBI-10975473;
CC Q5VWN6; Q9BVG8-5: KIFC3; NbExp=6; IntAct=EBI-745958, EBI-14069005;
CC Q5VWN6; Q2TBA0: KLHL40; NbExp=3; IntAct=EBI-745958, EBI-7851314;
CC Q5VWN6; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-745958, EBI-2341787;
CC Q5VWN6; Q99750: MDFI; NbExp=3; IntAct=EBI-745958, EBI-724076;
CC Q5VWN6; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-745958, EBI-16439278;
CC Q5VWN6; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-745958, EBI-10172526;
CC Q5VWN6; Q13064: MKRN3; NbExp=3; IntAct=EBI-745958, EBI-2340269;
CC Q5VWN6; P40692: MLH1; NbExp=6; IntAct=EBI-745958, EBI-744248;
CC Q5VWN6; P07196: NEFL; NbExp=3; IntAct=EBI-745958, EBI-475646;
CC Q5VWN6; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-745958, EBI-11750983;
CC Q5VWN6; Q8N7B6-2: PACRGL; NbExp=3; IntAct=EBI-745958, EBI-10694433;
CC Q5VWN6; Q8WWB5: PIH1D2; NbExp=5; IntAct=EBI-745958, EBI-10232538;
CC Q5VWN6; Q92569: PIK3R3; NbExp=5; IntAct=EBI-745958, EBI-79893;
CC Q5VWN6; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-745958, EBI-302345;
CC Q5VWN6; P31321: PRKAR1B; NbExp=3; IntAct=EBI-745958, EBI-2805516;
CC Q5VWN6; P60891: PRPS1; NbExp=3; IntAct=EBI-745958, EBI-749195;
CC Q5VWN6; P40937: RFC5; NbExp=3; IntAct=EBI-745958, EBI-712376;
CC Q5VWN6; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-745958, EBI-396669;
CC Q5VWN6; Q9UJW9: SERTAD3; NbExp=3; IntAct=EBI-745958, EBI-748621;
CC Q5VWN6; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-745958, EBI-5235340;
CC Q5VWN6; Q13148: TARDBP; NbExp=6; IntAct=EBI-745958, EBI-372899;
CC Q5VWN6; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-745958, EBI-10259086;
CC Q5VWN6; Q8WW01: TSEN15; NbExp=3; IntAct=EBI-745958, EBI-372432;
CC Q5VWN6; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-745958, EBI-739895;
CC Q5VWN6; P36508: ZNF76; NbExp=3; IntAct=EBI-745958, EBI-7254550;
CC Q5VWN6-2; Q8WXE1: ATRIP; NbExp=3; IntAct=EBI-10172380, EBI-747353;
CC Q5VWN6-2; Q9H257: CARD9; NbExp=3; IntAct=EBI-10172380, EBI-751319;
CC Q5VWN6-2; P84090: ERH; NbExp=3; IntAct=EBI-10172380, EBI-711389;
CC Q5VWN6-2; Q8TES7-6: FBF1; NbExp=3; IntAct=EBI-10172380, EBI-10244131;
CC Q5VWN6-2; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10172380, EBI-4397613;
CC Q5VWN6-2; O95751: LDOC1; NbExp=3; IntAct=EBI-10172380, EBI-740738;
CC Q5VWN6-2; P25800: LMO1; NbExp=3; IntAct=EBI-10172380, EBI-8639312;
CC Q5VWN6-2; Q6PF18: MORN3; NbExp=3; IntAct=EBI-10172380, EBI-9675802;
CC Q5VWN6-2; Q9HC98: NEK6; NbExp=3; IntAct=EBI-10172380, EBI-740364;
CC Q5VWN6-2; O15160: POLR1C; NbExp=3; IntAct=EBI-10172380, EBI-1055079;
CC Q5VWN6-2; Q96T49: PPP1R16B; NbExp=3; IntAct=EBI-10172380, EBI-10293968;
CC Q5VWN6-2; O43741: PRKAB2; NbExp=3; IntAct=EBI-10172380, EBI-1053424;
CC Q5VWN6-2; O15126: SCAMP1; NbExp=3; IntAct=EBI-10172380, EBI-954338;
CC Q5VWN6-2; P36406: TRIM23; NbExp=3; IntAct=EBI-10172380, EBI-740098;
CC Q5VWN6-2; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-10172380, EBI-5235829;
CC Q5VWN6-2; A8K5H9; NbExp=3; IntAct=EBI-10172380, EBI-10174421;
CC Q5VWN6-2; Q8N5D4; NbExp=3; IntAct=EBI-10172380, EBI-10266435;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5VWN6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5VWN6-2; Sequence=VSP_027733;
CC -!- SIMILARITY: Belongs to the TASOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA91115.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB14336.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB14993.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC87251.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL365356; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL596094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AB095927; BAC23103.1; -; mRNA.
DR EMBL; AK000367; BAA91115.1; ALT_INIT; mRNA.
DR EMBL; AK022966; BAB14336.1; ALT_INIT; mRNA.
DR EMBL; AK024762; BAB14993.1; ALT_INIT; mRNA.
DR EMBL; AK027014; BAB15627.1; -; mRNA.
DR EMBL; AK128051; BAC87251.1; ALT_INIT; mRNA.
DR EMBL; BC001759; AAH01759.2; -; mRNA.
DR EMBL; BC110339; AAI10340.1; -; mRNA.
DR CCDS; CCDS41485.1; -. [Q5VWN6-1]
DR RefSeq; NP_001308712.1; NM_001321783.1. [Q5VWN6-1]
DR RefSeq; NP_001308713.1; NM_001321784.1. [Q5VWN6-1]
DR RefSeq; NP_001308714.1; NM_001321785.1.
DR RefSeq; NP_060252.4; NM_017782.4. [Q5VWN6-1]
DR RefSeq; XP_005252532.1; XM_005252475.3. [Q5VWN6-1]
DR RefSeq; XP_005252537.1; XM_005252480.4. [Q5VWN6-1]
DR RefSeq; XP_005252538.1; XM_005252481.4. [Q5VWN6-1]
DR RefSeq; XP_005252539.1; XM_005252482.2. [Q5VWN6-1]
DR RefSeq; XP_011517827.1; XM_011519525.2. [Q5VWN6-1]
DR RefSeq; XP_016871852.1; XM_017016363.1. [Q5VWN6-1]
DR RefSeq; XP_016871854.1; XM_017016365.1. [Q5VWN6-1]
DR AlphaFoldDB; Q5VWN6; -.
DR BioGRID; 120252; 89.
DR IntAct; Q5VWN6; 83.
DR MINT; Q5VWN6; -.
DR STRING; 9606.ENSP00000328426; -.
DR GlyGen; Q5VWN6; 6 sites, 2 O-linked glycans (6 sites).
DR iPTMnet; Q5VWN6; -.
DR PhosphoSitePlus; Q5VWN6; -.
DR BioMuta; FAM208B; -.
DR DMDM; 74747424; -.
DR EPD; Q5VWN6; -.
DR jPOST; Q5VWN6; -.
DR MassIVE; Q5VWN6; -.
DR MaxQB; Q5VWN6; -.
DR PaxDb; Q5VWN6; -.
DR PeptideAtlas; Q5VWN6; -.
DR PRIDE; Q5VWN6; -.
DR ProteomicsDB; 65545; -. [Q5VWN6-1]
DR ProteomicsDB; 65546; -. [Q5VWN6-2]
DR Antibodypedia; 51208; 29 antibodies from 10 providers.
DR DNASU; 54906; -.
DR Ensembl; ENST00000328090.9; ENSP00000328426.5; ENSG00000108021.20. [Q5VWN6-1]
DR GeneID; 54906; -.
DR KEGG; hsa:54906; -.
DR UCSC; uc001iij.3; human. [Q5VWN6-1]
DR CTD; 54906; -.
DR DisGeNET; 54906; -.
DR GeneCards; TASOR2; -.
DR HGNC; HGNC:23484; TASOR2.
DR HPA; ENSG00000108021; Low tissue specificity.
DR neXtProt; NX_Q5VWN6; -.
DR OpenTargets; ENSG00000108021; -.
DR VEuPathDB; HostDB:ENSG00000108021; -.
DR eggNOG; ENOG502RJQA; Eukaryota.
DR GeneTree; ENSGT00530000063735; -.
DR HOGENOM; CLU_000681_0_0_1; -.
DR InParanoid; Q5VWN6; -.
DR OMA; VPCYIQI; -.
DR OrthoDB; 21269at2759; -.
DR PhylomeDB; Q5VWN6; -.
DR TreeFam; TF337844; -.
DR PathwayCommons; Q5VWN6; -.
DR SignaLink; Q5VWN6; -.
DR BioGRID-ORCS; 54906; 22 hits in 1092 CRISPR screens.
DR ChiTaRS; FAM208B; human.
DR GenomeRNAi; 54906; -.
DR Pharos; Q5VWN6; Tdark.
DR PRO; PR:Q5VWN6; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q5VWN6; protein.
DR Bgee; ENSG00000108021; Expressed in secondary oocyte and 204 other tissues.
DR ExpressionAtlas; Q5VWN6; baseline and differential.
DR Genevisible; Q5VWN6; HS.
DR GO; GO:0005829; C:cytosol; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR InterPro; IPR022168; DUF3699.
DR InterPro; IPR022188; DUF3715.
DR Pfam; PF12480; DUF3699; 1.
DR Pfam; PF12509; DUF3715; 2.
PE 1: Evidence at protein level;
KW Alternative splicing; Isopeptide bond; Phosphoprotein; Reference proteome;
KW Ubl conjugation.
FT CHAIN 1..2430
FT /note="Protein TASOR 2"
FT /id="PRO_0000299542"
FT REGION 416..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..648
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 704..727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1331..1360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1700..1727
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2046..2069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 433..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 464..488
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 713..727
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1710..1727
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2055..2069
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 384
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 685
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1025
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:24275569"
FT MOD_RES 1087
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 1172
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1541
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 1848
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 2009
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 2037
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:23186163"
FT MOD_RES 2062
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5DTT3"
FT MOD_RES 2066
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT CROSSLNK 2007
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 333..1137
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_027733"
FT VARIANT 499
FT /note="C -> G (in dbSNP:rs2254067)"
FT /id="VAR_050848"
FT VARIANT 630
FT /note="A -> D (in dbSNP:rs4748636)"
FT /id="VAR_050849"
FT VARIANT 724
FT /note="S -> Y (in dbSNP:rs56856085)"
FT /id="VAR_061601"
FT VARIANT 807
FT /note="I -> V (in dbSNP:rs45575338)"
FT /id="VAR_061602"
FT VARIANT 1075
FT /note="R -> P (in dbSNP:rs2797491)"
FT /evidence="ECO:0000269|Ref.2"
FT /id="VAR_034838"
FT VARIANT 1206
FT /note="V -> M (in dbSNP:rs3814196)"
FT /id="VAR_050850"
FT VARIANT 1578
FT /note="P -> S (in dbSNP:rs17143175)"
FT /id="VAR_050851"
FT VARIANT 1679
FT /note="V -> A (in dbSNP:rs2669142)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_034839"
FT VARIANT 1782
FT /note="T -> I (in dbSNP:rs11593253)"
FT /id="VAR_050852"
FT VARIANT 2288
FT /note="K -> R (in dbSNP:rs2275774)"
FT /id="VAR_050853"
FT VARIANT 2404
FT /note="S -> N (in dbSNP:rs2797501)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_034840"
FT CONFLICT 1885
FT /note="W -> R (in Ref. 3; BAA91115)"
FT /evidence="ECO:0000305"
FT CONFLICT 2043
FT /note="V -> A (in Ref. 3; BAA91115)"
FT /evidence="ECO:0000305"
FT CONFLICT 2065
FT /note="S -> I (in Ref. 3; BAA91115)"
FT /evidence="ECO:0000305"
FT CONFLICT 2359
FT /note="Q -> R (in Ref. 3; BAB14993)"
FT /evidence="ECO:0000305"
FT CONFLICT 2384
FT /note="A -> T (in Ref. 3; BAB14993)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2430 AA; 268843 MW; 8A6A94D318280DCE CRC64;
MAPPAHKSIL ERSENVLMSP WKGKLIVQDR MLCDIALWST YGAMIPTQLP QELDFKYVMK
VSSLKKRLPE AAFRKQNYLE EKVCFQDLCF NLYEVELSNR QGENIDKLTE CIKNKQLAII
KCLEDRGFFI LLTSSALLSE PDFGGKQMGL HGLHLFRSPL STGVKDLKVE DDISMKVIPI
LSTLNCALLE TKKSLPEERI HPNTLVKRHF QELYKADRSP SLSVAPQDRM KDPTFLGKLP
SGFDLIPPAE KCPSESLTQL NSYFSDPSAY ILEVSTALDL LAEHPQSPCV SDGICDAGFS
LVMTPDPEFL VSEAEVRKET ETKKDSEEML KAKKRVFPLS PASNLRVQPK RKASMPHMVQ
SKKVNLCRPF PKRTASRADN SSDSPTTLKL VKGQFPQKRK RGAEVLTAQF VQKTKLDRKN
QEAPISKDVP VPTNAKRARK QEKSPVKTVP RAKPPVKKSP QKQRVNIVKG NENPRNRKQL
QPVKGETASK LQSEISRGCQ EDGISINSVQ PENTTAAHND LPENSIVNYD SQALNMLADL
ALSSATSSTP VSEARNLHCS SELPQNDVLL SKENSLRGTS DHEYHRGVKT QKGELLPNPS
SDRKSNSGSD LTVSQDEESL VPCSQAPAKA QSALTEEMLE SSDASQSSSV SVEHSYALLL
TEHSKKHLQE REILSPLFPR NGTKSPEAAT PVGKVMPFRH QPGLLLQQKP PDDPVVKPKD
RPPSARVKKS SCSRIVLSCD DSVKITFKCE TEYAFSLDSK YTNNPLEKTV VRALHGPWNT
DLPDNVEEVK LLLHMWVALF YSNQNKIIRS SRKVVEHSNP AKYVSINSTL ESCELREIEE
SLGLEKCSAD SLLETNEISR AHAAEVSFRD PNCLLPFIKT PLTQGLELCV QNEQKKTFAR
ECDPDTQEDQ NFICSYNNEV TGEEAKQESL ETSNLVLSGI GSTQTNGPSV PSEEEIVQPL
DSTRVASYSG TVTQATFTRT YDGPGSQPVI CQSSVYGTLE NKVDILDAAV QTKTGTLQDL
IQHGSPINNE CHPSLERKDD NMGCAVINPE PITLTFEKNA HVPIQTEGVN TADERTTFKK
ELIKQVSPAA SLRHPVSTSE NARTQGLRDI PSLVVAGQKG TKYLCASSVG GETLDKAVCS
LQKETPLPVS LPSDKTMVME ALSLAKSSSH LSPSEEVRCT QDFLSQTQSL LGLSSEGLLE
LTQVEVDSSS ASTTLGRQCS LNCISSGCHT SGDSLELRKN HKNGPNTENM NLEAFDSVFI
KQTSLSVSRE VSLELSEEDS DIDLALTISP PTSPREEMPA GEIEQFEEAP FSNLELQDVA
EEIGEPEEVA LTESREVSSA DNVSVYPSVS EEPVENKERK GDNLQPVTLI LSKENCTLEI
AEEINVTSDF PFDSVIEEVS PASSPEPPVP VKETRPYQAV TPCILKLHGT QCEKSNQISQ
CESEDLGITE KENVFVGPTH PVGQDNFTQV QQMQVSAEMP LILTDHPGRT GRPTLPGKVT
EEIVSSEHDE GLSFSGKVQC YGRELNQPAS AAKCTGDFSP SPEKLVKSGN PLQPVSIENR
NLDLKHLVLE SSEPPFGPRN VIENKSLSDT LVSTTAPSGI VNVSVKQQTS PKSSQNHLFP
GDLKTDEGIY LQVKSLTAAS VDGAYSTQGC MCSVVPTLCS SSDNATLTHY VRPINAEPVF
QAQEIPAGRM ASLLKNGEPE AELHKETTGP GTAGPQSNTT SSLKGERKAI HTLQDVSTCE
TKELLNVGVS SLCAGPYQNT ADTKENLSKE PLASFVSESF DTSVCGIATE HVEIENSGEG
LRAEAGSETL GRDGEVGVNS DMHYELSGDS DLDLLGDCRN PRLDLEDSYT LRGSYTRKKD
VPTDGYESSL NFHNNNQEDW GCSSWVPGME TSLPPGHWTA AVKKEEKCVP PYVQIRDLHG
ILRTYANFSI TKELKDTMRT SHGLRRHPSF SANCGLPSSW TSTWQVADDL TQNTLDLEYL
RFAHKLKQTI KNGDSQHSAS SANVFPKESP TQISIGAFPS TKISEAPFLH PAPRSRSPLL
VTVVESDPRP QGQPRRGYTA SSLDSSSSWR ERCSHNRDLR NSQRNHTVSF HLNKLKYNST
VKESRNDISL ILNEYAEFNK VMKNSNQFIF QDKELNDVSG EATAQEMYLP FPGRSASYED
IIIDVCTNLH VKLRSVVKEA CKSTFLFYLV ETEDKSFFVR TKNLLRKGGH TEIEPQHFCQ
AFHRENDTLI IIIRNEDISS HLHQIPSLLK LKHFPSVIFA GVDSPGDVLD HTYQELFRAG
GFVISDDKIL EAVTLVQLKE IIKILEKLNG NGRWKWLLHY RENKKLKEDE RVDSTAHKKN
IMLKSFQSAN IIELLHYHQC DSRSSTKAEI LKCLLNLQIQ HIDARFAVLL TDKPTIPREV
FENSGILVTD VNNFIENIEK IAAPFRSSYW
