TASO2_MOUSE
ID TASO2_MOUSE Reviewed; 2382 AA.
AC Q5DTT3; O35330; Q0P5P9; Q3UUS0; Q5U5L9; Q6DI89; Q6ZQM5; Q91W76;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-SEP-2007, sequence version 2.
DT 03-AUG-2022, entry version 105.
DE RecName: Full=Protein TASOR 2 {ECO:0000305};
DE AltName: Full=Peripheral benzodiazepine receptor-associated protein 20;
GN Name=Tasor2;
GN Synonyms=Fam208b {ECO:0000312|MGI:MGI:2145274}, Kiaa2006, Pap20;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic intestine;
RA Okazaki N., Kikuno R.F., Ohara R., Inamoto S., Nagase T., Ohara O.,
RA Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene. The
RT complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by
RT screening of terminal sequences of cDNA clones randomly sampled from size-
RT fractionated libraries.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and FVB/N; TISSUE=Brain, Colon, Eye, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-413 AND 1376-2382.
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 393-582.
RC STRAIN=BALB/cJ;
RX PubMed=11731621; DOI=10.1210/mend.15.12.0736;
RA Li H., Degenhardt B., Tobin D., Yao Z.-X., Tasken K., Papadopoulos V.;
RT "Identification, localization, and function in steroidogenesis of PAP7: a
RT peripheral-type benzodiazepine receptor- and PKA (RIalpha)-associated
RT protein.";
RL Mol. Endocrinol. 15:2211-2228(2001).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1430; SER-1540; SER-1990;
RP SER-2012 AND SER-2015, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE
RP ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the TASOR family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB71190.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH16423.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH75685.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAC87659.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD90477.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK220437; BAD90477.1; ALT_INIT; mRNA.
DR EMBL; BC016423; AAH16423.1; ALT_INIT; mRNA.
DR EMBL; BC045617; AAH45617.1; -; mRNA.
DR EMBL; BC075685; AAH75685.1; ALT_SEQ; mRNA.
DR EMBL; BC085160; AAH85160.1; -; mRNA.
DR EMBL; AK128934; BAC87659.1; ALT_INIT; mRNA.
DR EMBL; AK138119; BAE23554.1; -; mRNA.
DR EMBL; AF020338; AAB71190.1; ALT_INIT; mRNA.
DR CCDS; CCDS49201.1; -.
DR RefSeq; NP_598824.3; NM_134063.3.
DR RefSeq; XP_006516523.1; XM_006516460.3.
DR RefSeq; XP_006516524.1; XM_006516461.3.
DR AlphaFoldDB; Q5DTT3; -.
DR BioGRID; 222786; 3.
DR IntAct; Q5DTT3; 3.
DR MINT; Q5DTT3; -.
DR STRING; 10090.ENSMUSP00000093774; -.
DR iPTMnet; Q5DTT3; -.
DR PhosphoSitePlus; Q5DTT3; -.
DR EPD; Q5DTT3; -.
DR jPOST; Q5DTT3; -.
DR MaxQB; Q5DTT3; -.
DR PaxDb; Q5DTT3; -.
DR PeptideAtlas; Q5DTT3; -.
DR PRIDE; Q5DTT3; -.
DR ProteomicsDB; 277020; -.
DR Antibodypedia; 51208; 29 antibodies from 10 providers.
DR DNASU; 105203; -.
DR Ensembl; ENSMUST00000096069; ENSMUSP00000093774; ENSMUSG00000033799.
DR GeneID; 105203; -.
DR KEGG; mmu:105203; -.
DR UCSC; uc007piw.1; mouse.
DR CTD; 54906; -.
DR MGI; MGI:2145274; Tasor2.
DR VEuPathDB; HostDB:ENSMUSG00000033799; -.
DR eggNOG; ENOG502RJQA; Eukaryota.
DR GeneTree; ENSGT00530000063735; -.
DR HOGENOM; CLU_000681_0_0_1; -.
DR InParanoid; Q5DTT3; -.
DR OMA; VPCYIQI; -.
DR OrthoDB; 21269at2759; -.
DR PhylomeDB; Q5DTT3; -.
DR TreeFam; TF337844; -.
DR BioGRID-ORCS; 105203; 2 hits in 71 CRISPR screens.
DR ChiTaRS; Fam208b; mouse.
DR PRO; PR:Q5DTT3; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q5DTT3; protein.
DR Bgee; ENSMUSG00000033799; Expressed in spermatid and 249 other tissues.
DR ExpressionAtlas; Q5DTT3; baseline and differential.
DR Genevisible; Q5DTT3; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR InterPro; IPR022168; DUF3699.
DR InterPro; IPR022188; DUF3715.
DR Pfam; PF12480; DUF3699; 1.
DR Pfam; PF12509; DUF3715; 1.
PE 1: Evidence at protein level;
KW Isopeptide bond; Phosphoprotein; Reference proteome; Ubl conjugation.
FT CHAIN 1..2382
FT /note="Protein TASOR 2"
FT /id="PRO_0000299543"
FT REGION 320..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..478
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..639
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1301..1324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1949..1987
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2000..2021
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..384
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 454..468
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1950..1983
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT MOD_RES 219
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT MOD_RES 1021
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT MOD_RES 1082
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT MOD_RES 1430
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1540
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1962
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT MOD_RES 1990
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2012
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2015
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 2019
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT CROSSLNK 1960
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q5VWN6"
FT CONFLICT 413
FT /note="L -> P (in Ref. 3; BAE23554)"
FT /evidence="ECO:0000305"
FT CONFLICT 449
FT /note="P -> S (in Ref. 4; AAB71190)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2382 AA; 264278 MW; C903BC7139AAA200 CRC64;
MAAPTSKIIL ELNKNALISP WKGQFIIQGC LLCDITLWST YGTVVPLQLP RELDFKYVMD
VSSLKESLPE AAFRRRSYLE QKVCCQDLCF DLYEVELTNK QGENIDKLME YVKNKELALI
KCLEDKSFFI LFTSSALTPE PGFGAEQMGL HGLHLFHAPQ TAGAKDLKVE DGISLKVIPI
LPALSYALLE AKKSLSEEGI PPNILVKHSF QELYKVDKSL SLMAPPQDGV EDTASTGKLS
HAFDLPPPLE TCPSESLTHL KCYFSDPAGY TLDLSAALDL LAEHPQFPCI ADGVCDAGFS
LVMTPDPEFL DSEMEIRKTE TAEKSGRKLK VKKKAVTPSS NQRVQPKRKA STTAVTLPSK
RVSLGRPTSK RTVPRTDNRS CNPTLKLVKG QFPQKRKRGA EVLAAQIVQK TRLERKKQEA
SVSKDAPVPT NTKRAKKQEK SPGRIASQPK PPMKKSPQKR KVNVARGRRN TRKQLQPAEK
EIALHLQSEI SSDGQKDGLN LSTSQQESIS MIPKGPPENS VISCDSQALN MLADLALSSA
AASIPSCKPR NLPCVSDLPR NNVLLTKENP LLGASDHEYH KGVKSQKAVL LPKPYSDEKI
SSESDLTRSQ EENLVPCAQP LPIAQPAPHS EARELSDASQ NSVVVEHSYA LLLAEQSQKH
LHQRKLPSPA FVKNGIKGPE AGTPVGKVMP FRHLQNTSPL QKHSEDSLMK HKSLFVSSTL
KEFFCSHTVL KCDGSFKITF KCEGEYVFSL DSKYTSNPLE KTVLRALHGP WNTDLPENVD
DVKLLLHIWV ALFYSKNNKV IGSPRKVVEH KNPAKYVCIN RSLESLDHSE IEAFSNVERP
SVEGSVDPLL ETKETHIGHA TNMTFPGPNR VLPFINPPTT RDLELCVQND QKEVFTGECH
LDTSGNQNFI YSCNTEVTGG KTKQELSNKL ETSNVVLSGV VSAQSHGTCI PSEDKTCQST
KMVSYNDSVT QATLTTAYDE ASSELMCQKS VFDNLENKVD SFHPSPLIKT DAVQDVIQHS
SHINNECQPS VEKREDNVEC MMVNLDPVTL AFEKNASVPI HTEVHTTDKP TGFNIELVKR
VSPASSVQYP MSALEEVQTQ SSRDVPSLAM SEYKDSKCLS ASSVKKETPP ESLCLLQKEI
PPLTSSADEG LIMEALSLVK SSSYSLASDK TKCPQDDSLQ TQNGLSMSLD EVLEPSKVNV
VSSTSVTLRE QPSPNCIPAM SDVAGASTVI MNSGSSSLNQ EKILQTFSLV FPKQTDLSLK
REEVSMELSG EEADINLTLT ISPPTSPSEE IAAGEIEQFQ KTPVSNVGQQ SRSEEMVEPE
EEERLIRNRE INSASCMSVY PVESRELLKN CTPEVTEKVN VTLDFPFGPL IEVSPASSPD
PIVQPGDRPS SPCCLKLHSS QSEKTNKFSQ IKSGEVTIPE KESLFLGPES PKGQDKLAEV
QVQISAEMLQ ITTNAEVEGR VNMPGKVTKV SVPSEHSENL SFLEKVQCNT ELNELSLPAK
YGGNFKPLEK SGNSLEAGCM ENRNVDVKHL ALESSVPSCS PRKVVENKSL TDTLVSITTS
GIVNMSLKQT SSKNIKKNVC DSDVKTDSDV KTEADSNMQT EAVNSALIDK TDVQAYSHPE
VSKFVSSSDS AQCTYHAKPV SVEPGFQTQE IPVVRMASLL KNIGVELHEE KMDLSATGLQ
SNSMSAKDEQ KTMHVLQDTI CEVKEFLNGD VFSQNAHSCQ NTVDFSKSIS EEPSASFVPE
FVDAICGVYK EHTFNESPNM VHETKADAET LSRNTEISVN ASMFCGPRSG AYVQDSHDCK
SCKFDVENLR GNHESQKDAV KDSCDSFTSL NNSDDTWACS SKISTLETHI PPRDQETEPR
LISPNKCIPR YIQIPDSHGI PKTYANFTIT KEFKDTTRRL HSLKRHRNLS ANCNLLSSWT
STWHVTDDLT QHTLDLEYLR FDHKLKQIKK GGSQQSSFPK ESLVQISSGT SPSTQTSEAS
GLHLPPESRS PILVTVVRAD TRQQSHHRRG CSPSSLDGSS SFWKKKCSQS RNLKNSERSQ
TVPFHLNKLK YNSTLKESRN DISLILNEYA EFNKIMMNSK QIVSQDEELN VASAEAVFQE
AYQPRQPVSY EDVITDLCAT LHVKLKGVVR EACKSPFWFY LVETEDKSFL LRTKSILKKG
GHIEIELLDF CQAFHRENET LLVIIKNEDI ISHLHQIPSL LKLKHFPSVV FAGVDSPEDI
VNETYQELFR SGGFVVSDDV ILESLTLVQL KEILKILEKL NENGKWKWLL HYRESKNLKE
DVRVDSIAHK KNLILKSYQS VNIIDLLHYH NCDSPSSTKA EIFKCLLNLQ IQHISARFAV
FLTDKPTVST EIFENNGILV TDVNYFTENI QKIAAPFRSS YW
