ID   TASOR_XENLA             Reviewed;        1555 AA.
AC   Q2T9I9; Q4V7I6;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=Protein TASOR {ECO:0000305};
DE   AltName: Full=Transgene activation suppressor protein {ECO:0000250|UniProtKB:Q9UK61};
GN   Name=tasor {ECO:0000250|UniProtKB:Q9UK61}; Synonyms=fam208a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg, and Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the HUSH complex, a multiprotein complex that
CC       mediates epigenetic repression. The HUSH complex is recruited to
CC       genomic loci rich in H3K9me3 and is probably required to maintain
CC       transcriptional silencing by promoting further deposition of H3K9me3.
CC       {ECO:0000250|UniProtKB:Q9UK61}.
CC   -!- SUBUNIT: Component of the HUSH complex. {ECO:0000250|UniProtKB:Q9UK61}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9UK61}.
CC       Chromosome {ECO:0000250|UniProtKB:Q9UK61}. Note=Localizes to chromatin.
CC       {ECO:0000250|UniProtKB:Q9UK61}.
CC   -!- SIMILARITY: Belongs to the TASOR family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH97889.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
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DR   EMBL; BC097889; AAH97889.1; ALT_SEQ; mRNA.
DR   EMBL; BC111503; AAI11504.1; -; mRNA.
DR   RefSeq; NP_001089959.1; NM_001096490.1.
DR   AlphaFoldDB; Q2T9I9; -.
DR   SMR; Q2T9I9; -.
DR   MaxQB; Q2T9I9; -.
DR   PRIDE; Q2T9I9; -.
DR   GeneID; 735029; -.
DR   KEGG; xla:735029; -.
DR   CTD; 735029; -.
DR   Xenbase; XB-GENE-5961190; tasor.S.
DR   OrthoDB; 57214at2759; -.
DR   Proteomes; UP000186698; Chromosome 4S.
DR   Bgee; 735029; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR022188; DUF3715.
DR   Pfam; PF12509; DUF3715; 1.
PE   2: Evidence at transcript level;
KW   Chromosome; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..1555
FT                   /note="Protein TASOR"
FT                   /id="PRO_0000295730"
FT   REGION          1..74
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          645..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          744..773
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          870..911
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1390..1462
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..51
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        648..688
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        689..711
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        744..758
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        873..908
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1399..1418
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1426..1462
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        54
FT                   /note="P -> L (in Ref. 1; AAH97889)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1555 AA;  176403 MW;  71774880763A6822 CRC64;
     MEENKSVAEG KAATGSLKES EETSAQNGEL GEPEVQQTLK RTNSTESGGT GQKPPEEAPR
     RRFQIPRKSR DKRALQVISS GSREFEEILK ILHSSYLDAN SKASFSYKCA RLVHNEFLEK
     EFTEKRRQLK FDGRLDKELV ESYVFLLVDQ EQMHSITEKG LHVGHSRMTT LGKPSMGVYL
     SRYADLLQAN PLETGTTGDI FIFKVIKGKM KFVFDHIRNN QMDSFSGNGG LDPVPKHECH
     VLKNMNAVTA LLGYRAFERT QYYFYEYGFD EVLKRPRHVC PYAVMSFGYK DELATRQPPL
     PTSGPVSFPT ERSFDRSSFT LWRGQLLNKG KLLCYASLKS TSGPFIPYRL PERLDLDIVI
     KIEVIKKSIP AVLFYKETHN KPNEAKHGGI YSRLYEVVEK TRTGSHLQGL LQKIERENLA
     LVKPLDDRGF MFLYFPSPMT SAYASAKTRL LHALFIYHES RLTQPVANVP VPPSFVPESH
     EFMPEVLTFV PALHFALHKS QSDTSADFND VVEKHSRIYL KRRAEKLNKF KEYVLKPYDS
     RLDYKKSLYV APRIKGHIES ALRSYLFGSE AYTIPVDKAK EMLKENQRFQ QFSPVSDYEP
     VEDDHDSNKY NKKCPVSYVE TNSEKSSEST DWDIDKINGL INLIQKKKQS KPETDEPSGV
     GLKRKLDRQS EKAWKHRKCE ENVHHDNEPG ESAQSLISSL GGQDTDLRQE TESLSSECIK
     MLLEKLADSC IDPAMAESLK TLKQNSTEEL PSQKLKNLSQ AHDTEREGAG QDQHIVYNDQ
     TTDNQENTTC LSEEAQQAEG SHSDHSVLME EKILDPPLES ASPCPSNTAG NNCPAQGPNS
     LDLEMHWKLI PIAEANLTEE QLVYVSTEDA LPNDPRAGHK RRGSRYSPLH ETERQRPRHD
     RDYCRSLTTP SRTERNMLQS KHCHNGLIEN TVLEVYNTFS EQLHDVLKQR DVPYMVPAAP
     PLLSSDDRVL KLSDCLCEQV SDICVQQYVD DLHTTLDSVV AAHINSCAVS RTGSPVTEIM
     AATEVHTFHP KQTVTEYPHV HEHFHVNDLH SDVREANPFS ADHVYKVGEE NAANGHALSH
     NSRDLSQETP EISTSGVTDL SEPHLAISNL INQMNPEVFN NLVKIITHVN KNSVKFYVHT
     EEENAICQNI KEYLLKLGNT ECRPEKFLES KTKADKLLII IQNEDIPNCI HRVPALVLLK
     RLPSVSFAGV DSLDDLKNHT YNEIFVSGGF IVSDESVLNP ETVTIDELKK FLMFLEEINS
     PDANWQWKIH YKFHKRLKEL GRLNTNALNI LTLLTTYQKK NLVEILSYHL SCDPQNQQAP
     QLECLIKLQV QYMKQRHVLF LTEKDAARFP DYCDNGIVVT RMVDFMDNFS NLIGHHSPNN
     EEQRLSQLTN QGDETAPGEA DSKEEEDMSL DSEDDTPPIE VCTDSWKPES QKQNISSLLE
     LVDKDQTESP STLNQGKTPT LDELQPITPV SVAGSTTGEN SVSTGDELGS NTKDYNREVN
     LSHQFSHFSL LTHQTFLGSM YPTLTNPSQA EICFMNSYSQ LTEPETSKNS ERKQK