TASR_HAPIR
ID TASR_HAPIR Reviewed; 566 AA.
AC A0A0F7GH49;
DT 29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2015, sequence version 1.
DT 03-AUG-2022, entry version 22.
DE RecName: Full=Transcription factor tasR {ECO:0000303|PubMed:25885659};
DE AltName: Full=Tetramic acid Sch210971/2 biosynthesis cluster protein R {ECO:0000303|PubMed:25885659};
GN Name=tasR {ECO:0000303|PubMed:25885659};
OS Hapsidospora irregularis.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreales incertae sedis; Hapsidospora.
OX NCBI_TaxID=95324;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, CATALYTIC ACTIVITY, AND
RP PATHWAY.
RX PubMed=25885659; DOI=10.1021/acs.orglett.5b00715;
RA Kakule T.B., Zhang S., Zhan J., Schmidt E.W.;
RT "Biosynthesis of the tetramic acids Sch210971 and Sch210972.";
RL Org. Lett. 17:2295-2297(2015).
CC -!- FUNCTION: Transcription factor that regulates the expression of the
CC gene cluster that mediates the biosynthesis of the tetramic acids
CC Sch210971 and Sch210972, potential anti-HIV fungal natural product that
CC contain a decalin core. {ECO:0000305|PubMed:25885659}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR EMBL; KP835202; AKG54859.1; -; Genomic_DNA.
DR SMR; A0A0F7GH49; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd00067; GAL4; 1.
DR Gene3D; 4.10.240.10; -; 1.
DR InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR Pfam; PF00172; Zn_clus; 1.
DR SMART; SM00066; GAL4; 1.
DR SUPFAM; SSF57701; SSF57701; 1.
DR PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Transcription;
KW Transcription regulation; Zinc.
FT CHAIN 1..566
FT /note="Transcription factor tasR"
FT /id="PRO_0000453351"
FT DNA_BIND 35..68
FT /note="Zn(2)-C6 fungal-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 72..174
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 346..382
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 422..453
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 74..89
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 97..113
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 566 AA; 57025 MW; BAB78E98162906BD CRC64;
MISASRMEES ASSSSLSDAA APPPGAALQS IRSSCDRCRF HKLKCNVPAA GHGGPVPCER
CTRAKVPCVF GRRRRANRPS EDKKRPAAPT RRATMPSPSP TPASTSAAHG GGDSATTGSA
DPPPPPPSTM DAALQRTPAS HSDTGPAATY DGRSWETLMT GGLGDSPDIL PGQHNSAGNG
WEWFHQGFGL DDTSMFDADT LDPAIIWSPP TPQHIPTAAL ALATTELDMT TAPPATSGGT
ANMMRSSNTN TNSNSNSSSC WAPVQQLLPL IADMQQRLKM LEQGPWQGGD FPQSLDDYPV
GAVLHLSREF GSIAGQVLSR AIAAGMVTGG GVPPVVRNHA TDGGREFIVT NNPQKHLGSE
SSSSSSSSIS NSSSNNEAGG DDGGVDTATA LLVLGGYMWL MRIYGAALGH FQVHLSGLSG
ASESDGCGRG ASRSGPNASP ALRLGELPST GTAPDLGRIH TALGMLQGAL AEVEGQLGRG
GAVARNLVVA LLTRQEAVSR GVGGGGGGGG GGGGGGGGGV GGGGGGGGGP GGSSEHSGGS
SDVDDCEGLG GKVQSVKELL REKMGF
