ID   TAS_SHIFL               Reviewed;         346 AA.
AC   P0A9T5; Q46933;
DT   19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Protein tas;
GN   Name=tas; OrderedLocusNames=SF2844, S3042;
OS   Shigella flexneri.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=623;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=301 / Serotype 2a;
RX   PubMed=12384590; DOI=10.1093/nar/gkf566;
RA   Jin Q., Yuan Z., Xu J., Wang Y., Shen Y., Lu W., Wang J., Liu H., Yang J.,
RA   Yang F., Zhang X., Zhang J., Yang G., Wu H., Qu D., Dong J., Sun L.,
RA   Xue Y., Zhao A., Gao Y., Zhu J., Kan B., Ding K., Chen S., Cheng H.,
RA   Yao Z., He B., Chen R., Ma D., Qiang B., Wen Y., Hou Y., Yu J.;
RT   "Genome sequence of Shigella flexneri 2a: insights into pathogenicity
RT   through comparison with genomes of Escherichia coli K12 and O157.";
RL   Nucleic Acids Res. 30:4432-4441(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700930 / 2457T / Serotype 2a;
RX   PubMed=12704152; DOI=10.1128/iai.71.5.2775-2786.2003;
RA   Wei J., Goldberg M.B., Burland V., Venkatesan M.M., Deng W., Fournier G.,
RA   Mayhew G.F., Plunkett G. III, Rose D.J., Darling A., Mau B., Perna N.T.,
RA   Payne S.M., Runyen-Janecky L.J., Zhou S., Schwartz D.C., Blattner F.R.;
RT   "Complete genome sequence and comparative genomics of Shigella flexneri
RT   serotype 2a strain 2457T.";
RL   Infect. Immun. 71:2775-2786(2003).
CC   -!- SIMILARITY: Belongs to the aldo/keto reductase family. Aldo/keto
CC       reductase 2 subfamily. {ECO:0000305}.
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DR   EMBL; AE005674; AAN44330.1; -; Genomic_DNA.
DR   EMBL; AE014073; AAP18156.1; -; Genomic_DNA.
DR   RefSeq; NP_708623.1; NC_004337.2.
DR   RefSeq; WP_001199295.1; NZ_WPGW01000008.1.
DR   AlphaFoldDB; P0A9T5; -.
DR   SMR; P0A9T5; -.
DR   STRING; 198214.SF2844; -.
DR   EnsemblBacteria; AAN44330; AAN44330; SF2844.
DR   EnsemblBacteria; AAP18156; AAP18156; S3042.
DR   GeneID; 1025802; -.
DR   GeneID; 66673299; -.
DR   KEGG; sfl:SF2844; -.
DR   KEGG; sfx:S3042; -.
DR   PATRIC; fig|198214.7.peg.3384; -.
DR   HOGENOM; CLU_023205_2_0_6; -.
DR   OMA; PPYSLFW; -.
DR   OrthoDB; 1351747at2; -.
DR   Proteomes; UP000001006; Chromosome.
DR   Proteomes; UP000002673; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.100; -; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   Pfam; PF00248; Aldo_ket_red; 1.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; SSF51430; 1.
PE   3: Inferred from homology;
KW   NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..346
FT                   /note="Protein tas"
FT                   /id="PRO_0000070387"
FT   ACT_SITE        53
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000250"
FT   BINDING         234..244
FT                   /ligand="NADP(+)"
FT                   /ligand_id="ChEBI:CHEBI:58349"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   346 AA;  38500 MW;  111692D06CA07CD7 CRC64;
     MQYHRIPHSS LEVSTLGLGT MTFGEQNSEA DAHAQLDYAV AQGINLIDVA EMYPVPPRPE
     TQGLTETYVG NWLAKHGSRE KLIIASKVSG PSRNNDKGIR PDQALDRKNI REALHDSLKR
     LQTDYLDLYQ VHWPQRPTNC FGKLGYSWTD SAPAVSLLDT LDALAEYQRA GKIRYIGVSN
     ETAFGVMRYL HLADKHDLPR IVTIQNPYSL LNRSFEVGLA EVSQYEGVEL LAYSCLGFGT
     LTGKYLNGAK PAGARNTLFS RFTRYSGEQT QKAVAAYVDI ARRHGLDPAQ MALAFVRRQP
     FVASTLLGAT TMDQLKTNIE SLHLELSEDV LAEIEAVHQV YTYPAP