ID   BPTA_BORBN              Reviewed;         206 AA.
AC   E4QH55; O50712; Q56NH3; Q56NH4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   08-FEB-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Protein BptA;
DE   AltName: Full=Borrelial persistence in ticks protein A;
DE   Flags: Precursor;
GN   Name=bptA; OrderedLocusNames=BbuN40_E05;
OS   Borreliella burgdorferi (strain N40) (Borrelia burgdorferi).
OG   Plasmid lp25, and Plasmid N40_lp25.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=521007;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=N40; PLASMID=lp25;
RX   PubMed=15860579; DOI=10.1073/pnas.0502565102;
RA   Revel A.T., Blevins J.S., Almazan C., Neil L., Kocan K.M., de la Fuente J.,
RA   Hagman K.E., Norgard M.V.;
RT   "bptA (bbe16) is essential for the persistence of the Lyme disease
RT   spirochete, Borrelia burgdorferi, in its natural tick vector.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:6972-6977(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N40; PLASMID=N40_lp25;
RX   PubMed=20935092; DOI=10.1128/jb.01158-10;
RA   Schutzer S.E., Fraser-Liggett C.M., Casjens S.R., Qiu W.G., Dunn J.J.,
RA   Mongodin E.F., Luft B.J.;
RT   "Whole-genome sequences of thirteen isolates of Borrelia burgdorferi.";
RL   J. Bacteriol. 193:1018-1020(2011).
CC   -!- FUNCTION: Virulence-associated protein essential for survival of the
CC       bacterium within the tick host and therefore within the natural life
CC       cycle of the Lyme disease spirochete. {ECO:0000269|PubMed:15860579}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BptA family. {ECO:0000305}.
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DR   EMBL; AY894345; AAX69072.1; -; Genomic_DNA.
DR   EMBL; CP002234; ADQ29948.1; -; Genomic_DNA.
DR   RefSeq; WP_010259717.1; NC_017420.1.
DR   AlphaFoldDB; E4QH55; -.
DR   KEGG; bbn:BbuN40_E05; -.
DR   PATRIC; fig|521007.3.peg.1035; -.
DR   HOGENOM; CLU_1329815_0_0_12; -.
DR   OMA; DPNINEK; -.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031471; BptA.
DR   Pfam; PF17044; BPTA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Plasmid; Signal; Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..206
FT                   /note="Protein BptA"
FT                   /id="PRO_0000406310"
FT   CONFLICT        2..3
FT                   /note="RE -> GK (in Ref. 1; AAX69072)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        11
FT                   /note="S -> L (in Ref. 1; AAX69072)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        17
FT                   /note="V -> G (in Ref. 1; AAX69072)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        42..43
FT                   /note="VI -> LV (in Ref. 1; AAX69072)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   206 AA;  24659 MW;  5961FF0B1A248653 CRC64;
     MREILFFGLL SICIFLVFFF YKQKENNIIY NRIVEKFEDN VVIDEIYTHL FKDSNLKELV
     FIKSQLIIPE LEHKKMIKAT GYRADAYKAL STVYRFDFKV HDNKILGFKS VIFEGFEDAK
     VSKHENNLPS EKWQQLKDFN IGDPNINEKF FHLEFPFVVK NTLCVTISKG FFKKIKKLKR
     LKIMLISNED REYKIDIENF LPKYNL