BPTA_BORBU
ID BPTA_BORBU Reviewed; 206 AA.
AC P0CL63; O50712; Q56NH3; Q56NH4;
DT 05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-APR-2011, sequence version 1.
DT 25-MAY-2022, entry version 40.
DE RecName: Full=Protein BptA;
DE AltName: Full=Borrelial persistence in ticks protein A;
DE Flags: Precursor;
GN Name=bptA; OrderedLocusNames=BB_E16;
OS Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS (Borrelia burgdorferi).
OG Plasmid lp25.
OC Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX NCBI_TaxID=224326;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC STRAIN=ATCC 53899 / 297;
RX PubMed=15860579; DOI=10.1073/pnas.0502565102;
RA Revel A.T., Blevins J.S., Almazan C., Neil L., Kocan K.M., de la Fuente J.,
RA Hagman K.E., Norgard M.V.;
RT "bptA (bbe16) is essential for the persistence of the Lyme disease
RT spirochete, Borrelia burgdorferi, in its natural tick vector.";
RL Proc. Natl. Acad. Sci. U.S.A. 102:6972-6977(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX PubMed=9403685; DOI=10.1038/37551;
RA Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA Smith H.O., Venter J.C.;
RT "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL Nature 390:580-586(1997).
CC -!- FUNCTION: Virulence-associated protein essential for survival of the
CC bacterium within the tick host and therefore within the natural life
CC cycle of the Lyme disease spirochete. {ECO:0000269|PubMed:15860579}.
CC -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the BptA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY894344; AAX69071.1; -; Genomic_DNA.
DR EMBL; AE000785; AAC66050.1; -; Genomic_DNA.
DR PIR; C70226; C70226.
DR RefSeq; NP_045423.1; NC_001850.1.
DR RefSeq; WP_010890264.1; NC_001850.1.
DR AlphaFoldDB; P0CL63; -.
DR EnsemblBacteria; AAC66050; AAC66050; BB_E16.
DR KEGG; bbu:BB_E16; -.
DR PATRIC; fig|224326.49.peg.1277; -.
DR HOGENOM; CLU_1329815_0_0_12; -.
DR OMA; DPNINEK; -.
DR Proteomes; UP000001807; Plasmid lp25.
DR GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR031471; BptA.
DR Pfam; PF17044; BPTA; 1.
PE 3: Inferred from homology;
KW Cell outer membrane; Membrane; Plasmid; Reference proteome; Signal;
KW Virulence.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..206
FT /note="Protein BptA"
FT /id="PRO_0000238481"
FT VARIANT 28
FT /note="V -> I (in strain: 297)"
FT VARIANT 72
FT /note="K -> E (in strain: 297)"
FT VARIANT 75..79
FT /note="KMIKA -> EMMKS (in strain: 297)"
FT VARIANT 184
FT /note="M -> I (in strain: 297)"
FT VARIANT 206
FT /note="L -> F (in strain: 297)"
SQ SEQUENCE 206 AA; 24534 MW; 25730555C70AE725 CRC64;
MGKILFFGLL LICIFLGFFF YKQKENNVIY NKIVEKFDDN VFVDETYTYL FKDSNLKELV
FIKSQLIIPE LKHKKMIKAT GYRADAYKAL STVYRFDFKV HDNKILGFKS VIFEGFEDAK
VSKHENNLPS EKWQQLKDFN IGDPNINEKF FHLEFPFVVK NTLCVTISKG FFKKIKKLKR
LKIMLISNED REYKIDIENF LPKYNL