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BPTA_BORBU
ID   BPTA_BORBU              Reviewed;         206 AA.
AC   P0CL63; O50712; Q56NH3; Q56NH4;
DT   05-APR-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 40.
DE   RecName: Full=Protein BptA;
DE   AltName: Full=Borrelial persistence in ticks protein A;
DE   Flags: Precursor;
GN   Name=bptA; OrderedLocusNames=BB_E16;
OS   Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)
OS   (Borrelia burgdorferi).
OG   Plasmid lp25.
OC   Bacteria; Spirochaetes; Spirochaetales; Borreliaceae; Borreliella.
OX   NCBI_TaxID=224326;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC   STRAIN=ATCC 53899 / 297;
RX   PubMed=15860579; DOI=10.1073/pnas.0502565102;
RA   Revel A.T., Blevins J.S., Almazan C., Neil L., Kocan K.M., de la Fuente J.,
RA   Hagman K.E., Norgard M.V.;
RT   "bptA (bbe16) is essential for the persistence of the Lyme disease
RT   spirochete, Borrelia burgdorferi, in its natural tick vector.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:6972-6977(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35210 / DSM 4680 / CIP 102532 / B31;
RX   PubMed=9403685; DOI=10.1038/37551;
RA   Fraser C.M., Casjens S., Huang W.M., Sutton G.G., Clayton R.A.,
RA   Lathigra R., White O., Ketchum K.A., Dodson R.J., Hickey E.K., Gwinn M.L.,
RA   Dougherty B.A., Tomb J.-F., Fleischmann R.D., Richardson D.L.,
RA   Peterson J.D., Kerlavage A.R., Quackenbush J., Salzberg S.L., Hanson M.,
RA   van Vugt R., Palmer N., Adams M.D., Gocayne J.D., Weidman J.F.,
RA   Utterback T.R., Watthey L., McDonald L.A., Artiach P., Bowman C.,
RA   Garland S.A., Fujii C., Cotton M.D., Horst K., Roberts K.M., Hatch B.,
RA   Smith H.O., Venter J.C.;
RT   "Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi.";
RL   Nature 390:580-586(1997).
CC   -!- FUNCTION: Virulence-associated protein essential for survival of the
CC       bacterium within the tick host and therefore within the natural life
CC       cycle of the Lyme disease spirochete. {ECO:0000269|PubMed:15860579}.
CC   -!- SUBCELLULAR LOCATION: Cell outer membrane {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the BptA family. {ECO:0000305}.
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DR   EMBL; AY894344; AAX69071.1; -; Genomic_DNA.
DR   EMBL; AE000785; AAC66050.1; -; Genomic_DNA.
DR   PIR; C70226; C70226.
DR   RefSeq; NP_045423.1; NC_001850.1.
DR   RefSeq; WP_010890264.1; NC_001850.1.
DR   AlphaFoldDB; P0CL63; -.
DR   EnsemblBacteria; AAC66050; AAC66050; BB_E16.
DR   KEGG; bbu:BB_E16; -.
DR   PATRIC; fig|224326.49.peg.1277; -.
DR   HOGENOM; CLU_1329815_0_0_12; -.
DR   OMA; DPNINEK; -.
DR   Proteomes; UP000001807; Plasmid lp25.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031471; BptA.
DR   Pfam; PF17044; BPTA; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Membrane; Plasmid; Reference proteome; Signal;
KW   Virulence.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..206
FT                   /note="Protein BptA"
FT                   /id="PRO_0000238481"
FT   VARIANT         28
FT                   /note="V -> I (in strain: 297)"
FT   VARIANT         72
FT                   /note="K -> E (in strain: 297)"
FT   VARIANT         75..79
FT                   /note="KMIKA -> EMMKS (in strain: 297)"
FT   VARIANT         184
FT                   /note="M -> I (in strain: 297)"
FT   VARIANT         206
FT                   /note="L -> F (in strain: 297)"
SQ   SEQUENCE   206 AA;  24534 MW;  25730555C70AE725 CRC64;
     MGKILFFGLL LICIFLGFFF YKQKENNVIY NKIVEKFDDN VFVDETYTYL FKDSNLKELV
     FIKSQLIIPE LKHKKMIKAT GYRADAYKAL STVYRFDFKV HDNKILGFKS VIFEGFEDAK
     VSKHENNLPS EKWQQLKDFN IGDPNINEKF FHLEFPFVVK NTLCVTISKG FFKKIKKLKR
     LKIMLISNED REYKIDIENF LPKYNL
 
 
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