ID   AC132_NPVAC             Reviewed;         219 AA.
AC   P24730;
DT   01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-1992, sequence version 1.
DT   29-SEP-2021, entry version 45.
DE   RecName: Full=Protein Ac132;
GN   Name=Ac132; ORFNames=ORF132;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3041026; DOI=10.1128/jvi.61.10.3048-3057.1987;
RA   Oellig C., Happ B., Mueller T., Doerfler W.;
RT   "Overlapping sets of viral RNAs reflect the array of polypeptides in the
RT   EcoRI J and N fragments (map positions 81.2 to 85.0) of the Autographa
RT   californica nuclear polyhedrosis virus genome.";
RL   J. Virol. 61:3048-3057(1987).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=20444894; DOI=10.1128/jvi.00040-10;
RA   Wang R., Deng F., Hou D., Zhao Y., Guo L., Wang H., Hu Z.;
RT   "Proteomics of the Autographa californica nucleopolyhedrovirus budded
RT   virions.";
RL   J. Virol. 84:7233-7242(2010).
RN   [4]
RP   FUNCTION, SUBCELLULAR LOCATION, AND INTERACTION WITH E18 AND P6.9.
RX   PubMed=25142609; DOI=10.1128/jvi.01313-14;
RA   Yang M., Wang S., Yue X.L., Li L.L.;
RT   "Autographa californica multiple nucleopolyhedrovirus orf132 encodes a
RT   nucleocapsid-associated protein required for budded-virus and multiply
RT   enveloped occlusion-derived virus production.";
RL   J. Virol. 88:12586-12598(2014).
RN   [5]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DOMAIN.
RX   PubMed=27608627; DOI=10.1099/jgv.0.000602;
RA   Fang Z., Li C., Wu W., Yuan M., Yang K.;
RT   "The Autographa californica multiple nucleopolyhedrovirus Ac132 plays a
RT   role in nuclear entry.";
RL   J. Gen. Virol. 97:3030-3038(2016).
CC   -!- FUNCTION: Plays an essential role in nucleocapsid entry in host
CC       nucleus. May act by binding and stabilizing F-actin in the infected
CC       cell, which might attach to nucleocapsids and then push the
CC       nucleocapsids into the nucleus. {ECO:0000269|PubMed:25142609,
CC       ECO:0000269|PubMed:27608627}.
CC   -!- SUBUNIT: Interacts with viral envelope protein E18 and the DNA-binding
CC       protein p6.9. {ECO:0000269|PubMed:25142609}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000269|PubMed:25142609}.
CC       Host nucleus {ECO:0000269|PubMed:25142609}. Virion
CC       {ECO:0000269|PubMed:20444894, ECO:0000269|PubMed:25142609}.
CC       Note=Present in both the budded virus (BV) and the occluded virus (OV).
CC       The occluded form allows the virus to be transmitted from insect to
CC       insect through ingestion of contaminated food while the budded form is
CC       responsible for the dissemination of infection throughout the insect
CC       host. {ECO:0000269|PubMed:25142609}.
CC   -!- DOMAIN: Contains a domain homologous to an NEBU domain that is known to
CC       bind actin. {ECO:0000269|PubMed:27608627}.
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DR   EMBL; M17548; AAA66806.1; -; Genomic_DNA.
DR   EMBL; L22858; AAA66762.1; -; Genomic_DNA.
DR   PIR; E72866; E72866.
DR   RefSeq; NP_054162.1; NC_001623.1.
DR   GeneID; 1403965; -.
DR   KEGG; vg:1403965; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042025; C:host cell nucleus; IDA:UniProtKB.
DR   GO; GO:0044423; C:virion component; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Host cytoplasm; Host nucleus; Late protein; Reference proteome; Virion.
FT   CHAIN           1..219
FT                   /note="Protein Ac132"
FT                   /id="PRO_0000133064"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          103..134
FT                   /note="NEBU-like domain"
FT                   /evidence="ECO:0000269|PubMed:27608627"
FT   COMPBIAS        20..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   219 AA;  25136 MW;  281E1625BE8F6A5E CRC64;
     MSDKTPTKKG GSHAMTLRER GVTKPPKKSE KLQQYKKAIA AEQTLRTTAD VSSLQNPGES
     AVFQELERLE NAVVVLENEQ KRLYPILDTP LDNFIVAFVN PTYPMAYFVN TDYKLKLECA
     RIRSDLLYKN KNEVAINRPK ISSFKLQLNN VILDTIETIE YDLQNKVLTI TAPVQDQELR
     KSIIYFNILN SDSWEVPKYM KKLFDEMQLE PPVILPLGL