ID   TATD1_ENCCU             Reviewed;         273 AA.
AC   Q8SW70;
DT   03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Putative deoxyribonuclease TATDN1 homolog;
DE            EC=3.1.21.-;
GN   OrderedLocusNames=ECU03_0200;
OS   Encephalitozoon cuniculi (strain GB-M1) (Microsporidian parasite).
OC   Eukaryota; Fungi; Fungi incertae sedis; Microsporidia; Unikaryonidae;
OC   Encephalitozoon.
OX   NCBI_TaxID=284813;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GB-M1;
RX   PubMed=11719806; DOI=10.1038/35106579;
RA   Katinka M.D., Duprat S., Cornillot E., Metenier G., Thomarat F.,
RA   Prensier G., Barbe V., Peyretaillade E., Brottier P., Wincker P.,
RA   Delbac F., El Alaoui H., Peyret P., Saurin W., Gouy M., Weissenbach J.,
RA   Vivares C.P.;
RT   "Genome sequence and gene compaction of the eukaryote parasite
RT   Encephalitozoon cuniculi.";
RL   Nature 414:450-453(2001).
CC   -!- FUNCTION: Putative deoxyribonuclease. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250};
CC       Note=Binds 2 divalent metal cations per subunit. {ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       TatD-type hydrolase family. {ECO:0000305}.
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DR   EMBL; AL590443; CAD26166.1; -; Genomic_DNA.
DR   RefSeq; NP_597531.1; NM_001040895.1.
DR   AlphaFoldDB; Q8SW70; -.
DR   SMR; Q8SW70; -.
DR   STRING; 284813.Q8SW70; -.
DR   GeneID; 858693; -.
DR   KEGG; ecu:ECU03_0200; -.
DR   VEuPathDB; MicrosporidiaDB:ECU03_0200; -.
DR   HOGENOM; CLU_031506_1_1_1; -.
DR   InParanoid; Q8SW70; -.
DR   OMA; DIAFNIT; -.
DR   OrthoDB; 1224437at2759; -.
DR   Proteomes; UP000000819; Chromosome III.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd01310; TatD_DNAse; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR001130; TatD-like.
DR   Pfam; PF01026; TatD_DNase; 1.
DR   PIRSF; PIRSF005902; DNase_TatD; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   3: Inferred from homology;
KW   Hydrolase; Metal-binding; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Putative deoxyribonuclease TATDN1 homolog"
FT                   /id="PRO_0000388425"
FT   BINDING         91
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
FT   BINDING         91
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         125
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         147
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250"
FT   BINDING         195
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   273 AA;  30639 MW;  491A5FE1D618528D CRC64;
     MLIDIAVNIT DKLLAKDESS VEEVIRRCKD SKVLPIFTGL DHQTSKICIN LAKKYKTVST
     AGIHPTSSSR YSNIDEIVPL VNDETVVAIG ECGLDYDRLE FADKVSQKRI FRSQLDLGGS
     CYFFHSRSCH RDFMEIVSDY RIRGVVHSFT GSIEEARELI KKGLFIGING CSVKTLEGIE
     IVRSLPLESL LIETDSPYCK IRRSYAGFEY VTTDFSQQKA LKKKNEPCCV VQMAEVVSNA
     TGKDYDLVVE TILDNTIGLY GDVLKKSVER WGL