ID   TATD3_BOVIN             Reviewed;         273 AA.
AC   A1A4M4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Putative deoxyribonuclease TATDN3;
DE            EC=3.1.21.-;
GN   Name=TATDN3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative deoxyribonuclease. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250|UniProtKB:Q17R31};
CC       Note=Binds 2 divalent metal cations per subunit.
CC       {ECO:0000250|UniProtKB:Q17R31};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       TatD-type hydrolase family. {ECO:0000305}.
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DR   EMBL; BC126724; AAI26725.1; -; mRNA.
DR   RefSeq; NP_001073789.1; NM_001080320.1.
DR   AlphaFoldDB; A1A4M4; -.
DR   SMR; A1A4M4; -.
DR   STRING; 9913.ENSBTAP00000048497; -.
DR   PaxDb; A1A4M4; -.
DR   PRIDE; A1A4M4; -.
DR   Ensembl; ENSBTAT00000052023; ENSBTAP00000048497; ENSBTAG00000024443.
DR   GeneID; 615965; -.
DR   KEGG; bta:615965; -.
DR   CTD; 128387; -.
DR   VEuPathDB; HostDB:ENSBTAG00000024443; -.
DR   VGNC; VGNC:35618; TATDN3.
DR   eggNOG; KOG3020; Eukaryota.
DR   GeneTree; ENSGT00720000108846; -.
DR   HOGENOM; CLU_031506_5_3_1; -.
DR   InParanoid; A1A4M4; -.
DR   OMA; CHLDAGE; -.
DR   OrthoDB; 988732at2759; -.
DR   TreeFam; TF314175; -.
DR   Proteomes; UP000009136; Chromosome 16.
DR   Bgee; ENSBTAG00000024443; Expressed in caput epididymis and 107 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd01310; TatD_DNAse; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR001130; TatD-like.
DR   Pfam; PF01026; TatD_DNase; 1.
DR   PIRSF; PIRSF005902; DNase_TatD; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..273
FT                   /note="Putative deoxyribonuclease TATDN3"
FT                   /id="PRO_0000313594"
FT   BINDING         12
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         14
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         107
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         107
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         147
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         170
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         217
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
SQ   SEQUENCE   273 AA;  30013 MW;  C67CC6A4D4ABD498 CRC64;
     MGAVGVGLVD CHCHLSAPDF DHDLDDVLKK AKEANVMALV VVAEHSGEFE KIMQLSQRYN
     GFVLPCLGVH PVQGVSPEDQ RSVTLKDLDV ALPIIENYKD QLLAIGEVGL DFSPRFAGTD
     EQKEEQRQVL IRQVQLAKRL NLPLNVHSRS AGRPTISLLN EQGADKVLLH AFDGRPSVAM
     EGVKAGYFFS IPPSIIRSGQ QKLVKQLPLT SICLETDSPA LGPEKQVRNE PRNISISAEY
     IAQVKGVSVE EVIEVTTQNA LKLFPKLQRL LPK