ID   TATD3_DANRE             Reviewed;         266 AA.
AC   Q503T5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Putative deoxyribonuclease tatdn3;
DE            EC=3.1.21.-;
GN   Name=tatdn3; ORFNames=zgc:110166;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Putative deoxyribonuclease. {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC         Evidence={ECO:0000250|UniProtKB:Q17R31};
CC       Note=Binds 2 divalent metal cations per subunit.
CC       {ECO:0000250|UniProtKB:Q17R31};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       TatD-type hydrolase family. {ECO:0000305}.
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DR   EMBL; BC095191; AAH95191.1; -; mRNA.
DR   RefSeq; NP_001018405.1; NM_001020569.1.
DR   AlphaFoldDB; Q503T5; -.
DR   SMR; Q503T5; -.
DR   STRING; 7955.ENSDARP00000127347; -.
DR   GeneID; 553592; -.
DR   KEGG; dre:553592; -.
DR   CTD; 128387; -.
DR   ZFIN; ZDB-GENE-050522-192; tatdn3.
DR   eggNOG; KOG3020; Eukaryota.
DR   InParanoid; Q503T5; -.
DR   OrthoDB; 988732at2759; -.
DR   PhylomeDB; Q503T5; -.
DR   PRO; PR:Q503T5; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd01310; TatD_DNAse; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR001130; TatD-like.
DR   Pfam; PF01026; TatD_DNase; 1.
DR   PIRSF; PIRSF005902; DNase_TatD; 1.
DR   SUPFAM; SSF51556; SSF51556; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Metal-binding; Nuclease; Nucleus; Reference proteome.
FT   CHAIN           1..266
FT                   /note="Putative deoxyribonuclease tatdn3"
FT                   /id="PRO_0000313597"
FT   BINDING         9
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         11
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         103
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         103
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         143
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         166
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
FT   BINDING         214
FT                   /ligand="a divalent metal cation"
FT                   /ligand_id="ChEBI:CHEBI:60240"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000250|UniProtKB:Q17R31"
SQ   SEQUENCE   266 AA;  29517 MW;  E8A3419AECC10B5A CRC64;
     MARGFIDCHC HISASEFTTD TDDVLLRAKK AGVKALVAVT EGASEFEKVI QLSKTYPGFV
     FPCFGIHPLQ GSGQDLHSVR VQDLDPFLYL FQTYKDDIVA IGEIGLDFTP WYSSITQERD
     EQMKVFIKQL EISKELDLPV NVHSRSSAKV TIATMKELGI RQALLHNFAG KPSVAMEGVQ
     AGFCFSFPPA VSKNEQRAKL IRQIPLEHVC LETDSPALGL DKHVRNEPSN VTISCEYIAK
     VKGISSDVVM EVTTQNALRL FSKLKI