TATD3_HUMAN
ID TATD3_HUMAN Reviewed; 274 AA.
AC Q17R31; A6NGS3; B7Z1C1; B7Z978; B7ZLQ6; E9PJE5; E9PNH3; G3V151; Q4G0L1;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Putative deoxyribonuclease TATDN3;
DE EC=3.1.21.-;
GN Name=TATDN3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
RC TISSUE=Uterus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=24275569; DOI=10.1016/j.jprot.2013.11.014;
RA Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L.,
RA Ye M., Zou H.;
RT "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver
RT phosphoproteome.";
RL J. Proteomics 96:253-262(2014).
RN [7]
RP X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 5-274 IN COMPLEX WITH ZINC IONS,
RP AND COFACTOR.
RG Structural genomics consortium (SGC);
RT "Crystal structure of the human tatD-domain protein 3 (TATDN3).";
RL Submitted (DEC-2010) to the PDB data bank.
CC -!- FUNCTION: Putative deoxyribonuclease.
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0007744|PDB:2Y1H};
CC Note=Binds 2 divalent metal cations per subunit.
CC {ECO:0007744|PDB:2Y1H};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=5;
CC Name=1;
CC IsoId=Q17R31-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q17R31-2; Sequence=VSP_030048;
CC Name=3;
CC IsoId=Q17R31-3; Sequence=VSP_044448;
CC Name=4;
CC IsoId=Q17R31-4; Sequence=VSP_045263;
CC Name=5;
CC IsoId=Q17R31-5; Sequence=VSP_044448, VSP_045742;
CC -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC TatD-type hydrolase family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH48115.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK293129; BAH11457.1; -; mRNA.
DR EMBL; AK304557; BAH14214.1; -; mRNA.
DR EMBL; AC104333; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471100; EAW93376.1; -; Genomic_DNA.
DR EMBL; CH471100; EAW93377.1; -; Genomic_DNA.
DR EMBL; CH471100; EAW93378.1; -; Genomic_DNA.
DR EMBL; BC048115; AAH48115.1; ALT_INIT; mRNA.
DR EMBL; BC113638; AAI13639.1; -; mRNA.
DR EMBL; BC117485; AAI17486.1; -; mRNA.
DR EMBL; BC143956; AAI43957.1; -; mRNA.
DR CCDS; CCDS31019.1; -. [Q17R31-1]
DR CCDS; CCDS41465.1; -. [Q17R31-2]
DR CCDS; CCDS53475.1; -. [Q17R31-3]
DR CCDS; CCDS53476.1; -. [Q17R31-5]
DR CCDS; CCDS53477.1; -. [Q17R31-4]
DR RefSeq; NP_001036017.1; NM_001042552.2. [Q17R31-1]
DR RefSeq; NP_001036018.1; NM_001042553.2. [Q17R31-2]
DR RefSeq; NP_001139641.1; NM_001146169.1. [Q17R31-5]
DR RefSeq; NP_001139642.1; NM_001146170.1. [Q17R31-4]
DR RefSeq; NP_001139643.1; NM_001146171.1. [Q17R31-3]
DR PDB; 2Y1H; X-ray; 2.50 A; A/B=5-274.
DR PDBsum; 2Y1H; -.
DR AlphaFoldDB; Q17R31; -.
DR SMR; Q17R31; -.
DR BioGRID; 126118; 6.
DR IntAct; Q17R31; 4.
DR STRING; 9606.ENSP00000431376; -.
DR iPTMnet; Q17R31; -.
DR PhosphoSitePlus; Q17R31; -.
DR BioMuta; TATDN3; -.
DR DMDM; 121948822; -.
DR EPD; Q17R31; -.
DR jPOST; Q17R31; -.
DR MassIVE; Q17R31; -.
DR MaxQB; Q17R31; -.
DR PaxDb; Q17R31; -.
DR PeptideAtlas; Q17R31; -.
DR PRIDE; Q17R31; -.
DR ProteomicsDB; 21114; -.
DR ProteomicsDB; 22414; -.
DR ProteomicsDB; 32260; -.
DR ProteomicsDB; 61133; -. [Q17R31-1]
DR ProteomicsDB; 61134; -. [Q17R31-2]
DR Antibodypedia; 51781; 30 antibodies from 13 providers.
DR DNASU; 128387; -.
DR Ensembl; ENST00000366973.8; ENSP00000355940.4; ENSG00000203705.11. [Q17R31-2]
DR Ensembl; ENST00000366974.9; ENSP00000355941.4; ENSG00000203705.11. [Q17R31-1]
DR Ensembl; ENST00000526641.5; ENSP00000434801.1; ENSG00000203705.11. [Q17R31-4]
DR Ensembl; ENST00000531963.5; ENSP00000433755.1; ENSG00000203705.11. [Q17R31-5]
DR Ensembl; ENST00000532324.5; ENSP00000431376.1; ENSG00000203705.11. [Q17R31-3]
DR GeneID; 128387; -.
DR KEGG; hsa:128387; -.
DR MANE-Select; ENST00000366974.9; ENSP00000355941.4; NM_001042552.3; NP_001036017.1.
DR UCSC; uc001hjo.3; human. [Q17R31-1]
DR CTD; 128387; -.
DR GeneCards; TATDN3; -.
DR HGNC; HGNC:27010; TATDN3.
DR HPA; ENSG00000203705; Low tissue specificity.
DR neXtProt; NX_Q17R31; -.
DR OpenTargets; ENSG00000203705; -.
DR PharmGKB; PA142670831; -.
DR VEuPathDB; HostDB:ENSG00000203705; -.
DR eggNOG; KOG3020; Eukaryota.
DR GeneTree; ENSGT00720000108846; -.
DR HOGENOM; CLU_031506_5_3_1; -.
DR InParanoid; Q17R31; -.
DR OMA; CHLDAGE; -.
DR OrthoDB; 988732at2759; -.
DR PhylomeDB; Q17R31; -.
DR PathwayCommons; Q17R31; -.
DR SignaLink; Q17R31; -.
DR BioGRID-ORCS; 128387; 16 hits in 1083 CRISPR screens.
DR ChiTaRS; TATDN3; human.
DR GenomeRNAi; 128387; -.
DR Pharos; Q17R31; Tdark.
DR PRO; PR:Q17R31; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q17R31; protein.
DR Bgee; ENSG00000203705; Expressed in left ventricle myocardium and 191 other tissues.
DR ExpressionAtlas; Q17R31; baseline and differential.
DR Genevisible; Q17R31; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR CDD; cd01310; TatD_DNAse; 1.
DR InterPro; IPR032466; Metal_Hydrolase.
DR InterPro; IPR001130; TatD-like.
DR Pfam; PF01026; TatD_DNase; 1.
DR PIRSF; PIRSF005902; DNase_TatD; 1.
DR SUPFAM; SSF51556; SSF51556; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Alternative splicing; Hydrolase; Metal-binding; Nuclease;
KW Nucleus; Reference proteome.
FT CHAIN 1..274
FT /note="Putative deoxyribonuclease TATDN3"
FT /id="PRO_0000313595"
FT BINDING 12
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT BINDING 14
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT BINDING 107
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT BINDING 107
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT BINDING 147
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT BINDING 170
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="2"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT BINDING 218
FT /ligand="a divalent metal cation"
FT /ligand_id="ChEBI:CHEBI:60240"
FT /ligand_label="1"
FT /evidence="ECO:0007744|PDB:2Y1H"
FT VAR_SEQ 87..107
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_045263"
FT VAR_SEQ 200
FT /note="Q -> QLLSLFSK (in isoform 3 and isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044448"
FT VAR_SEQ 201
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_030048"
FT VAR_SEQ 228..274
FT /note="VRNEPWNISISAEYIAQVKGISVEEVIEVTTQNALKLFPKLRHLLQK -> Q
FT NILPR (in isoform 5)"
FT /evidence="ECO:0000305"
FT /id="VSP_045742"
FT CONFLICT 86
FT /note="K -> R (in Ref. 1; BAH11457)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="A -> T (in Ref. 1; BAH11457)"
FT /evidence="ECO:0000305"
FT CONFLICT 231
FT /note="E -> G (in Ref. 1; BAH14214)"
FT /evidence="ECO:0000305"
FT STRAND 8..13
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 18..20
FT /evidence="ECO:0007829|PDB:2Y1H"
FT TURN 21..23
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 24..33
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 36..41
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 46..48
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 49..58
FT /evidence="ECO:0007829|PDB:2Y1H"
FT TURN 59..62
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 63..67
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 85..98
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 99..101
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 103..109
FT /evidence="ECO:0007829|PDB:2Y1H"
FT TURN 114..116
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 120..140
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 144..147
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 152..161
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 166..170
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 176..184
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 188..191
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 193..196
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 199..207
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 210..212
FT /evidence="ECO:0007829|PDB:2Y1H"
FT STRAND 213..215
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 232..234
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 235..246
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 250..264
FT /evidence="ECO:0007829|PDB:2Y1H"
FT HELIX 268..271
FT /evidence="ECO:0007829|PDB:2Y1H"
SQ SEQUENCE 274 AA; 30333 MW; D2428A5666E164A5 CRC64;
MRAAGVGLVD CHCHLSAPDF DRDLDDVLEK AKKANVVALV AVAEHSGEFE KIMQLSERYN
GFVLPCLGVH PVQGLPPEDQ RSVTLKDLDV ALPIIENYKD RLLAIGEVGL DFSPRFAGTG
EQKEEQRQVL IRQIQLAKRL NLPVNVHSRS AGRPTINLLQ EQGAEKVLLH AFDGRPSVAM
EGVRAGYFFS IPPSIIRSGQ KQKLVKQLPL TSICLETDSP ALGPEKQVRN EPWNISISAE
YIAQVKGISV EEVIEVTTQN ALKLFPKLRH LLQK
