ID   TATR_NPVOP              Reviewed;         560 AA.
AC   P22114;
DT   01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1991, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Trans-activating transcriptional regulatory protein;
DE   AltName: Full=Immediate early protein 1;
DE            Short=IE-1;
GN   Name=IE1; ORFNames=ORF145;
OS   Orgyia pseudotsugata multicapsid polyhedrosis virus (OpMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=262177;
OH   NCBI_TaxID=33414; Orgyia pseudotsugata (Douglas-fir tussock moth).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1989381; DOI=10.1016/0042-6822(91)90063-h;
RA   Theilmann D.A., Stewart S.;
RT   "Identification and characterization of the IE-1 gene of Orgyia
RT   pseudotsugata multicapsid nuclear polyhedrosis virus.";
RL   Virology 180:492-508(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=9126251; DOI=10.1006/viro.1997.8448;
RA   Ahrens C.H., Russell R.R., Funk C.J., Evans J., Harwood S., Rohrmann G.F.;
RT   "The sequence of the Orgyia pseudotsugata multinucleocapsid nuclear
RT   polyhedrosis virus genome.";
RL   Virology 229:381-399(1997).
CC   -!- FUNCTION: Regulatory transcriptional protein, which trans-activates
CC       gene expression from early baculovirus promoters. Can also trans-
CC       activate its own promoter, suggesting that it is autoregulated during
CC       normal infection of insect cells.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=2 isoforms may be produced.;
CC       Name=1;
CC         IsoId=P22114-1; Sequence=Displayed;
CC   -!- SIMILARITY: Belongs to the nucleopolyhedrovirus IE-1 protein family.
CC       {ECO:0000305}.
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DR   EMBL; M63414; AAA46700.1; -; Genomic_DNA.
DR   EMBL; U75930; AAC59144.1; -; Genomic_DNA.
DR   PIR; A38544; RGNVPM.
DR   RefSeq; NP_046301.1; NC_001875.2. [P22114-1]
DR   PRIDE; P22114; -.
DR   GeneID; 912062; -.
DR   KEGG; vg:912062; -.
DR   Proteomes; UP000009248; Genome.
DR   GO; GO:0019079; P:viral genome replication; ISS:UniProtKB.
DR   InterPro; IPR005092; TATR.
DR   Pfam; PF03430; TATR; 1.
PE   3: Inferred from homology;
KW   Alternative splicing; Early protein; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..560
FT                   /note="Trans-activating transcriptional regulatory protein"
FT                   /id="PRO_0000132848"
FT   REGION          1..25
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          99..134
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        112..131
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   560 AA;  64316 MW;  3991D4261A4B9BDD CRC64;
     MPKNMETLQR SYMGPSTPNH NLFNNATELP DDLNFSTMDV PYDGSMPMNM SSDSLMNLLE
     DRSKKLACAV DTELARESTA SEFVAGFSAD SPQAQLAETG AETGAAGGSK RKASEVDSDS
     DSDDSSKGKK LVNKPKIRQR YKKATIQNRT SLTEERQYST EICTVAAPDQ IAKYFAQDFS
     AHLNEVKSEC QMSANRFSDY ISETGYYVFV VKKGDRKPFE VVFAKFVNNA TNEYTNNYYM
     VDNRVFVVSL NNVKFMVSYK LVREQGIDIP PHVNLCNDAQ AERTPLNCYF EPVKNAFQAT
     LINHFHLDMF YAQTTFVTLM QAVGENKTNM LLNKLYQMYQ DRSLFTLPIM LSRKEPVNEN
     APQNKNHAFS YVAQIMKYSK NLRFPQGDPT QQVMDRLEEI VTQKSSLTYK YSSVANLLFN
     RYGRRDNNAD ALKKVKKEDG NRLLVEQYMS YNENDDTSHN FIVLQFGGVN DERLTIAKRG
     KEFYWIAGEI KDISVDDLIK KYARNVHHVF RIINVNRRES TTWHNNLLKL LQLLLQNLIR
     LEDVQRYSDK SDTKFVYKKV