TAX4_YEAST
ID TAX4_YEAST Reviewed; 604 AA.
AC P47030; D6VWA0;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Protein TAX4;
GN Name=TAX4; OrderedLocusNames=YJL083W; ORFNames=J1002;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=7483841; DOI=10.1002/yea.320110709;
RA Miosga T., Schaaff-Gerstenschlaeger I., Chalwatzis N., Baur A., Boles E.,
RA Fournier C., Schmitt S., Velten C., Wilhelm N., Zimmermann F.K.;
RT "Sequence analysis of a 33.1 kb fragment from the left arm of Saccharomyces
RT cerevisiae chromosome X, including putative proteins with leucine zippers,
RT a fungal Zn(II)2-Cys6 binuclear cluster domain and a putative alpha 2-SCB-
RT alpha 2 binding site.";
RL Yeast 11:681-689(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP DOMAIN.
RX PubMed=9822599; DOI=10.1093/emboj/17.22.6541;
RA Paoluzi S., Castagnoli L., Lauro I., Salcini A.E., Coda L., Fre' S.,
RA Confalonieri S., Pelicci P.G., Di Fiore P.P., Cesareni G.;
RT "Recognition specificity of individual EH domains of mammals and yeast.";
RL EMBO J. 17:6541-6550(1998).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
RN [6]
RP FUNCTION, AND INTERACTION WITH INP51.
RX PubMed=15265867; DOI=10.1074/jbc.m405589200;
RA Morales-Johansson H., Jenoe P., Cooke F.T., Hall M.N.;
RT "Negative regulation of phosphatidylinositol 4,5-bisphosphate levels by the
RT INP51-associated proteins TAX4 and IRS4.";
RL J. Biol. Chem. 279:39604-39610(2004).
CC -!- FUNCTION: With IRS4, acts as a positive regulator of INP51 activity and
CC phosphatidylinositol 4,5-bisphosphate turnover. Negatively regulates
CC signaling through the cell integrity pathway, including the MAP kinase
CC SLT2. {ECO:0000269|PubMed:15265867}.
CC -!- SUBUNIT: Interacts with INP51. {ECO:0000269|PubMed:15265867}.
CC -!- INTERACTION:
CC P47030; P40559: INP51; NbExp=3; IntAct=EBI-25970, EBI-24915;
CC -!- MISCELLANEOUS: Present with 396 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the IRS4 family. {ECO:0000305}.
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DR EMBL; Z49358; CAA89376.1; -; Genomic_DNA.
DR EMBL; X83502; CAA58487.1; -; Genomic_DNA.
DR EMBL; X88851; CAA61318.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08716.1; -; Genomic_DNA.
DR PIR; S56027; S56027.
DR RefSeq; NP_012452.1; NM_001181516.1.
DR AlphaFoldDB; P47030; -.
DR SMR; P47030; -.
DR BioGRID; 33673; 120.
DR IntAct; P47030; 5.
DR MINT; P47030; -.
DR STRING; 4932.YJL083W; -.
DR MaxQB; P47030; -.
DR PaxDb; P47030; -.
DR PRIDE; P47030; -.
DR EnsemblFungi; YJL083W_mRNA; YJL083W; YJL083W.
DR GeneID; 853362; -.
DR KEGG; sce:YJL083W; -.
DR SGD; S000003619; TAX4.
DR VEuPathDB; FungiDB:YJL083W; -.
DR eggNOG; KOG0998; Eukaryota.
DR GeneTree; ENSGT00940000176414; -.
DR HOGENOM; CLU_452143_0_0_1; -.
DR InParanoid; P47030; -.
DR OMA; RSSXVGS; -.
DR BioCyc; YEAST:G3O-31540-MON; -.
DR PRO; PR:P47030; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P47030; protein.
DR GO; GO:0000407; C:phagophore assembly site; IDA:SGD.
DR GO; GO:0006914; P:autophagy; IGI:SGD.
DR GO; GO:0009267; P:cellular response to starvation; IGI:SGD.
DR GO; GO:0031505; P:fungal-type cell wall organization; IGI:SGD.
DR GO; GO:0048017; P:inositol lipid-mediated signaling; IGI:SGD.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd00052; EH; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR000261; EH_dom.
DR SMART; SM00027; EH; 1.
DR SUPFAM; SSF47473; SSF47473; 1.
PE 1: Evidence at protein level;
KW Lipid metabolism; Reference proteome.
FT CHAIN 1..604
FT /note="Protein TAX4"
FT /id="PRO_0000203050"
FT DOMAIN 469..559
FT /note="EH"
FT REGION 38..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 132..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..380
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 394..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..419
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 604 AA; 68768 MW; E17C6C71D9FBFBD6 CRC64;
MHFPKKKHSG NLSVVELPKE ALQDSLTAAQ ITFKRYAHPN GNAGSAERPR HLKVESAPVV
KSEPSLPRMR QPEPRSINHQ YSRETLPGHS EAFSVPTTPL QTIHYDVRNK ASNSPSSIAA
AETAAYLAHT NSFSNRSSGV GSRDPVMDTE TKPPRAPSAL KNELQLNRMR IPPPSYDNNV
RSRSISPQVS YSTSLSSSCS ISSDGEETSY REKSTDEAFP PEPSMSSYSL ASKASAKASL
TDPSQRQQES DYTAMNKLNG GNIIYKGTLP DLIPRSQRKT SKPRFKHRLL RSPEQQQENL
SRVYSDQTQN GRAIINTQQN VKLKTTMRRG KYAITDNDET FPYDRKSVSS DSDTDEDSNV
MEIKDKKKKS RRSKIKKGLK TTAAVVGSST SVLPFPHHHH HHHQLHNPNS HHLHTHHHTS
SHKFNEDKPW KSHRDLGFIT EQERKRYESM WVSNRYSYLR LLPWWPSLAN EDDESHLQPL
NLPQDGLMLN LVVKDIWYRS NLPRDLLVQI YNMVDTRKDG TLDRKSFIVG MWLVDQCLYG
RKLTNELDQR VWNSVDGYVL GTINVKPATS DHYHNANNPL DKPSKLSVRQ ELKNIKRDLR
NVRI
