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TAX_HTL32
ID   TAX_HTL32               Reviewed;         350 AA.
AC   Q0R5R1;
DT   14-NOV-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   02-JUN-2021, entry version 48.
DE   RecName: Full=Protein Tax-3;
DE   AltName: Full=Trans-activating transcriptional regulatory protein of HTLV-3;
GN   Name=tax;
OS   Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Deltaretrovirus.
OX   NCBI_TaxID=402036;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16840323; DOI=10.1128/jvi.00690-06;
RA   Switzer W.M., Qari S.H., Wolfe N.D., Burke D.S., Folks T.M., Heneine W.;
RT   "Ancient origin and molecular features of the novel human T-lymphotropic
RT   virus type 3 revealed by complete genome analysis.";
RL   J. Virol. 80:7427-7438(2006).
CC   -!- FUNCTION: Transcriptional activator that activates both the viral long
CC       terminal repeat (LTR) and cellular promoters via activation of CREB,
CC       NF-kappa-B, SRF and AP-1 pathways. Binds to two 21 bp repeat elements
CC       located within the LTRs, referred to as Tax-responsive element (TRE).
CC       Binding to TRE requires the interaction with CREB1 and CREBBP.
CC       Activation of NF-kappa-B leads to up-regulation of the expression of
CC       gene promoters containing NFkB motifs like IL8 or BCL2L1. Inhibits the
CC       action of p53/TP53 and MYCB. All these functions could lead to the
CC       possible occurrence of lymphoproliferative disorders. Required for
CC       viral replication (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with host CREB1, CREBBP and EP300 (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000250}. Host cytoplasm
CC       {ECO:0000250}. Note=Shuttles from the nucleus to the cytoplasm. Found
CC       predominantly in the nucleus (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The 48 N-terminal residues contain a non-canonical functional
CC       nuclear localization signal (NLS). {ECO:0000250}.
CC   -!- DOMAIN: The PDZ-binding domain may mediate binding to PDZ-containing
CC       proteins and could be a factor of pathogenicity.
CC   -!- PTM: Phosphorylation at Thr-48 results in the loss of NF-kappa-B
CC       activation function. Phosphorylation at Thr-215 results in loss of CREB
CC       and NF-B responsive promoters activation. Phosphorylation at Thr-184
CC       has no effect on these functions. Phosphorylation of either Ser-300 or
CC       Ser-301 is necessary for localization to nuclear bodies. Thr-48, Thr-
CC       184 and Thr-215 are highly phosphorylated, whereas Ser-300 or Ser-301
CC       are only rarely phosphorylated (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the deltaretrovirus Tax protein family.
CC       {ECO:0000305}.
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DR   EMBL; DQ093792; AAZ77661.1; -; Genomic_DNA.
DR   PRIDE; Q0R5R1; -.
DR   Proteomes; UP000008029; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0017124; F:SH3 domain binding; IEA:UniProtKB-KW.
DR   GO; GO:0039646; P:modulation by virus of host G0/G1 transition checkpoint; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:InterPro.
DR   InterPro; IPR004120; Tax.
DR   Pfam; PF02959; Tax; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding;
KW   G0/G1 host cell cycle checkpoint dysregulation by virus; Host cytoplasm;
KW   Host nucleus; Host-virus interaction; Metal-binding;
KW   Modulation of host cell cycle by virus; Oncogene; Phosphoprotein;
KW   Reference proteome; SH3-binding; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..350
FT                   /note="Protein Tax-3"
FT                   /id="PRO_0000259952"
FT   ZN_FING         23..49
FT                   /evidence="ECO:0000255"
FT   REGION          1..58
FT                   /note="Interaction with CREB1"
FT                   /evidence="ECO:0000250"
FT   REGION          81..95
FT                   /note="Interaction with CREBBP/P300"
FT                   /evidence="ECO:0000250"
FT   REGION          106..111
FT                   /note="Interaction with IKBKG"
FT                   /evidence="ECO:0000250"
FT   REGION          116..145
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          213..248
FT                   /note="Homodimerization"
FT                   /evidence="ECO:0000250"
FT   REGION          289..322
FT                   /note="Transactivation"
FT                   /evidence="ECO:0000250"
FT   REGION          312..319
FT                   /note="Interaction with CREBBP C-terminus"
FT                   /evidence="ECO:0000250"
FT   REGION          326..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           73..80
FT                   /note="SH3-binding"
FT                   /evidence="ECO:0000255"
FT   MOTIF           188..202
FT                   /note="Nuclear export signal"
FT                   /evidence="ECO:0000250"
FT   MOTIF           347..350
FT                   /note="PDZ-binding"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         48
FT                   /note="Phosphothreonine; by host"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         184
FT                   /note="Phosphothreonine; by host"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         215
FT                   /note="Phosphothreonine; by host"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         300
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         301
FT                   /note="Phosphoserine; by host"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   350 AA;  39016 MW;  49CA21BD87179258 CRC64;
     MAHFPGFGQS LLYGYPVYVF GDCVQADWCP ISGGLCSARL HRHALLATCP EHQITWDPID
     GRVVSSALQY LIPRLPSFPT QRTTRTLKVL TPPTTAATPK IPPSFFHAVK KHTPFRNNCL
     ELTLGEQLPA MSFPDPGLRP QNIYTMWGSS VVCLYLYQLS PPMTWPLIPH VIFCHPEQLG
     AFLTRVPTKR LEELLYKIFL STGAIIILPE NCFPTTLFQP TRAPAVQAPW HTGLLPCQKE
     IATPGLIWTF TDGSPMISGP CPKEGQPSLV VQSSTFIFQQ FQTKASHPAF LLSHKLIHYS
     SFHSLHLLFE EYTTIPFSLL FNEKGANVDD DEPRDGSQPP ARGQIAESPV
 
 
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