ID   TAZK_ASPTN              Reviewed;         356 AA.
AC   Q0CS98;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 69.
DE   RecName: Full=MFS-type transporter tazK {ECO:0000303|PubMed:35398258};
DE   AltName: Full=Azaphilone biosynthesis cluster protein K {ECO:0000303|PubMed:35398258};
GN   Name=tazK {ECO:0000303|PubMed:35398258}; ORFNames=ATEG_03436;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INDUCTION, AND PATHWAY.
RX   PubMed=35398258; DOI=10.1016/j.fgb.2022.103694;
RA   Sun W.W., Li C.Y., Chiang Y.M., Lin T.S., Warren S., Chang F.R.,
RA   Wang C.C.C.;
RT   "Characterization of a silent azaphilone biosynthesis gene cluster in
RT   Aspergillus terreus NIH 2624.";
RL   Fungal Genet. Biol. 160:103694-103694(2022).
CC   -!- FUNCTION: MFS-type transporter; part of the gene cluster that mediates
CC       the biosynthesis of azaterrilone A and other azaphilones, a class of
CC       fungal metabolites characterized by a highly oxygenated pyrano-quinone
CC       bicyclic core and exhibiting a broad range of bioactivities.
CC       {ECO:0000269|PubMed:35398258}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Expression is positively regulated by the azaterrilone A
CC       cluster-specific transcription factor tazR.
CC       {ECO:0000269|PubMed:35398258}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. CAR1 family.
CC       {ECO:0000255}.
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DR   EMBL; CH476597; EAU36710.1; -; Genomic_DNA.
DR   RefSeq; XP_001212614.1; XM_001212614.1.
DR   STRING; 33178.CADATEAP00010351; -.
DR   EnsemblFungi; EAU36710; EAU36710; ATEG_03436.
DR   GeneID; 4318031; -.
DR   VEuPathDB; FungiDB:ATEG_03436; -.
DR   eggNOG; KOG0255; Eukaryota.
DR   HOGENOM; CLU_008455_11_0_1; -.
DR   OMA; VYLVHAN; -.
DR   OrthoDB; 911338at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR005829; Sugar_transporter_CS.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
DR   PROSITE; PS00216; SUGAR_TRANSPORT_1; 1.
PE   2: Evidence at transcript level;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..356
FT                   /note="MFS-type transporter tazK"
FT                   /id="PRO_0000456068"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        42..62
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        69..89
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        178..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        257..277
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        288..308
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   356 AA;  38296 MW;  E0690F49234808F9 CRC64;
     MGPASEVYGR KLPFFLGYVL FVLSQIPVAL GHDAPTVLVF RFLGGVTSSV CPAITGGWLA
     DFLLPAERGV AVAIFAATTL VGPSIGAITS QVQLQTAMGW RMTAWTTMIL GIVSGVAGFI
     ILPETYLPVV EQRHARKLRQ ETKDWALHSR LDEKPVSIRE FLTKYLTLPI SMLVSEPILL
     SMTIYISFTF GLIYLLFVAY PVSFVQERGY GAIDGTLPLL SICAGIIVGA FYASWSTLTT
     VKQKAASGNA LVPEDRLHPM IVGAVSLAIG LLWFAWTSSP AISPWPQILA GIPIGVGVQV
     ILLQSLAYLI DIYTTGAASA ISGTMIVRSL VGGTFPLFAP QMYRKFGVSI AVLIIQ