ID   TAZR_ASPTN              Reviewed;         632 AA.
AC   Q0CS89;
DT   03-AUG-2022, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   03-AUG-2022, entry version 87.
DE   RecName: Full=Transcription factor tazR {ECO:0000303|PubMed:35398258};
DE   AltName: Full=Azaphilone biosynthesis cluster protein R {ECO:0000303|PubMed:35398258};
GN   Name=tazR {ECO:0000303|PubMed:35398258}; ORFNames=ATEG_03445;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION.
RX   PubMed=35398258; DOI=10.1016/j.fgb.2022.103694;
RA   Sun W.W., Li C.Y., Chiang Y.M., Lin T.S., Warren S., Chang F.R.,
RA   Wang C.C.C.;
RT   "Characterization of a silent azaphilone biosynthesis gene cluster in
RT   Aspergillus terreus NIH 2624.";
RL   Fungal Genet. Biol. 160:103694-103694(2022).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of azaterrilone A and other
CC       azaphilones, a class of fungal metabolites characterized by a highly
CC       oxygenated pyrano-quinone bicyclic core and exhibiting a broad range of
CC       bioactivities. {ECO:0000269|PubMed:35398258}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00227}.
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DR   EMBL; CH476597; EAU36719.1; -; Genomic_DNA.
DR   RefSeq; XP_001212623.1; XM_001212623.1.
DR   EnsemblFungi; EAU36719; EAU36719; ATEG_03445.
DR   GeneID; 4317678; -.
DR   VEuPathDB; FungiDB:ATEG_03445; -.
DR   eggNOG; ENOG502SH49; Eukaryota.
DR   HOGENOM; CLU_011017_3_1_1; -.
DR   OMA; WISASRC; -.
DR   OrthoDB; 455010at2759; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR   CDD; cd00067; GAL4; 1.
DR   Gene3D; 4.10.240.10; -; 1.
DR   InterPro; IPR007219; Transcription_factor_dom_fun.
DR   InterPro; IPR001138; Zn2-C6_fun-type_DNA-bd.
DR   InterPro; IPR036864; Zn2-C6_fun-type_DNA-bd_sf.
DR   Pfam; PF04082; Fungal_trans; 1.
DR   Pfam; PF00172; Zn_clus; 1.
DR   SMART; SM00906; Fungal_trans; 1.
DR   SMART; SM00066; GAL4; 1.
DR   SUPFAM; SSF57701; SSF57701; 1.
DR   PROSITE; PS00463; ZN2_CY6_FUNGAL_1; 1.
DR   PROSITE; PS50048; ZN2_CY6_FUNGAL_2; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           1..632
FT                   /note="Transcription factor tazR"
FT                   /id="PRO_0000456063"
FT   DNA_BIND        20..47
FT                   /note="Zn(2)-C6 fungal-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00227"
SQ   SEQUENCE   632 AA;  70817 MW;  C5DFE4650C2A6786 CRC64;
     MSPSLNEPER LNRQAQGLAC NECRARKLRC DRVRPTCGTC ESLGVTCTPN SVRQPRGPRK
     GYLKTLQSRI SALERQWNGQ QKAAGGSPGE SPPCSEGGQT LRAVSESTSD GVHDEDHANG
     ARPPSSQSSI EQPILQPTVS LDGISALHGF APVNSPFAFA LPGTDPSKTV DLFSHMECFP
     SMPTKLDPRA YVPQQLTPNS TMSNGQFDLP TDLSVTSEFQ LPELMKADLS HLYFDRVHPF
     APILNKRRYF ARAARPVSEQ GAMTCLQHAM WTLAAWLGSQ FKHIQKDLYI YTRGLLEKWE
     LNMHPGNPPI ELAQARLFLA IYEIMQVNYE RGWLSAGRCF RLIQLMKLHE IDVPDGISES
     GISFGEIEER RRTFWMAYSL DRFINLINKM PLTLNEQVIF TRLPAPEGAF QRERPVQTQF
     LSEFMAGDDD LQIVSPFSAC IVVMTISGRC LSHQQQCMVE RAYGGMPQDF ITRHQWLEGI
     LMSKGKAIVD CISNDLDDEL TDPMLLFTNM AAHATTLLLG MTMQTGLCNY ESLISGFEER
     ATEAAQKILH LCQRLNECGY FKVHPFTPIP LVFCAEWAQG RKNQNPAFEP LHNSMLCSLR
     DLSVVNMLAE TCLARLNDSN PQMETDMSKS QS