TB182_MOUSE
ID TB182_MOUSE Reviewed; 1720 AA.
AC P58871; A2BH84; Q6ZPI8;
DT 20-JUN-2002, integrated into UniProtKB/Swiss-Prot.
DT 29-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=182 kDa tankyrase-1-binding protein;
GN Name=Tnks1bp1; Synonyms=Kiaa1741, Tab182;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 397-1720.
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 812-1720.
RC TISSUE=Colon, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-533; SER-539; SER-568;
RP SER-796; SER-887; SER-1131; SER-1212; SER-1290; SER-1375; SER-1611 AND
RP SER-1612, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=17242355; DOI=10.1073/pnas.0609836104;
RA Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P.;
RT "Large-scale phosphorylation analysis of mouse liver.";
RL Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Liver;
RX PubMed=18630941; DOI=10.1021/pr800223m;
RA Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.;
RT "Specific phosphopeptide enrichment with immobilized titanium ion affinity
RT chromatography adsorbent for phosphoproteome analysis.";
RL J. Proteome Res. 7:3957-3967(2008).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1611 AND SER-1612, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic fibroblast;
RX PubMed=19131326; DOI=10.1074/mcp.m800451-mcp200;
RA Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.;
RT "Large scale localization of protein phosphorylation by use of electron
RT capture dissociation mass spectrometry.";
RL Mol. Cell. Proteomics 8:904-912(2009).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-300; SER-429; SER-496;
RP SER-500; THR-503; THR-533; SER-539; SER-568; SER-713; SER-796; SER-887;
RP SER-1022; SER-1063; SER-1131; SER-1212; SER-1246; THR-1275; SER-1290;
RP SER-1373; SER-1375; SER-1437; SER-1442; SER-1611; SER-1612 AND SER-1657,
RP AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas,
RC Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Binds to the ANK repeat domain of TNKS1 and TNKS2.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton
CC {ECO:0000250}. Chromosome {ECO:0000250}. Note=Colocalizes with
CC chromosomes during mitosis, and in the cytoplasm with cortical actin.
CC {ECO:0000250}.
CC -!- PTM: ADP-ribosylated by TNKS1. {ECO:0000250}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAM22340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; BX546441; CAM22340.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AK129436; BAC98246.1; -; mRNA.
DR EMBL; BC024499; AAH24499.1; -; mRNA.
DR EMBL; BC025943; AAH25943.1; -; mRNA.
DR CCDS; CCDS38166.1; -.
DR RefSeq; NP_001074729.1; NM_001081260.2.
DR RefSeq; XP_017173105.1; XM_017317616.1.
DR AlphaFoldDB; P58871; -.
DR BioGRID; 230718; 15.
DR IntAct; P58871; 13.
DR MINT; P58871; -.
DR STRING; 10090.ENSMUSP00000107232; -.
DR iPTMnet; P58871; -.
DR PhosphoSitePlus; P58871; -.
DR EPD; P58871; -.
DR jPOST; P58871; -.
DR MaxQB; P58871; -.
DR PaxDb; P58871; -.
DR PeptideAtlas; P58871; -.
DR PRIDE; P58871; -.
DR ProteomicsDB; 263070; -.
DR Antibodypedia; 27306; 217 antibodies from 27 providers.
DR Ensembl; ENSMUST00000111605; ENSMUSP00000107232; ENSMUSG00000033955.
DR GeneID; 228140; -.
DR KEGG; mmu:228140; -.
DR UCSC; uc012byp.1; mouse.
DR CTD; 85456; -.
DR MGI; MGI:2446193; Tnks1bp1.
DR VEuPathDB; HostDB:ENSMUSG00000033955; -.
DR eggNOG; ENOG502QSXZ; Eukaryota.
DR GeneTree; ENSGT00940000154184; -.
DR HOGENOM; CLU_003005_0_0_1; -.
DR InParanoid; P58871; -.
DR OMA; DQEFGKS; -.
DR OrthoDB; 64879at2759; -.
DR PhylomeDB; P58871; -.
DR TreeFam; TF336029; -.
DR Reactome; R-MMU-429947; Deadenylation of mRNA.
DR Reactome; R-MMU-6804115; TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain.
DR BioGRID-ORCS; 228140; 4 hits in 70 CRISPR screens.
DR ChiTaRS; Tnks1bp1; mouse.
DR PRO; PR:P58871; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; P58871; protein.
DR Bgee; ENSMUSG00000033955; Expressed in embryonic brain and 168 other tissues.
DR ExpressionAtlas; P58871; baseline and differential.
DR Genevisible; P58871; MM.
DR GO; GO:0005912; C:adherens junction; ISO:MGI.
DR GO; GO:0030014; C:CCR4-NOT complex; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000792; C:heterochromatin; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0071532; F:ankyrin repeat binding; ISO:MGI.
DR GO; GO:0019899; F:enzyme binding; ISO:MGI.
DR GO; GO:0044877; F:protein-containing complex binding; ISO:MGI.
DR GO; GO:0071479; P:cellular response to ionizing radiation; ISO:MGI.
DR GO; GO:0006302; P:double-strand break repair; ISO:MGI.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; ISO:MGI.
DR GO; GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation; ISO:MGI.
DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; ISO:MGI.
DR InterPro; IPR032764; Tankyrase-bd_C.
DR InterPro; IPR040006; TNKS1BP1-like.
DR PANTHER; PTHR22042; PTHR22042; 1.
DR Pfam; PF15327; Tankyrase_bdg_C; 1.
DR SMART; SM01319; Tankyrase_bdg_C; 1.
PE 1: Evidence at protein level;
KW ADP-ribosylation; Chromosome; Cytoplasm; Cytoskeleton; Methylation;
KW Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..1720
FT /note="182 kDa tankyrase-1-binding protein"
FT /id="PRO_0000072438"
FT REGION 1..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 185..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 209..1563
FT /note="Acidic"
FT REGION 485..595
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 659..720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 734..925
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..1081
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1128..1153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1198..1255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1358..1546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1440..1532
FT /note="Tankyrase-binding"
FT /evidence="ECO:0000250"
FT REGION 1567..1720
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 1620..1626
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT MOTIF 1714..1719
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 58..72
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..376
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..680
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 734..762
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 780..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 837..862
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 970..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 986..1011
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1065
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1398..1415
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1425..1462
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1511..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1596..1622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1652..1667
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 14
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 131
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 178
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 220
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 238
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 286
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 300
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 429
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 437
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 496
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 500
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 503
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 533
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 539
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 568
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 602
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 673
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 692
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 713
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 763
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 796
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 807
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 845
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 866
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 871
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 876
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 887
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 912
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 976
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 980
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1006
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1017
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1022
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1047
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1063
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1084
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1096
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1126
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1131
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1171
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1212
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1241
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1246
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1275
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1290
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1321
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1324
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1373
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1375
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 1425
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1429
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1437
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1440
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1442
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1463
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1466
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1496
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1549
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1554
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1611
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079"
FT MOD_RES 1612
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17242355,
FT ECO:0007744|PubMed:19131326, ECO:0007744|PubMed:21183079"
FT MOD_RES 1622
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1635
FT /note="N6-methyllysine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1643
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT MOD_RES 1657
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 1706
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9C0C2"
FT CONFLICT 941
FT /note="N -> D (in Ref. 2; BAC98246 and 3; AAH25943)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1720 AA; 181825 MW; 7CFF0046559B923D CRC64;
MKGSTLREGT AMASPLPQDM EEELAPVGSE PGDPRAKPPV KPKPRGLPSK PALPAKPSLL
VPVGPRPPRG PLAELPSARK MNMLAGPQPY GVSKRPLPFA PRPSAEATAG GDVTQESGKE
DAGKEDLPPL TPPARCAALG GVRKAPAPFR PSSERFAACT VEEILAKMEQ PRKEILASPD
RLWGSRLTFN HDGSSRYGPR TYGAPCPREE DSKSPAKGRS QEGTAEIPAE CQEEHSKTPE
ERNLTSSPAM NGDLAKLACS EAPTDVSKTW VTSSADPVSE HGGSTSAVRL ANISVPASES
PRLSSRPSSP CHSQLSETQS PAASEASSIC LPVTPASPSA VLPAEPPGHS PSSELPAEAA
PETLSPNSSP VETVSGHHSP EQPPVLLPQL LTEGAELPDI TRTFPCGEEA AARGHTESRP
SSLAQRRFSE GVLQPPSQDQ EKLGGSLATL PQGQGSQSAL DRPFGSGTES NWSLSQSFEW
TFPTRPSGLG VWRLDSPPPS PITEASEAAE AAEADSWAVS GRGEGVSQVG PGTPPAPESP
RKPISGVQGN DPGISLPQRD DGESQPRSPA LLPSTVEGPP GAPLLQAKEN YEDQEPLVGH
ESPITLAARE AALPVLEPAL GQQQPTPSDQ PCILFVDVPD PEQALSTEED VVTLGWAETT
LPMTEAQEPC SVSPEPTGPE SSSRWLDDLL ASPPPNSGSA RRAAGAELKD RQSPSTCSEG
LLGWAQKDLQ SEFGVATDSH HSSFGSSSWS QDTSQNYSLG GRSPVGDTGL GKRDWSSKCG
QGSGEGSTRE WASRHSLGQE VIGIGGSQDE SEVPVRERAV GRPAQLGAQG LEADAQQWEF
GKRESQDPHS IHDKELQDQE FGKRDSLGSF STRDASLQDW EFGKRASVST NQDTDENDQE
LGMKNLSRGY SSQDAEEQDR EFEKRDSVLD IHGSRATAQQ NQEFGKSAWF QDYSSGGGGS
RVLGSQERGF GIRSLSSGFS PEEAQQQDEE FEKKTPVGED RFCEASRDVG HLEEGASGGL
LSPSTPHSRD GAARPKDEGS WQDGDSSQEI TRLQGRMQAE SQSPTNVDLE DKEREQRGWA
GEFSLGVAAQ SEAAFSPGRQ DWSRDVCVEA SESSYQFGII GNDRVSGAGL SPSRKSGGGH
FVPPGETKAG AVDWTDQLGL RNLEVSSCVS SEGPSEAREN VVGQMGWSDS LGLNNGDLAR
RLGTGESEEP RSLGVGEKDW TSSVEARNRD LPGQAEVGRH SQARESGVGE PDWSGAEAGE
FLKSRERGVG QADWTPDLGL RNMAPGAGCS PGEPRELGVG QVDWGDDLGL RNLEVSCDLE
SGGSRGCGVG QMDWAQDLGL RNLRLCGAPS EVRECGVGRV GPDLELDPKS SGSLSPGLET
EDPLEARELG VGEISGPETQ GEDSSSPSFE TPSEDTGMDT GEAPSLGASP SSCLTRSPPS
GSQSLLEGIM TASSSKGAPQ RESAASGSRV LLEEEGLAAG AGQGEPQEPS RAPLPSSRPQ
PDGEASQVEE VDGTWSLTGA ARQNEQASAP PPRRPPRGLL PSCPSEDFSF IEDTEILDSA
MYRSRANLGR KRGHRAPAIR PGGTLGLSET ADSDTRLFQD STEPRASRVP SSDEEVVEEP
QSRRTRMSLG TKGLKVNLFP GLSPSALKAK LRSRNRSAEE GEVTESKSSQ KESSVQRSKS
CKVPGLGKPL TLPPKPEKSS GSEGSSPNWL QALKLKKKKI
