ID   TB1RB_XENLA             Reviewed;         522 AA.
AC   Q6GPC6;
DT   24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=F-box-like/WD repeat-containing protein TBL1XR1-B;
DE   AltName: Full=Nuclear receptor corepressor/HDAC3 complex subunit TBLR1-B;
DE   AltName: Full=TBL1-related protein 1-B;
DE   AltName: Full=Transducin beta-like 1X-related homolog 1-B;
GN   Name=tbl1xr1-b; Synonyms=tblr1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: F-box-like protein which acts as an integral component of the
CC       N-CoR transcriptional corepressor complex. Probably regulates
CC       transcription activation mediated by nuclear receptors. May mediate the
CC       recruitment of the 19S proteasome complex, leading to the subsequent
CC       proteasomal degradation of the N-CoR complex, thereby allowing cofactor
CC       exchange and transcription activation (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with heterodimers of rxra and thrb, and this
CC       interaction is abrogated by thyroid hormone binding to thrb. Interacts
CC       with ncor1 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The F-box-like domain is related to the F-box domain, and also
CC       functions to recruit ubiquitin E3 ligase complexes. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat EBI family. {ECO:0000305}.
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DR   EMBL; BC073215; AAH73215.1; -; mRNA.
DR   RefSeq; NP_001090456.1; NM_001096987.1.
DR   RefSeq; XP_018120115.1; XM_018264626.1.
DR   AlphaFoldDB; Q6GPC6; -.
DR   SMR; Q6GPC6; -.
DR   DNASU; 779369; -.
DR   GeneID; 779369; -.
DR   KEGG; xla:779369; -.
DR   CTD; 779369; -.
DR   Xenbase; XB-GENE-864821; tbl1xr1.S.
DR   OMA; XTGALVH; -.
DR   OrthoDB; 1463197at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 779369; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR   GO; GO:0016575; P:histone deacetylation; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR045183; Ebi-like.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR22846; PTHR22846; 1.
DR   Pfam; PF08513; LisH; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 4.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Activator; Chromatin regulator; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation;
KW   Ubl conjugation pathway; WD repeat.
FT   CHAIN           1..522
FT                   /note="F-box-like/WD repeat-containing protein TBL1XR1-B"
FT                   /id="PRO_0000051269"
FT   DOMAIN          4..36
FT                   /note="LisH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00126"
FT   DOMAIN          41..86
FT                   /note="F-box-like"
FT   REPEAT          175..214
FT                   /note="WD 1"
FT   REPEAT          231..270
FT                   /note="WD 2"
FT   REPEAT          272..311
FT                   /note="WD 3"
FT   REPEAT          314..352
FT                   /note="WD 4"
FT   REPEAT          355..394
FT                   /note="WD 5"
FT   REPEAT          397..445
FT                   /note="WD 6"
FT   REPEAT          448..487
FT                   /note="WD 7"
FT   REPEAT          489..522
FT                   /note="WD 8"
FT   REGION          122..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   522 AA;  56285 MW;  4FB0F58F503B461F CRC64;
     MSISSDEVNF LVYRYLQESG FSHSAFTFGI ESHISQSNIN GALVPPAALI SIIQKGLQYV
     EAEVSINEDG TLFDGRPIES LSLIDAVMPD VVQTRQQAYR DKLAQQQQAA AAAAAAAAAA
     AATSANNQQP PAKNGESTAN GEENGGHALA NNHTDMMEVD GDVEIPPSKA VVLRGHESEV
     FICAWNPVSD LLASGSGDST ARIWNLSENS TSGSTQLVLR HCIREGGQDV PSNKDVTSLD
     WNSEGTLLAT GSYDGFARIW TKDGNLASTL GQHKGPIFAL KWNKKGNFIL SAGVDKTTII
     WDAHTGEAKQ QFPFHSAPAL DVDWQSNNTF ASCSTDMCIH VCKLGQDRPI KTFQGHTNEV
     NAIKWDPTGN LLASCSDDMT LKIWSMKHDT CVHDLQAHNK EIYTIKWSPT GPGTNNPNAN
     LMLASASFDS TVRLWDVDRG ICIHTLTKHQ EPVYSVAFSP DGRYLASGSF DKCVHIWNTQ
     TGALVHSYRG TGGIFEVCWN AAGDKVGASA SDGSVCVLDL RK