ID   TB22A_MACFA             Reviewed;         497 AA.
AC   Q95KI1;
DT   08-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2002, sequence version 2.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=TBC1 domain family member 22A;
DE   Flags: Fragment;
GN   Name=TBC1D22A; ORFNames=QtrA-11492;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a GTPase-activating protein for Rab family
CC       protein(s). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with ACBD3 and ARFGEF1. Interacts with
CC       YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ.
CC       {ECO:0000250|UniProtKB:Q8WUA7}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB46876.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB060857; BAB46876.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q95KI1; -.
DR   SMR; Q95KI1; -.
DR   STRING; 9541.XP_005567035.1; -.
DR   eggNOG; KOG1092; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0071889; F:14-3-3 protein binding; ISS:UniProtKB.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR   GO; GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
DR   InterPro; IPR000195; Rab-GTPase-TBC_dom.
DR   InterPro; IPR035969; Rab-GTPase_TBC_sf.
DR   Pfam; PF00566; RabGAP-TBC; 1.
DR   SMART; SM00164; TBC; 1.
DR   SUPFAM; SSF47923; SSF47923; 2.
DR   PROSITE; PS50086; TBC_RABGAP; 1.
PE   2: Evidence at transcript level;
KW   GTPase activation; Phosphoprotein; Reference proteome.
FT   CHAIN           <1..497
FT                   /note="TBC1 domain family member 22A"
FT                   /id="PRO_0000208052"
FT   DOMAIN          202..426
FT                   /note="Rab-GAP TBC"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00163"
FT   REGION          83..147
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..147
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         112
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WUA7"
FT   MOD_RES         125
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R5A6"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8R5A6"
FT   NON_TER         1
SQ   SEQUENCE   497 AA;  56810 MW;  47EF1098A998937A CRC64;
     SIQHVYGAQH PPFDPLLHGT LLKSTAKMPT TPVKAKRVST FQEFESNTSD AWDAGEDDDE
     LLAMAAESLN SEVVMETANR VLRNHSQRQG RPTLQEGPGL QQKPRPEAEP PSPPSGDLRL
     VKSVSESHTS CPAESASDAA PLQRSQSLPH AAAVTLGGTS DPGTLSSSAL SEREASRLDK
     FEQLLAGPNT DLEELRKLSW SGIPKPVRPM TWKLLSGYLP ANVDRRPATL QRKQKEYFAF
     IEHYYDSRND EVHQDTYRQI HIDIPRMSPE ALILQPKVTE IFERILFIWA IRHPASGYVQ
     GINDLVTPFF VVFICEYIEA EEVDTVDVSG VPAEVLRNIE ADTYWCMSKL LDGIQDNYTF
     AQPGIQMKVK MLEELVSRID EQVHRHLDQH EVRYLQFAFR WMNNLLMREV PLRCTIRLWD
     TYQSEPEGFS HFHLYVCAAF LVRWRKEILE EKDFQELLLF LQNLPTAHWD DEDISLLLAE
     AYRLKFAFAD APNHYKK