ID   AC18_NPVAC              Reviewed;         353 AA.
AC   P12828;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Protein AC18;
GN   Name=DA41; ORFNames=ORF18;
OS   Autographa californica nuclear polyhedrosis virus (AcMNPV).
OC   Viruses; Naldaviricetes; Lefavirales; Baculoviridae; Alphabaculovirus.
OX   NCBI_TaxID=46015;
OH   NCBI_TaxID=7088; Lepidoptera (butterflies and moths).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=E2;
RX   PubMed=2826808; DOI=10.1128/jvi.62.2.463-471.1988;
RA   Guarino L.A., Summers M.D.;
RT   "Functional mapping of Autographa california nuclear polyhedrosis virus
RT   genes required for late gene expression.";
RL   J. Virol. 62:463-471(1988).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION.
RC   STRAIN=E2;
RX   PubMed=1333113; DOI=10.1016/0042-6822(92)90281-s;
RA   Braunagel S.C., Daniel K.D., Reilly L.M., Guarino L.A., Hong T.,
RA   Summers M.D.;
RT   "Sequence, genomic organization of the EcoRI-A fragment of Autographa
RT   californica nuclear polyhedrosis virus, and identification of a viral-
RT   encoded protein resembling the outer capsid protein VP8 of rotavirus.";
RL   Virology 191:1003-1008(1992).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C6;
RX   PubMed=8030224; DOI=10.1006/viro.1994.1380;
RA   Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.;
RT   "The complete DNA sequence of Autographa californica nuclear polyhedrosis
RT   virus.";
RL   Virology 202:586-605(1994).
RN   [4]
RP   SUBCELLULAR LOCATION, FUNCTION, AND INDUCTION.
RX   PubMed=17573091; DOI=10.1016/j.virol.2007.05.017;
RA   Wang Y., Wu W., Li Z., Yuan M., Feng G., Yu Q., Yang K., Pang Y.;
RT   "ac18 is not essential for the propagation of Autographa californica
RT   multiple nucleopolyhedrovirus.";
RL   Virology 367:71-81(2007).
CC   -!- FUNCTION: May play a role in occlusion-derived virions (ODV) formation
CC       and/or regulation of late viral gene expression.
CC       {ECO:0000269|PubMed:17573091}.
CC   -!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000269|PubMed:17573091}. Host
CC       cytoplasm {ECO:0000269|PubMed:17573091}. Note=Localizes within the host
CC       nucleus few hours after infection while in the late phase of virus
CC       infection mainly localizes into the intranuclear ring zone where
CC       occlusion-derived virions (ODVs) formation occurs.
CC       {ECO:0000269|PubMed:17573091}.
CC   -!- INDUCTION: Early protein. {ECO:0000269|PubMed:17573091}.
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DR   EMBL; M18857; AAA66810.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; M96361; AAA66788.1; -; Genomic_DNA.
DR   EMBL; L22858; AAA66648.1; -; Genomic_DNA.
DR   PIR; B72852; B72852.
DR   PIR; C29891; WMNV49.
DR   PIR; C44221; C44221.
DR   RefSeq; NP_054047.1; NC_001623.1.
DR   GeneID; 1403850; -.
DR   KEGG; vg:1403850; -.
DR   Proteomes; UP000008292; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR010785; AcMNPV_AC18.
DR   Pfam; PF07134; DUF1383; 1.
PE   2: Evidence at transcript level;
KW   Early protein; Host cytoplasm; Host nucleus; Reference proteome.
FT   CHAIN           1..353
FT                   /note="Protein AC18"
FT                   /id="PRO_0000132861"
SQ   SEQUENCE   353 AA;  40870 MW;  EE81073B07909DCA CRC64;
     MERLLNQLNL GVLPYITTKD IEDRLRDKIV AKAKLAFIKD CFEAVVCENG GLFVLTGGAA
     VTCHIDDDRS ALKCIDFDYY GFCAKMFCNL QTNLQKCVDQ HYAELDVLTR QVYMSDPLVV
     LKCYQNGAYR LNGQINLHLN RHIKCIKTQY NDEFDLVRFA LQIDITSADG VDEYTDNGVK
     ITTAPLSFNV FFVNVRIMKR PFNADRCIKN FSLFGNEYHV LVSSLQRVLN DQLMCLLKDI
     FTNKFDYKIE RRLKHLKRLF ANLPAESYNS CVNDHTDMCL YKEQNETITN FVKKILDISG
     PALGCRKLMH IYLTTDTFSG QLPAYLTHYV NYPHKSLCDQ NWKRFMSCIF SLY