TBA2_NEUCR
ID TBA2_NEUCR Reviewed; 449 AA.
AC P38669; Q7RVI2;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 13-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Tubulin alpha-B chain;
GN Name=tba-2; ORFNames=B10K17.080, NCU09468;
OS Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS FGSC 987).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX NCBI_TaxID=367110;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=74-ORS-6a / FGSC 4200;
RX PubMed=9163903; DOI=10.1111/j.1574-6968.1997.tb10346.x;
RA Monnat J., Ortega Perez R., Turian G.;
RT "Molecular cloning and expression studies of two divergent alpha-tubulin
RT genes in Neurospora crassa.";
RL FEMS Microbiol. Lett. 150:33-41(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12655011; DOI=10.1093/nar/gkg293;
RA Mannhaupt G., Montrone C., Haase D., Mewes H.-W., Aign V., Hoheisel J.D.,
RA Fartmann B., Nyakatura G., Kempken F., Maier J., Schulte U.;
RT "What's in the genome of a filamentous fungus? Analysis of the Neurospora
RT genome sequence.";
RL Nucleic Acids Res. 31:1944-1954(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX PubMed=12712197; DOI=10.1038/nature01554;
RA Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT "The genome sequence of the filamentous fungus Neurospora crassa.";
RL Nature 422:859-868(2003).
CC -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC two moles of GTP, one at an exchangeable site on the beta chain and one
CC at a non-exchangeable site on the alpha chain.
CC -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC hollow water-filled tube with an outer diameter of 25 nm and an inner
CC diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC form protofilaments running lengthwise along the microtubule wall with
CC the beta-tubulin subunit facing the microtubule plus end conferring a
CC structural polarity. Microtubules usually have 13 protofilaments but
CC different protofilament numbers can be found in some organisms and
CC specialized cells.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR EMBL; X79404; CAA55941.1; -; mRNA.
DR EMBL; BX842596; CAE75716.1; -; Genomic_DNA.
DR EMBL; CM002237; EAA33987.1; -; Genomic_DNA.
DR PIR; S45051; S45051.
DR RefSeq; XP_963223.1; XM_958130.3.
DR AlphaFoldDB; P38669; -.
DR SMR; P38669; -.
DR STRING; 5141.EFNCRP00000009282; -.
DR PRIDE; P38669; -.
DR EnsemblFungi; EAA33987; EAA33987; NCU09468.
DR GeneID; 3879371; -.
DR KEGG; ncr:NCU09468; -.
DR VEuPathDB; FungiDB:NCU09468; -.
DR HOGENOM; CLU_015718_1_0_1; -.
DR InParanoid; P38669; -.
DR OMA; KVGICYQ; -.
DR Proteomes; UP000001805; Chromosome 6, Linkage Group II.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0005819; C:spindle; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR GO; GO:0000280; P:nuclear division; IBA:GO_Central.
DR GO; GO:0098863; P:nuclear migration by microtubule mediated pushing forces; IBA:GO_Central.
DR Gene3D; 1.10.287.600; -; 1.
DR Gene3D; 3.30.1330.20; -; 1.
DR Gene3D; 3.40.50.1440; -; 1.
DR InterPro; IPR002452; Alpha_tubulin.
DR InterPro; IPR013838; Beta-tubulin_BS.
DR InterPro; IPR008280; Tub_FtsZ_C.
DR InterPro; IPR000217; Tubulin.
DR InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR InterPro; IPR023123; Tubulin_C.
DR InterPro; IPR017975; Tubulin_CS.
DR InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR PANTHER; PTHR11588; PTHR11588; 1.
DR Pfam; PF00091; Tubulin; 1.
DR Pfam; PF03953; Tubulin_C; 1.
DR PRINTS; PR01162; ALPHATUBULIN.
DR PRINTS; PR01161; TUBULIN.
DR SMART; SM00864; Tubulin; 1.
DR SMART; SM00865; Tubulin_C; 1.
DR SUPFAM; SSF52490; SSF52490; 1.
DR SUPFAM; SSF55307; SSF55307; 1.
DR PROSITE; PS00227; TUBULIN; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..449
FT /note="Tubulin alpha-B chain"
FT /id="PRO_0000048200"
FT BINDING 142..148
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT SITE 449
FT /note="Involved in polymerization"
FT /evidence="ECO:0000250"
FT CONFLICT 60..62
FT /note="KYV -> NTF (in Ref. 1; CAA55941)"
FT /evidence="ECO:0000305"
FT CONFLICT 197..198
FT /note="HA -> QRR (in Ref. 1; CAA55941)"
FT /evidence="ECO:0000305"
FT CONFLICT 367..373
FT /note="DLAKVNR -> RSGPRLTD (in Ref. 1; CAA55941)"
FT /evidence="ECO:0000305"
FT CONFLICT 391..395
FT /note="LSSKF -> SFVQV (in Ref. 1; CAA55941)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 449 AA; 49966 MW; 9642CD388F1BAA10 CRC64;
MREIISLNVG QAGCQIANSC WELYCLEHGI QPDGYLTEER KAADPDHGFS TFFSETGNGK
YVPRTIYADL EPNVIDEVRT GAYRGLFHPE HMISGKEDAS NNYARGHYTV GKELIDQVLD
KVRRVADNCS GLQGFLVFHS FGGGTGSGFG ALLMERLSVD YGKKSKLEFC VYPAPQTATS
VVEPYNSILT THTTLEHADC SFMVDNEAIY DICRRNLGLE RPNYENLNRL IAQVVSSITA
SLRFDGSLNV DLNEFQTNLV PYPRIHFPLV AYAPVISAAK AAHEANSVQE MTMSCFEPNN
QMVKCDPRHG KYMATCLLYR GDVVPNDAHA AVATLKTKRT IQFVDWCPTG FKLGICYQPP
HQVPNGDLAK VNRAVCMLSN TTAIAEAWSA LSSKFDLMYS KRAFVHWYVG EGMEEGEFSE
AREDLAALER DYEEVAADSM EGEDVEAEY
