ID   TBA8_CAEEL              Reviewed;         452 AA.
AC   P52274;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 2.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Tubulin alpha-8 chain;
GN   Name=tba-8; ORFNames=ZK899.4;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; Z37140; CAA85497.2; -; Genomic_DNA.
DR   PIR; T28089; T28089.
DR   RefSeq; NP_509591.2; NM_077190.4.
DR   AlphaFoldDB; P52274; -.
DR   SMR; P52274; -.
DR   BioGRID; 55990; 1.
DR   STRING; 6239.ZK899.4; -.
DR   EPD; P52274; -.
DR   PaxDb; P52274; -.
DR   PeptideAtlas; P52274; -.
DR   PRIDE; P52274; -.
DR   EnsemblMetazoa; ZK899.4.1; ZK899.4.1; WBGene00006534.
DR   GeneID; 191455; -.
DR   KEGG; cel:CELE_ZK899.4; -.
DR   UCSC; ZK899.4; c. elegans.
DR   CTD; 191455; -.
DR   WormBase; ZK899.4; CE37468; WBGene00006534; tba-8.
DR   eggNOG; KOG1376; Eukaryota.
DR   HOGENOM; CLU_015718_0_0_1; -.
DR   InParanoid; P52274; -.
DR   OMA; RKQTEQC; -.
DR   OrthoDB; 514396at2759; -.
DR   PhylomeDB; P52274; -.
DR   PRO; PR:P52274; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006534; Expressed in ventral cord neuron (C elegans) and 8 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IBA:GO_Central.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   GO; GO:0000278; P:mitotic cell cycle; IBA:GO_Central.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002452; Alpha_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   InterPro; IPR017975; Tubulin_CS.
DR   InterPro; IPR003008; Tubulin_FtsZ_GTPase.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF00091; Tubulin; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01162; ALPHATUBULIN.
DR   PRINTS; PR01161; TUBULIN.
DR   SMART; SM00864; Tubulin; 1.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
DR   PROSITE; PS00227; TUBULIN; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..452
FT                   /note="Tubulin alpha-8 chain"
FT                   /id="PRO_0000048145"
FT   BINDING         145..151
FT                   /ligand="GTP"
FT                   /ligand_id="ChEBI:CHEBI:37565"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   452 AA;  50491 MW;  39E746E552304808 CRC64;
     MPSDGRECVS IHIGQAGAQI GNACWELYCI EHGLDEAGFL KEEEKNKKQQ SLQAFFSESM
     NGKHVPRAIY VDLEPTVLDE IRNGVYGNLF HPDQIINGKE DAANNYARGH YTIGKELIDV
     VLDRIRKQTE NCEGLQGFLV FHSFGGGTGS GFSSLLMERL SVEFGKKSKL EFSVYPAPQV
     STSVVEPYNS ILTTHTTLEL SDCSFMVDNE AIYDLCRQKL HVERPSYSNL NRLIAQVVSS
     ITASLRFDGA LNVDLNEFQT NLVPYPRIHF PLATYAPVIS ADRAHHEPLS VQDITHMCFE
     KANQMVKCDP SAGKYMAVCL LYRGDVVPKD VNAAISSVKA KRGINFVDWC PTGFKVGINY
     QAPITVEGGD LAKVHRAVCM LSNTTAIAEA WARLDHKFDL MYSKRAFVHW FVGEGMEEGE
     FMEARDDLAA LEKDYAEVSR DTADLEEEND EF