ID   TBAA_PNECA              Reviewed;         212 AA.
AC   Q07972;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Tubulin alpha chain;
DE   Flags: Fragment;
GN   Name=TUB-A;
OS   Pneumocystis carinii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
OX   NCBI_TaxID=4754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8292993; DOI=10.1111/j.1550-7408.1993.tb04468.x;
RA   Stringer J.R., Stringer S.L., Zhang J., Baughman R., Smulian A.G.,
RA   Cushion M.T.;
RT   "Molecular genetic distinction of Pneumocystis carinii from rats and
RT   humans.";
RL   J. Eukaryot. Microbiol. 40:733-741(1993).
CC   -!- FUNCTION: Tubulin is the major constituent of microtubules. It binds
CC       two moles of GTP, one at an exchangeable site on the beta chain and one
CC       at a non-exchangeable site on the alpha chain.
CC   -!- SUBUNIT: Dimer of alpha and beta chains. A typical microtubule is a
CC       hollow water-filled tube with an outer diameter of 25 nm and an inner
CC       diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to
CC       form protofilaments running lengthwise along the microtubule wall with
CC       the beta-tubulin subunit facing the microtubule plus end conferring a
CC       structural polarity. Microtubules usually have 13 protofilaments but
CC       different protofilament numbers can be found in some organisms and
CC       specialized cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the tubulin family. {ECO:0000305}.
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DR   EMBL; L19616; AAA16925.1; -; Unassigned_DNA.
DR   AlphaFoldDB; Q07972; -.
DR   SMR; Q07972; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; IEA:InterPro.
DR   GO; GO:0007017; P:microtubule-based process; IEA:InterPro.
DR   Gene3D; 1.10.287.600; -; 1.
DR   Gene3D; 3.30.1330.20; -; 1.
DR   Gene3D; 3.40.50.1440; -; 1.
DR   InterPro; IPR002452; Alpha_tubulin.
DR   InterPro; IPR008280; Tub_FtsZ_C.
DR   InterPro; IPR000217; Tubulin.
DR   InterPro; IPR037103; Tubulin/FtsZ-like_C.
DR   InterPro; IPR018316; Tubulin/FtsZ_2-layer-sand-dom.
DR   InterPro; IPR036525; Tubulin/FtsZ_GTPase_sf.
DR   InterPro; IPR023123; Tubulin_C.
DR   PANTHER; PTHR11588; PTHR11588; 1.
DR   Pfam; PF03953; Tubulin_C; 1.
DR   PRINTS; PR01162; ALPHATUBULIN.
DR   SMART; SM00865; Tubulin_C; 1.
DR   SUPFAM; SSF52490; SSF52490; 1.
DR   SUPFAM; SSF55307; SSF55307; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Cytoskeleton; GTP-binding; Microtubule; Nucleotide-binding.
FT   CHAIN           <1..>212
FT                   /note="Tubulin alpha chain"
FT                   /id="PRO_0000048220"
FT   NON_TER         1
FT   NON_TER         212
SQ   SEQUENCE   212 AA;  23835 MW;  5A9A8534E6B94AEA CRC64;
     VDNEAIYDIC RRNLGIERPG YTNLNRLIAH VVSSITASLR FDGSLNVDLN EFQTNLVPYP
     RIHFPLVTYA PVISAAKAVH EANSVSEITN ACFEPNNQMV KCDPRNGKYM ATCLLYRGDV
     VTKDVNAAVA AVRTKRTIQF VDWCPTGFKL GVCYQPPQHV PHGDLAKVDR AVCMLSNTTS
     IAEAWPRLDH KFDLMYSKRA FVHWYVGEGM EE