TBATA_HUMAN
ID TBATA_HUMAN Reviewed; 351 AA.
AC Q96M53; A4QPA8; B2RPQ2; Q5T4G2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Protein TBATA;
DE AltName: Full=Protein SPATIAL;
DE AltName: Full=Stromal protein associated with thymii and lymph node homolog;
DE AltName: Full=Thymus, brain and testes-associated protein;
GN Name=TBATA; Synonyms=C10orf27, SPATIAL;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-237.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLN-237.
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP GLN-237.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role in spermatid differentiation. Modulates
CC thymic stromal cell proliferation and thymus function. {ECO:0000250}.
CC -!- INTERACTION:
CC Q96M53; Q8WWB5: PIH1D2; NbExp=3; IntAct=EBI-24203456, EBI-10232538;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96M53-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96M53-2; Sequence=VSP_035483, VSP_035484;
CC -!- SIMILARITY: Belongs to the TBATA family. {ECO:0000305}.
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DR EMBL; AK057382; BAB71459.1; -; mRNA.
DR EMBL; AL358817; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471083; EAW54411.1; -; Genomic_DNA.
DR EMBL; BC137543; AAI37544.1; -; mRNA.
DR EMBL; BC137544; AAI37545.1; -; mRNA.
DR EMBL; BC139728; AAI39729.1; -; mRNA.
DR CCDS; CCDS7308.1; -. [Q96M53-1]
DR RefSeq; NP_001305171.1; NM_001318242.1. [Q96M53-1]
DR RefSeq; NP_689923.3; NM_152710.3. [Q96M53-1]
DR AlphaFoldDB; Q96M53; -.
DR BioGRID; 128577; 1.
DR IntAct; Q96M53; 1.
DR STRING; 9606.ENSP00000299290; -.
DR iPTMnet; Q96M53; -.
DR PhosphoSitePlus; Q96M53; -.
DR BioMuta; TBATA; -.
DR DMDM; 317373509; -.
DR MassIVE; Q96M53; -.
DR PaxDb; Q96M53; -.
DR PeptideAtlas; Q96M53; -.
DR PRIDE; Q96M53; -.
DR ProteomicsDB; 77295; -. [Q96M53-1]
DR ProteomicsDB; 77296; -. [Q96M53-2]
DR Antibodypedia; 55853; 113 antibodies from 17 providers.
DR DNASU; 219793; -.
DR Ensembl; ENST00000299290.5; ENSP00000299290.1; ENSG00000166220.14. [Q96M53-1]
DR Ensembl; ENST00000692183.1; ENSP00000509602.1; ENSG00000166220.14. [Q96M53-1]
DR Ensembl; ENST00000692747.1; ENSP00000508807.1; ENSG00000166220.14. [Q96M53-2]
DR GeneID; 219793; -.
DR KEGG; hsa:219793; -.
DR UCSC; uc001jrj.1; human. [Q96M53-1]
DR CTD; 219793; -.
DR DisGeNET; 219793; -.
DR GeneCards; TBATA; -.
DR HGNC; HGNC:23511; TBATA.
DR HPA; ENSG00000166220; Tissue enriched (lymphoid).
DR MIM; 612640; gene.
DR neXtProt; NX_Q96M53; -.
DR OpenTargets; ENSG00000166220; -.
DR PharmGKB; PA134924486; -.
DR VEuPathDB; HostDB:ENSG00000166220; -.
DR eggNOG; ENOG502RZQH; Eukaryota.
DR GeneTree; ENSGT00510000048896; -.
DR HOGENOM; CLU_063592_1_0_1; -.
DR InParanoid; Q96M53; -.
DR OMA; VGDPQSN; -.
DR OrthoDB; 1266640at2759; -.
DR PhylomeDB; Q96M53; -.
DR TreeFam; TF333401; -.
DR PathwayCommons; Q96M53; -.
DR SignaLink; Q96M53; -.
DR BioGRID-ORCS; 219793; 16 hits in 1063 CRISPR screens.
DR GenomeRNAi; 219793; -.
DR Pharos; Q96M53; Tbio.
DR PRO; PR:Q96M53; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q96M53; protein.
DR Bgee; ENSG00000166220; Expressed in right testis and 68 other tissues.
DR ExpressionAtlas; Q96M53; baseline and differential.
DR Genevisible; Q96M53; HS.
DR GO; GO:0036064; C:ciliary basal body; IDA:GO_Central.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR InterPro; IPR037394; TBATA-like.
DR PANTHER; PTHR33772; PTHR33772; 1.
DR Pfam; PF15256; SPATIAL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..351
FT /note="Protein TBATA"
FT /id="PRO_0000089786"
FT REGION 16..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 167..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 195..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 292..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..216
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 231..250
FT /note="VLELLCRILETDLLSAIQFW -> KKTSLWDSCRQQWLSSFPSP (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035483"
FT VAR_SEQ 251..351
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035484"
FT VARIANT 237
FT /note="R -> Q (in dbSNP:rs2254174)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15164054, ECO:0000269|PubMed:15489334"
FT /id="VAR_022998"
FT CONFLICT 9
FT /note="D -> G (in Ref. 1; BAB71459)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 351 AA; 39460 MW; BF0368B1FCA9179E CRC64;
MATDVQLADY PLMSPKAELK LEKKSGRKPR SPRDSGPQKE LVIPGIVDFE RIRRALRTPK
PQTPGTYCFG RLSHHSFFSR HHPHPQHVTH IQDLTGKPVC VVRDFPAPLP ESTVFSGCQM
GIPTISVPIG DPQSNRNPQL SSEAWKKELK ELASRVAFLT KEDELKKKEK EQKEEPLREQ
GAKYSAETGR LIPASTRAVG RRRSHQGQQS QSSSRHEGVQ AFLLQDQELL VLELLCRILE
TDLLSAIQFW LLYAPPKEKD LALGLLQTAV AQLLPQPLVS IPTEKLLSQL PEVHEPPQEK
QEPPCSQSPK KTKISPFTKS EKPEYIGEAQ VLQMHSSQNT EKKTSKPRAE S
