TBATA_MOUSE
ID TBATA_MOUSE Reviewed; 393 AA.
AC Q7TSD4; B2ZA64; Q6XBG6; Q6XBG7; Q6XBG8; Q7TSD5; Q8BYU0; Q9EQE4; Q9EQE5;
DT 23-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Protein TBATA;
DE AltName: Full=Protein SPATIAL;
DE AltName: Full=Stromal protein associated with thymii and lymph node {ECO:0000303|PubMed:11196687};
DE AltName: Full=Thymus, brain and testes-associated protein;
GN Name=Tbata; Synonyms=Spatial;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAG37103.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7), SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:ACD01420.1};
RC TISSUE=Thymus {ECO:0000312|EMBL:ACD01420.1};
RX PubMed=11196687; DOI=10.1038/sj.gene.6363695;
RA Flomerfelt F.A., Kim M.G., Schwartz R.H.;
RT "Spatial, a gene expressed in thymic stromal cells, depends on three-
RT dimensional thymus organization for its expression.";
RL Genes Immun. 1:391-401(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAP50908.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), TISSUE SPECIFICITY, AND
RP DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP50908.1};
RC TISSUE=Testis {ECO:0000312|EMBL:AAP50908.1};
RX PubMed=12711538; DOI=10.1016/s1567-133x(03)00024-3;
RA Irla M., Puthier D., Le Goffic R., Victorero G., Freeman T., Naquet P.,
RA Samson M., Nguyen C.;
RT "Spatial, a new nuclear factor tightly regulated during mouse
RT spermatogenesis.";
RL Gene Expr. Patterns 3:135-138(2003).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAP41210.2}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), PARTIAL NUCLEOTIDE SEQUENCE [MRNA]
RP (ISOFORMS 4 AND 5), AND ALTERNATIVE SPLICING.
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAP41210.2};
RC TISSUE=Fetal thymus {ECO:0000312|EMBL:AAP41212.1}, and
RC Thymus {ECO:0000312|EMBL:AAP41210.2};
RX PubMed=15236666; DOI=10.1186/1471-2164-5-41;
RA Irla M., Puthier D., Granjeaud S., Saade M., Victorero G., Mattei M.-G.,
RA Nguyen C.;
RT "Genomic organization and the tissue distribution of alternatively spliced
RT isoforms of the mouse Spatial gene.";
RL BMC Genomics 5:41-41(2004).
RN [4] {ECO:0000305, ECO:0000312|EMBL:ACD01420.1}
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:ACD01420.1};
RC TISSUE=Thymus {ECO:0000312|EMBL:ACD01420.1};
RA Flomerfelt F.A., Alleman M.K., League S.C., Gress R.E.;
RL Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000305, ECO:0000312|EMBL:BAC29958.1}
RP PARTIAL NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7).
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC29958.1};
RC TISSUE=Thymus {ECO:0000312|EMBL:BAC29958.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [6] {ECO:0000305}
RP FUNCTION, INTERACTION WITH KIF17, SUBCELLULAR LOCATION, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=17196196; DOI=10.1016/j.yexcr.2006.11.011;
RA Saade M., Irla M., Govin J., Victorero G., Samson M., Nguyen C.;
RT "Dynamic distribution of Spatial during mouse spermatogenesis and its
RT interaction with the kinesin KIF17b.";
RL Exp. Cell Res. 313:614-626(2007).
RN [7]
RP DEVELOPMENTAL STAGE, AND INTERACTION WITH KIF17.
RX PubMed=17961552; DOI=10.1016/j.yexcr.2007.09.006;
RA Irla M., Saade M., Fernandez C., Chasson L., Victorero G., Dahmane N.,
RA Chazal G., Nguyen C.;
RT "Neuronal distribution of spatial in the developing cerebellum and
RT hippocampus and its somatodendritic association with the kinesin motor
RT KIF17.";
RL Exp. Cell Res. 313:4107-4119(2007).
RN [8]
RP FUNCTION, AND INTERACTION WITH UBA3.
RX PubMed=20937703; DOI=10.1084/jem.20092759;
RA Flomerfelt F.A., El Kassar N., Gurunathan C., Chua K.S., League S.C.,
RA Schmitz S., Gershon T.R., Kapoor V., Yan X.Y., Schwartz R.H., Gress R.E.;
RT "Tbata modulates thymic stromal cell proliferation and thymus function.";
RL J. Exp. Med. 207:2521-2532(2010).
CC -!- FUNCTION: Isoform 1 and isoform 2 may play a role in spermatid
CC differentiation. Isoform 1 and isoform 2 regulate thymus function by
CC modulating stromal cell proliferation via interference with the NEDD8
CC pathway. {ECO:0000269|PubMed:17196196, ECO:0000269|PubMed:20937703}.
CC -!- SUBUNIT: Interacts with KIF17. Interacts with UBA3.
CC {ECO:0000269|PubMed:17196196, ECO:0000269|PubMed:17961552,
CC ECO:0000269|PubMed:20937703}.
CC -!- SUBCELLULAR LOCATION: [Isoform 1]: Cytoplasm, cytosol
CC {ECO:0000269|PubMed:17196196}. Note=Located throughout the cytosol of
CC early round spermatids. By the end stages of round spermatid
CC development, concentrated at the side of the cell near the nascent
CC flagellum and in the manchette. In mature sperm, located in the
CC principle piece of the tail. {ECO:0000269|PubMed:17196196}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytosol
CC {ECO:0000269|PubMed:17196196}. Note=Located throughout the cytosol of
CC early round spermatids. By the end stages of round spermatid
CC development, concentrated at the side of the cell near the nascent
CC flagellum and in the manchette. In mature sperm, located in the
CC principle piece of the tail. {ECO:0000269|PubMed:17196196}.
CC -!- SUBCELLULAR LOCATION: [Isoform 6]: Nucleus
CC {ECO:0000269|PubMed:11196687}.
CC -!- SUBCELLULAR LOCATION: [Isoform 7]: Nucleus
CC {ECO:0000269|PubMed:11196687}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=8;
CC Name=1 {ECO:0000269|PubMed:12711538}; Synonyms=Epsilon
CC {ECO:0000269|PubMed:12711538};
CC IsoId=Q7TSD4-1; Sequence=Displayed;
CC Name=2 {ECO:0000269|PubMed:12711538}; Synonyms=Delta
CC {ECO:0000269|PubMed:12711538};
CC IsoId=Q7TSD4-2; Sequence=VSP_052937;
CC Name=3 {ECO:0000269|PubMed:15236666}; Synonyms=Beta
CC {ECO:0000269|PubMed:15236666};
CC IsoId=Q7TSD4-3; Sequence=VSP_052935, VSP_052937, VSP_052940,
CC VSP_052941, VSP_052942;
CC Name=4 {ECO:0000269|PubMed:15236666}; Synonyms=Alpha
CC {ECO:0000269|PubMed:15236666};
CC IsoId=Q7TSD4-4; Sequence=VSP_052935, VSP_052939, VSP_052941,
CC VSP_052942;
CC Name=5 {ECO:0000269|PubMed:15236666}; Synonyms=Gamma
CC {ECO:0000269|PubMed:15236666};
CC IsoId=Q7TSD4-5; Sequence=VSP_052937, VSP_052941, VSP_052942;
CC Name=6 {ECO:0000269|PubMed:11196687};
CC IsoId=Q7TSD4-6; Sequence=VSP_052935, VSP_052941, VSP_052942;
CC Name=7 {ECO:0000269|PubMed:11196687};
CC IsoId=Q7TSD4-7; Sequence=VSP_052935, VSP_052937, VSP_052941,
CC VSP_052942;
CC Name=8; Synonyms=Zeta;
CC IsoId=Q7TSD4-8; Sequence=VSP_052935, VSP_052936, VSP_052938;
CC -!- TISSUE SPECIFICITY: Expressed in the subcapsular region of the thymus
CC and lymph node (at protein level). Highly expressed in thymic cortical
CC stromal cells and testis. Lower levels found in brain cortex,
CC hippocampus, kidney, cerebellum, skeletal muscle, epididymis and ovary.
CC No expression detected in other lymphoid organs including bone marrow
CC and spleen. Isoform 1 and isoform 2 are expressed predominantly in
CC testis. Isoform 3, isoform 4 and isoform 5 are expressed predominantly
CC in thymus although isoform 3 is also expressed in testis. In the CNS,
CC highly expressed in restricted areas, the cerebellum and hippocampus.
CC {ECO:0000269|PubMed:12711538}.
CC -!- DEVELOPMENTAL STAGE: In testis, isoform 1 and isoform 2 are expressed
CC only in the adult from postnatal week 7. Expression is detected in
CC pachytene spermatocytes, increases greatly in round spermatids and is
CC very strong in round/elongating and elongating spermatids. Expression
CC is reduced in condensed spermatids and persists in spermatozoa. Isoform
CC 3 is specifically expressed in round spermatids and is greatly reduced
CC in spermatids under maturation (at protein level). Isoform 7 is
CC detected in the embryo from day 10 while isoform 7 is not detected
CC until day 12. In brain, predominantly expressed by granule cells during
CC cerebellar development. Isoform 1 and isoform 3 are differentially
CC expressed during cerebellar development. {ECO:0000269|PubMed:11196687,
CC ECO:0000269|PubMed:12711538, ECO:0000269|PubMed:17196196,
CC ECO:0000269|PubMed:17961552}.
CC -!- INDUCTION: Up-regulated in aged mice (4 months of age or older).
CC -!- SIMILARITY: Belongs to the TBATA family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP41211.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAP50907.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAP50908.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF257502; AAG37103.1; -; mRNA.
DR EMBL; AF257503; AAG37104.1; -; mRNA.
DR EMBL; AF521591; AAP50907.1; ALT_INIT; mRNA.
DR EMBL; AF521592; AAP50908.1; ALT_INIT; mRNA.
DR EMBL; AY243457; AAP41210.2; -; mRNA.
DR EMBL; AY243458; AAP41211.1; ALT_FRAME; mRNA.
DR EMBL; AY243459; AAP41212.1; -; mRNA.
DR EMBL; EU622858; ACD01420.1; -; mRNA.
DR EMBL; AK038284; BAC29958.1; -; mRNA.
DR CCDS; CCDS23873.1; -. [Q7TSD4-1]
DR CCDS; CCDS23874.2; -. [Q7TSD4-5]
DR CCDS; CCDS48572.1; -. [Q7TSD4-2]
DR CCDS; CCDS48573.1; -. [Q7TSD4-6]
DR RefSeq; NP_001017407.1; NM_001017407.1. [Q7TSD4-7]
DR RefSeq; NP_001017409.1; NM_001017409.1.
DR RefSeq; NP_001017419.1; NM_001017419.2. [Q7TSD4-2]
DR RefSeq; NP_001017433.1; NM_001017433.2. [Q7TSD4-1]
DR RefSeq; NP_075551.3; NM_023064.3. [Q7TSD4-6]
DR AlphaFoldDB; Q7TSD4; -.
DR BioGRID; 211165; 1.
DR STRING; 10090.ENSMUSP00000036422; -.
DR iPTMnet; Q7TSD4; -.
DR PhosphoSitePlus; Q7TSD4; -.
DR MaxQB; Q7TSD4; -.
DR PaxDb; Q7TSD4; -.
DR PRIDE; Q7TSD4; -.
DR ProteomicsDB; 262938; -. [Q7TSD4-1]
DR ProteomicsDB; 262939; -. [Q7TSD4-2]
DR ProteomicsDB; 262940; -. [Q7TSD4-3]
DR ProteomicsDB; 262941; -. [Q7TSD4-4]
DR ProteomicsDB; 262942; -. [Q7TSD4-5]
DR ProteomicsDB; 262943; -. [Q7TSD4-6]
DR ProteomicsDB; 262944; -. [Q7TSD4-7]
DR ProteomicsDB; 262945; -. [Q7TSD4-8]
DR Antibodypedia; 55853; 113 antibodies from 17 providers.
DR DNASU; 65971; -.
DR Ensembl; ENSMUST00000035894; ENSMUSP00000036422; ENSMUSG00000020096. [Q7TSD4-1]
DR Ensembl; ENSMUST00000121297; ENSMUSP00000113253; ENSMUSG00000020096. [Q7TSD4-5]
DR Ensembl; ENSMUST00000122261; ENSMUSP00000113902; ENSMUSG00000020096. [Q7TSD4-2]
DR GeneID; 65971; -.
DR KEGG; mmu:65971; -.
DR UCSC; uc007ffm.2; mouse. [Q7TSD4-5]
DR UCSC; uc007ffn.2; mouse. [Q7TSD4-1]
DR UCSC; uc007ffo.2; mouse. [Q7TSD4-2]
DR UCSC; uc007ffq.1; mouse. [Q7TSD4-7]
DR UCSC; uc007ffr.2; mouse. [Q7TSD4-6]
DR CTD; 219793; -.
DR MGI; MGI:1923820; Tbata.
DR VEuPathDB; HostDB:ENSMUSG00000020096; -.
DR eggNOG; ENOG502RZQH; Eukaryota.
DR GeneTree; ENSGT00510000048896; -.
DR HOGENOM; CLU_063592_1_0_1; -.
DR InParanoid; Q7TSD4; -.
DR OMA; VGDPQSN; -.
DR OrthoDB; 1266640at2759; -.
DR PhylomeDB; Q7TSD4; -.
DR TreeFam; TF333401; -.
DR BioGRID-ORCS; 65971; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Tbata; mouse.
DR PRO; PR:Q7TSD4; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q7TSD4; protein.
DR Bgee; ENSMUSG00000020096; Expressed in thymus and 71 other tissues.
DR ExpressionAtlas; Q7TSD4; baseline and differential.
DR Genevisible; Q7TSD4; MM.
DR GO; GO:0036064; C:ciliary basal body; ISO:MGI.
DR GO; GO:0005829; C:cytosol; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0048515; P:spermatid differentiation; NAS:UniProtKB.
DR InterPro; IPR037394; TBATA-like.
DR PANTHER; PTHR33772; PTHR33772; 1.
DR Pfam; PF15256; SPATIAL; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Developmental protein; Differentiation;
KW Nucleus; Reference proteome; Spermatogenesis.
FT CHAIN 1..393
FT /note="Protein TBATA"
FT /id="PRO_0000351147"
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 168..188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 202..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 340..393
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..222
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 236..264
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 379..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..14
FT /note="MTTEVNQLSEHPLV -> MFLGNVYKGSLAPRRDEVT (in isoform 3,
FT isoform 4, isoform 6, isoform 7 and isoform 8)"
FT /evidence="ECO:0000303|PubMed:11196687,
FT ECO:0000303|PubMed:15236666, ECO:0000303|Ref.4"
FT /id="VSP_052935"
FT VAR_SEQ 98..166
FT /note="VTGREDLEHSLPLTTSFQLLQAPGVQPMDLTPSADIAGKPVCVVRDEFSLSA
FT LTQPTFLSRCLMGMPTI -> APSSSWGPAHGSHSLCRYRWEACLRGQGRVLSVGLDSA
FT HILIPLSDGDAHHLCPHWGSTVQSEPPAFYF (in isoform 8)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_052936"
FT VAR_SEQ 98..131
FT /note="Missing (in isoform 2, isoform 3, isoform 5 and
FT isoform 7)"
FT /evidence="ECO:0000303|PubMed:11196687,
FT ECO:0000303|PubMed:12711538, ECO:0000303|PubMed:15236666"
FT /id="VSP_052937"
FT VAR_SEQ 167..393
FT /note="Missing (in isoform 8)"
FT /evidence="ECO:0000303|Ref.4"
FT /id="VSP_052938"
FT VAR_SEQ 184
FT /note="S -> SAEDTGRTKQHLPPPTPILPVLS (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15236666"
FT /id="VSP_052939"
FT VAR_SEQ 185
FT /note="D -> DLKTQGGQNNTYRPPPPSFLSSQT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15236666"
FT /id="VSP_052940"
FT VAR_SEQ 212..226
FT /note="QKEEPPLREPPPREQ -> VGVAQRMEPRKKRPS (in isoform 3,
FT isoform 4, isoform 5, isoform 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:11196687,
FT ECO:0000303|PubMed:15236666"
FT /id="VSP_052941"
FT VAR_SEQ 227..393
FT /note="Missing (in isoform 3, isoform 4, isoform 5, isoform
FT 6 and isoform 7)"
FT /evidence="ECO:0000303|PubMed:11196687,
FT ECO:0000303|PubMed:15236666"
FT /id="VSP_052942"
SQ SEQUENCE 393 AA; 43842 MW; ED5BB0126B6A6947 CRC64;
MTTEVNQLSE HPLVSPKAEP QPETKPENLP RSHGDVGLQK ETVVPGIVDF ELIHEELKTT
KPQTSQPTPS AYRFGRLSHH SFFSRHHPQP QRVTHIQVTG REDLEHSLPL TTSFQLLQAP
GVQPMDLTPS ADIAGKPVCV VRDEFSLSAL TQPTFLSRCL MGMPTISVPI GDPQSNRNPQ
LSTSDTWRKK LKDLASRVTV FTKEIQPKPD EQKEEPPLRE PPPREQGAKY SAETGRLIPA
SSQALTRRNR QGQRVHPSSK DGGVQASILQ DQELLILELL CQILQTDSLR AIQFWLLYAP
SKEKDLALGL LQTAVAQLIP QPLSSIPAEK LWNHLQELQE PQETQEAAYS PSLKKTRSPP
LPKTDKPEYI GKAQVLLVHP SEDPEEKTTK AES
